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Insulin fixation and glucose uptake have been studied in the forearm tissues of nine lean non-diabetic men for three consecutive hours, during a fasting state, an intra-arterial infusion of a small dose of insulin (25-100 mU) and a recovery period. When insulin was administered, the arterial plasma immune-reactive insulin rose to levels ranging from 15 to 65 ~U/ml; the tissue insulin fixation was significantly increased during this period, but no effect on tissue glucose uptake was observed. A close correlation was found between the arterial plasma insulin concentration and the tissue insulin fixation.-The injection of 200 nag glucose intraarterially at the end of the study resulted in a reversal of the arterio-venous gradient of plasma insulin concentration.-The results show that large amounts of circulating insulin can be bound to the forearm tissues without exerting an effect on glucose uptake. It is suggested that the binding of insulin occurs at the vascular endothelium and that it is reversible by increased concentrations of blood glucose. die Glucoseaufnahme ausiiben. Man muB annehmen, dab die Insulinbindung am Gef/~Bendothel erfolgt und de2 sic durch steigende Konzentration der Blutglucose reversibel ist.

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