Insulin Sensitivity of the Human Brain

Butterfield, W. J. H.; Sells, R. A.; Abrams, M. E.; Sterky, G; Whichelow, M. J.

doi:10.1016/s0140-6736(66)90757-4

Cited by 49 publications

(12 citation statements)

References 9 publications

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“…Butterfield et al and Butterfield, AbT Sterky, and Whichelow (8,9,13) arrived at the conclusion that arterial blood sugar must exceed a certain threshold value before glucose will enter the muscle cells, and that the effect of insulin is to lower this threshold, whereas insulin apparently does not alter the relationship between rise of blood glucose and increase in glucose uptake.…”

Section: Discussionmentioning

confidence: 99%

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

Christensen¹,

Ørskov²

1968

J. Clin. Invest.

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Section: Discussionmentioning

confidence: 99%

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

Christensen¹,

Ørskov²

1968

J. Clin. Invest.

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“…However, a slow entry of insulin into the cerebrospinal fluid has been demonstrated (72), and an effect of intracisternally administered insulin on glycogen synthesis has been observed (70,73). An effect of the hormone on glucose uptake by the human brain in vivo has also been reported (74) and some newer studies with brain slices also indicate an effect of insulin on glycogen synthesis (75); some of these data suggest an effect on sugar transport. No effect of the hormone was observed in synaptosomes (62).…”

Section: Brainmentioning

confidence: 99%

Membrane Transport: Its Relation to Cellular Metabolic Rates

Elbrink¹,

Bihler²

1975

Science

252

101

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“…For all the groups, no obvious correlation appeared between the presence or the absence of clinical signs and the degree or severity of hypoglycemia. This implicates the concept of an individual sensitivity to hypoglycemia which could correspond to individual variations in the cerebral threshold for utilization of glucose, 18 or to individual variations in the counterregulatory mechanisms evoked by hypoglycemia.…”

Section: Discussionmentioning

confidence: 79%

Plasma Insulin in Reactive Hypoglycemia

Luyckx

Lefèbvre

1971

Diabetes

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Among 663 standard four-hour oral glucose tolerance tests (OGTT) performed in a Department of Internal Medicine, forty-seven curves demonstrated reactive hypoglycemia of 45 mg. per 100 ml. or less at one or more occasions. Subsequent analysis of the records of the corresponding patients allows their partition into the following groups: IA. Obesity (11), IB. Obesity with chemical diabetes (9), II. Postgastrectomy syndrome (3), III. Chemical diabetes without obesity (1), IV. Renal glycosuria (7), V. Isolated reactive hypoglycemia (16).In order to determine the role of plasma insulin in the pathogenesis of the syndrome, the insulin response of each group of subjects presenting reactive hypoglycemia was compared to that of a control group of similar age, sex and weight with similar pathological findings but without reactive hypoglycemia. The results indicate that plasma insulin values can not account for the reactive hypoglycemia in the groups IA, IB, III and IV, and thus other factors may be responsible for the occurrence of hypoglycemia in most cases of this syndrome.In contrast, an exaggerated insulin response exists in group II, and in seven out of the sixteen cases of isolated reactive hypoglycemia.No correlation was found between the presence of clinical symptoms evoking reactive hypoglycemia during the usual life and the severity of the hypoglycemia recorded during the OGTT. DIABETES 20:435-42, June, 1971.Hypoglycemia following a meal is a relatively frequent condition first described by Harris. 1 Its pathogenesis remains far from being elucidated. 2 -3 It is usually associated with abnormalities such as obesity, chemical diabetes, gastrectomy or accelerated gastric emptying. 4 ' 7 The present study has been undertaken in order to investigate the role of insulin in the pathogenesis of the syndrome. In contrast to other similar studies, the major criterion used was the existence of a true biological hypoglycemia with or without clinical signs of neuroglucopenia. Furthermore, the plasma insulin response to

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Insulin Sensitivity of the Human Brain

Cited by 49 publications

References 9 publications

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

The relationship between endogenous serum insulin concentration and glucose uptake in the forearm muscles of nondiabetics

Membrane Transport: Its Relation to Cellular Metabolic Rates

Plasma Insulin in Reactive Hypoglycemia

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