Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Lee, Young-Sil; Cha, Byung‐Yoon; Yamaguchi, Kohji; Choi, Sooyoung; Yonezawa, Takayuki; Teruya, Toshiaki; Nagai, Kazuo; Woo, Je‐Tae

doi:10.1007/s10616-010-9288-7

Cited by 46 publications

(44 citation statements)

References 46 publications

(55 reference statements)

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“…These extracts are known to improve blood flow, relieve fatigue, and attenuate oxidative stress in the body [8917]. Furthermore, Lee et al [18] reported that Korean white ginseng extracts regulated lipogenesis-related gene expressions in white adipose tissues, inhibited intestinal fat absorption, and reduced body weight.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

et al. 2016

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This study was performed to investigate the antioxidant and hepatoprotective effects of fermented red ginseng (Panax ginseng C.A. Meyer; FRG) on high-fat diet-induced hyperlipidemia in rats. Sprague-Dawley rats were divided into four groups of seven: normal control, NC; high-fat diet control, HFC; high-fat diet–0.5% FRG, HF-FRGL; and high-fat diet–1% FRG, HF-FRGH. All rats were fed a high-fat diet for eight weeks, except those in the NC group, while rats in the FRG treatment groups received drinking water containing 0.5% or 1% FRG. After eight weeks of treatment, levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), and high-density lipoprotein-cholesterol (HDL-C) in the serum were measured. The concentration of the oxidative stress marker malondialdehyde (MDA), and activity of antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in rat liver were evaluated. Histological analysis of the liver was performed using hematoxylin and eosin. The high-fat diet markedly increased serum levels of ALT, AST, TC, TG, and LDL-C and hepatic MDA levels, while administration of FRG to the hyperlipidemic rats resulted in a significant decline in the levels of these parameters. Furthermore, the decline in the levels of serum HDL-C and hepatic SOD, CAT, and GSH-Px induced by the high-fat diet was attenuated by FRG treatment. In addition, histopathological analysis of liver sections suggested that FRG treatment also provided protection against liver damage. These results suggested that FRG improved lipid profiles, inhibited lipid peroxidation, and played a protective role against liver injury in hyperlipidemic rats.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

et al. 2016

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“…Our evidence suggests that the 20% RMR-LM extract may decrease lipogenesis partly by regulating PPARγ signaling. SREBP-1 is a major transcription factor involved in the activation of lipogenic genes such as FAS and ACC (22,23). As the hepatic SREBP-1 mRNA level was significantly lower in the 10% RMR-LM group and 20% RMR-LM group than in the control group, this lower SREBP-1 level could have contributed to the reduction in the FAS and ACC mRNA levels in the liver.…”

Section: Discussionmentioning

confidence: 99%

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Choi

Ryu

Park

et al. 2017

Experimental and Therapeutic Medicine

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Abstract. Robusta beans cultivated with Monascus ruber (RMR) were successively fermented with Leuconostoc mesenteroides (LM) and the antiobesity effects were examined. To produce an obese mouse model to investigate the hypolipidemic effects, ICR mice were fed the same high-fat diet for 6 weeks. Treatment groups were given 10 or 20% RMR-LM. Body weight changes in the 20% RMR-LM group were lower compared with those in the control group. Visceral adipose tissue weight and adipose size were significantly lower in the 20% RMR-LM group compared with those in the control group. Significant improvement in glucose tolerance was observed in the 10 and 20% RMR-LM groups compared with the control group. The 20% RMR-LM group exhibited a significant reduction in serum glucose concentration. Hepatic mRNA levels of sterol regulatory element-binding protein 1, fas cell surface death receptor, and peroxisome proliferator-activated receptor γ, which are associated with lipid, and fatty acid metabolism, in the 20% RMR-LM group were significantly lower compared with those in the control group. The results of the present study demonstrated that 20% RMR-LM may be used to prevent obesity, and ameliorate diabetes and lipid metabolism imbalances.

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“…24) Korean white ginseng extracts showed a decrease of FAS expression in white adipose tissue of high-fat diet-induced obese mice. 25) Korean ginseng powder affected a lowering of the serum total cholesterol level by inhibiting HMG-CoA reductase activity in avian liver. 26) Lee et al reported that KRG improved insulin sensitivity with AMPK activation in OLETF rats.…”

Section: )mentioning

confidence: 99%

Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

Lee

Kim

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Korean Ginseng, the root Panax ginseng CA Meyer, has been widely used as a traditional herbal medicine in East Asian countries. In this study, we investigated the effects of Korean Red Ginseng water extract (KRGE) on hepatic lipid accumulation in HepG2 cells. First, we investigated the cytotoxic effects of KRGE on HepG2 cells. Cytotoxicity was unaffected in the concentrations of 1–50 μg/ml of KRGE.Intracellular lipid accumulation was assessed by the quantification of intracellular triglyceride and cholesterol contents. KRGE decreased hepatic triglyceride and cholesterol levels. Moreover, KRGE suppressed expression of fatty acid synthase (FAS) and 3‐hydroxy‐3‐methyl glutaryl coenzyme A (HMG‐CoA) reductase, a rate‐limiting enzyme in hepatic cholesterol synthesis. These results suggest that KRGE may reduce hepatic lipid accumulation by inhibition of FAS and HMG‐CoA reductase expression in HepG2 cells. Consequently, KRGE may be beneficial as a functional food ingredient to improve various hepatic diseases by reducing hepatic lipid accumulation.

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Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice

Cited by 46 publications

References 46 publications

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

Antioxidant and hepatoprotective effects of fermented red ginseng against high fat diet-induced hyperlipidemia in rats

Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Effects of Korean Red Ginseng extract on hepatic lipid accumulation in HepG2 cells

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