Anti-obesity effect of robusta fermented with Leuconostoc mesenteroides in high-fat diet-induced obese mice

Abstract

Abstract. Robusta beans cultivated with Monascus ruber (RMR) were successively fermented with Leuconostoc mesenteroides (LM) and the antiobesity effects were examined. To produce an obese mouse model to investigate the hypolipidemic effects, ICR mice were fed the same high-fat diet for 6 weeks. Treatment groups were given 10 or 20% RMR-LM. Body weight changes in the 20% RMR-LM group were lower compared with those in the control group. Visceral adipose tissue weight and adipose size were significantly lower in the 20% RMR-LM group compared with those in the control group. Significant improvement in glucose tolerance was observed in the 10 and 20% RMR-LM groups compared with the control group. The 20% RMR-LM group exhibited a significant reduction in serum glucose concentration. Hepatic mRNA levels of sterol regulatory element-binding protein 1, fas cell surface death receptor, and peroxisome proliferator-activated receptor γ, which are associated with lipid, and fatty acid metabolism, in the 20% RMR-LM group were significantly lower compared with those in the control group. The results of the present study demonstrated that 20% RMR-LM may be used to prevent obesity, and ameliorate diabetes and lipid metabolism imbalances.

Leuconostoc Citreum Inhibits Adipogenesis and Lipogenesis by Inhibiting p38 MAPK/Erk 44/42 and Stimulating AMPKα Signaling Pathways

“…Furthermore, Soypro treatment reduced low density lipoprotein cholesterol (LDL) levels without affecting body weight in obese rats [ 25 ]. Another study reported that pear extract and robusta fermented with L. mesenteroids significantly reduced body weight and adipose tissue mass, and the size of lipids in liver in obese rats compared to control rats [ 27 , 33 ]. Supplementation with L. mesenteroids reduced blood urea nitrogen, glucose, and triglyceride levels in obese mice serum, as well as fatty liver development and liver steatosis in comparison with controls [ 26 , 34 ].…”

Multilocus Sequence Typing of Leuconostoc mesenteroides Strains From the Qinghai-Tibet Plateau

“…Some studies have shown that L. mesenteroides plays significant roles in fermentation of foods, such as sauerkraut from Europe and kimchi from East Asia ( Beganovic et al, 2011 ), and it contributes to the improvement of the nutritional and organoleptic properties of fermented foods. In addition, L. mesenteroides is also widely used in the field of in the biochemical and pharmaceutical industries ( Choi et al, 2017 ). The demand for producing high quality dextran and their derivatives continues increasing all over the world ( Naessens et al, 2005 ).…”