Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 Cells<i>via</i>PKA-Dependent Pathways

Park, Sunmin; Ahn, Il Sung; Kwon, Dae Young; Ko, Byoung‐Seob; Jun, Won Kyung

doi:10.1271/bbb.80205

Cited by 87 publications

(81 citation statements)

References 33 publications

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“…Some studies have reported that ginseng increases the PPARc mRNA expression in adipose tissue (Park et al 2005;Mollah et al 2009) and in some studies, it decreases. For instance, ginsenoside Rb1, Rg1, Rg3 and Rh2 decreased the lipid accumulation and PPARc mRNA expression levels in 3T3-L1 adipocytes (Hwang et al 2007;Park et al 2008;Hwang et al 2009), and ginsenoside Rh2 and Rg3 have been reported as an antagonist for PPARc (Hwang et al 2007;Hwang et al 2009). In our study, expression levels of mRNA and protein expression both of PPARc2 and SREBP-1 levels were decreased in WAT of KGE fed mice.…”

Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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The present study examined the antiobesity effect and mechanism of action of Korean white ginseng extracts (KGE) using high-fat diet (HFD)-induced obese mice. Mice were fed a low-fat diet (LFD), HFD or HFD containing 0.8 and 1.6% (w/ w) KGE diet (HFD ? 0.8KGE and HFD ? 1.6KGE) for 8 weeks. We also examined the effects of KGE on plasma triglyceride (TG) elevation in mice administrated with oral lipid emulsion. Body weight gain and white adipose tissue (WAT) weight were significantly decreased in the HFD ? 1.6KGE group, compared with the HFD group. The plasma TG levels were also significantly reduced in both HFD ? 0.8KGE and HFD ? 1.6KGE groups, while leptin levels were significantly decreased in only the HFD ? 1.6KGE group, compared with the HFD group. The HFD ? 1.6KGE group showed significantly lower mRNA levels of lipogenesis-related genes, including peroxisome proliferator-activated receptorc2 (PPARc2), sterol regulatory element binding protein-1c (SREBP-1c), lipoprotein lipase (LPL), fatty acid synthase (FAS) and diacylglycerol acyltransferase 1 (DGAT1), compared with the HFD group. In addition, a dose of 1000 mg/kg KGE inhibited the elevation of plasma TG levels compared with mice given the lipid emulsion alone. These results suggest that the anti-obesity effects of KGE may be elicited by regulating expression of lipogenesis-related genes in WAT and by delaying intestinal fat absorption.

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Section: Discussionmentioning

confidence: 99%

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

et al. 2010

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“…We performed HPLC (Shimadzu Corp., Kyoto, Japan) analysis and confi rmed that the Rb1 had a purity of у 98% using an Rb1 standard obtained from LKT Laboratories (St. Paul, MN). Radiochemical [9, H(N9)]palmitic acid and L -[ 3 H]carnitine were purchased from PerkinElmer (Boston, MA). HBSS, Williams' E medium, and HepatoZYME-SFM medium were obtained from Life Technologies (Carlsbad, CA).…”

Section: Methodsmentioning

confidence: 99%

Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

Shen

Xiong

Wang

et al. 2013

Journal of Lipid Research

113

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“…A number of active components of P. ginseng have been isolated and characterized, and Rg1 is regarded as the main compound responsible for many pharmaceutical actions of ginseng [9]. Several in vitro studies have demonstrated that Rg1 has anti-diabetic activity [10][11][12]. Recently, accumulating data have suggested that Rg1 also has the ability to promote neovascularization into a polymer scaffold in vivo and the proliferation, chemoinvasion, and tubulogenesis of human umbilical vein endothelial cells (HUVECs) in vitro [13,14].…”

Section: Introductionmentioning

confidence: 99%

Beneficial effects of ginsenoside-Rg1 on ischemia-induced angiogenesis in diabetic mice

Yang¹,

Chen²,

Tao³

et al. 2012

ABBS

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Neovascularization and the formation of collateral vessels are often impaired in diabetes mellitus (DM) population compared with non-diabetics. Alterations in vascular endothelial growth factor (VEGF) signaling and endothelial nitric oxide synthase (eNOS) dysfunction have been confirmed to play a crucial role in impaired neovascularization in diabetic mice. Accumulating data have suggested that Rg1, a main component of Panax ginseng, has the ability to promote tubulogenesis of human umbilical vein endothelial cells (HUVECs) in vitro, and that the mechanism involves increased expression level of VEGF as well as increased eNOS activation. Thus, we speculated that Rg1 might also have therapeutic effects on the impairment of neovascularization in diabetic individuals. The aim of the present study was to investigate whether Rg1 could improve angiogenesis in ischemic hindlimb of diabetic mice in vivo. Our data demonstrated that Rg1 treatment resulted in improved angiogenesis in the diabetic ischemic hindlimb, and the potential mechanism might involve increased eNOS activation, upregulated VEGF expression, and inhibited apoptosis. Our results suggest that Rg1 may be used as a novel and useful adjunctive drug for the therapy of peripheral arterial disease in DM.

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Ginsenosides Rb1 and Rg1 Suppress Triglyceride Accumulation in 3T3-L1 Adipocytes and Enhance β-Cell Insulin Secretion and Viability in Min6 CellsviaPKA-Dependent Pathways

Cited by 87 publications

References 33 publications

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats

Beneficial effects of ginsenoside-Rg1 on ischemia-induced angiogenesis in diabetic mice

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