Insulin sensitizing and α-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma

Choi, Soo Bong; Ko, Byoung‐Seob; Park, Seong Kyu; Jang, Jin Sun; Park, Sunmin

doi:10.1016/j.lfs.2005.05.101

Cited by 66 publications

(56 citation statements)

References 29 publications

(39 reference statements)

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“…These anthraquinone derivatives are well known to exhibit a variety of biological activities, such as antibacterial and antifungal [37], antitumor [38], antioxidant [39], cytotoxic and hypoglycaemic activities [40,41]. Other chemicals contained in the plant include saponin, which acts as a laxative and expels intestinal parasites.…”

Section: Resultsmentioning

confidence: 99%

Study of Antioxidant Activity and Immune Stimulating Potency of the Ethnomedicinal Plant, Cassia alata (L.) Roxb

Chatterjee¹,

Chatterjee²,

Dey³

et al. 2012

Med Aromat Plants

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Section: Resultsmentioning

confidence: 99%

Study of Antioxidant Activity and Immune Stimulating Potency of the Ethnomedicinal Plant, Cassia alata (L.) Roxb

Chatterjee¹,

Chatterjee²,

Dey³

et al. 2012

Med Aromat Plants

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“…On the other hand, however, rhaponticin, which is very similar in structure to desoxyrhaponticin, is almost devoid of such inhibitory activities. Interestingly, rhaponticin was also reported not to be capable of inhibiting ␣-glucoamylase activity (Choi et al, 2006). This indicates that a subtle difference in structure between desoxyrhaponticin and rhaponticin (which has an additional hydroxyl group compared with desoxyrhaponticin) is critical for their huge differences in bioactivities.…”

Section: Discussionmentioning

confidence: 99%

“…These include rhaponticim, rhapontigenin, desoxyrhapontigenin, and desoxyrhaponticin. Recent studies have also indicated the possible antidiabetic actions of the extracts and constituents of rhubarb (Babu et al, 2004;Choi et al, 2005Choi et al, , 2006.…”

mentioning

confidence: 99%

Desoxyrhaponticin (3,5-Dihydroxy-4′-methoxystilbene 3-O-β-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies

Li¹,

Tao²,

Lau³

et al. 2006

J Pharmacol Exp Ther

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Rhubarb extracts have been reported to improve oral glucose tolerance in diabetic animals. In the present study we have investigated the antidiabetic actions of desoxyrhaponticin, a major stilbene in rhubarb, as a glucose uptake inhibitor. Desoxyrhaponticin was demonstrated to inhibit glucose uptake in rabbit intestinal membrane vesicles as well as in rat everted gut sleeves, with IC 50 values of 148.3 and 30.9 M, respectively. Kinetics studies revealed that desoxyrhaponticin is a competitive inhibitor of glucose uptake in both systems. Moreover, desoxyrhaponticin could reduce glucose uptake in the intestinal membrane vesicles of both normal and diabetic rats. In addition, glucose uptake in the renal membrane vesicles of both normal and diabetic rats was reduced by desoxyrhaponticin. Under the inhibition of desoxyrhaponticin, uptake of glucose in both the intestinal and renal membrane vesicles of the normal rats was no different from that of the diabetic rats. The IC 50 values of the uptake inhibition in the renal membrane vesicles of normal and diabetic rats were 118.8 and 115.7 M, respectively. In a type 2 diabetic animal model in which rats have been treated with streptozotocin at the neonatal stage, postprandial hyperglycemia was significantly suppressed by oral administration of this compound (300 mg/kg b.wt.). These results suggest that desoxyrhaponticin is an agent that is potentially effective in controlling postprandial hyperglycemia in diabetes. The in vivo antidiabetic action of this compound can be explained, in part at least, by inhibition of glucose transport in the small intestine and inhibition of glucose reabsorption in the kidney.

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“…Ten to twelve days after the initiation of differentiation, the insulin-stimulated glucose uptake was analyzed by measuring the uptake of 2-deoxy-D- [ 3 H] glucose in 3T3-L1 adipocytes. 17) Briefly, the adipocytes in 12-well plates were pre-incubated at 37 C for 8 h with lowglucose Dulbecco's modified Eagle's medium (DMEM; Invitrogen, Carlsbad, CA, USA) containing 2 or 20 mM ginsenosides. At the end of the incubation period, the medium was replaced by a Krebs-Ringer-Hepes buffer containing the respective drugs and 0.2 or 10 nm insulin and left at 37 C for 10 min.…”

Section: Methodsmentioning

confidence: 99%

Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 CellsviaPKA-Dependent Pathways

Park

Ahn

Kwon

et al. 2008

Bioscience, Biotechnology, and Biochemistry

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Insulin sensitizing and α-glucoamylase inhibitory action of sennosides, rheins and rhaponticin in Rhei Rhizoma

Cited by 66 publications

References 29 publications

Study of Antioxidant Activity and Immune Stimulating Potency of the Ethnomedicinal Plant, Cassia alata (L.) Roxb

Study of Antioxidant Activity and Immune Stimulating Potency of the Ethnomedicinal Plant, Cassia alata (L.) Roxb

Desoxyrhaponticin (3,5-Dihydroxy-4′-methoxystilbene 3-O-β-d-glucoside) Inhibits Glucose Uptake in the Intestine and Kidney: In Vitro and in Vivo Studies

Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 CellsviaPKA-Dependent Pathways

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