Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

Oliveira, Ana Cláudia de; Parise, Edison Roberto; Catarino, Regina Maria; Lanzoni, Valéria Pereira; Leite-Mor, Mariliza M B; Simon, Karin Argenti; Junqueira, Virgínia

doi:10.3109/10715760903247249

Cited by 15 publications

(7 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Those with higher insulin resistance, as estimated by the HOMA, had a greater GPx activity compared to those with a lower insulin resistance [25]. In patients with chronic hepatitis C, Oliviera et al [26] reported that those with higher insulin resistance, also assessed by the HOMA index, had a greater GPx activity and a lower total blood glutathione concentration compared to those with lower insulin resistance. Furthermore, in our study, the insulin resistance predominantly affected the liver as shown by the HOMA (a fasting index primarily exploring liver insulin resistance) as well as by a liver insulin resistance index (Table 2).…”

Section: Discussionmentioning

confidence: 99%

Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women

Lavoie¹,

Rabasa‐Lhoret²,

Ziai³

et al. 2011

J Diabetes Metab

View full text Add to dashboard Cite

Objective: Oxidative stress plays a role in obesity-related diseases. We hypothesize that abnormalities of the glutathione system are associated with the initial phase leading to development of cardiometabolic abnormalities such as cardiovascular diseases and type 2 diabetes in apparently healthy obese women. By measuring different glutathione parameters, we expect to find a dichotomy that can discriminate between obese women who have such sub-clinical abnormalities. Subjects: This is a cross-sectional analysis in 59 postmenopausal obese women. Total blood glutathione, glutathione peroxidase (GPx) and glutathione reductase activity, blood lipids, apolipoprotein B-100 (apoB), fasting and area under the curve (AUC) for glycemia and insulinemia during an oral glucose tolerance test, insulin sensitivity measurement and indices, serum inflammatory markers and carotid intima-media thickness (CIMT, by magnetic resonance imaging) were measured. Results: Blood GPx activity had a bimodal distribution. Subjects were then divided into two groups according to their GPx activity (cut-off: 2.0 nmol/min/mg protein, P<0.01). Age and BMI were similar between the groups. Women with higher GPx activity had 13% more apoB (P=0.02), 10% higher glycemia AUC (P=0.04), hepatic insulin resistance (28% and 25% higher HOMA and liver insulin resistance index values, P<0.04) and increased CIMT by 8-13% (P=0.013) without evidence of inflammation, changes in blood lipids, and fasting glycemia and insulinemia. Conclusion: Results suggest that a modification in the glutathione system is associated with insulin resistance and increased intima-media thickness, both of which are associated with cardiovascular disease risk. Blood GPx activity may be a parameter contributing in the identification of sub-clinical but clinically relevant asymptomatic cardiometabolic abnormalities in obese women. J ou rna l o f D ia be tes & M e ta bolism

show abstract

Section: Discussionmentioning

confidence: 99%

Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women

Lavoie¹,

Rabasa‐Lhoret²,

Ziai³

et al. 2011

J Diabetes Metab

View full text Add to dashboard Cite

show abstract

“…The study by Oliveira et al . carried out in 52 genotype non-3 infected CHC patients found oxidative stress to be related to IR but not steatosis [97]. In contrast, in the Vidali et al .’s study oxidative stress which was observed in 61% out of 107 genotype non-3 CHC patients, was associated with steatosis, but not with IR.…”

Section: Molecular Mechanisms Of Hcv-induced Insulin Resistancementioning

confidence: 98%

Review article Insulin resistance and its consequences in chronic hepatitis C

Kukla¹,

Piotrowski²,

Waluga³

et al. 2015

ceh

View full text Add to dashboard Cite

Chronic hepatitis C (CHC) is generally a slowly progressive disease, but some factors associated with rapid progression have been identified. Hepatitis C virus (HCV) may contribute to a broad spectrum of metabolic disturbances – namely, steatosis, insulin resistance (IR), increased prevalence of impaired glucose tolerance, type 2 diabetes mellitus (T2DM), lipid metabolism abnormalities and atherosclerosis.HCV can directly or indirectly cause both IR and steatosis, but it is still not resolved whether this viral impact bears the same prognostic value as the metabolic counterparts. As the population exposed to HCV ages, the morbidity due to this disease is increasing. The rising epidemic of obesity contributes to higher prevalence of IR and T2DM. Our understanding of the mutual association between both disease states continues to grow, but is still far from complete. This review briefly discusses the most probable mechanisms involved in IR development in the course of CHC. Molecular mechanisms for the direct and indirect influence of HCV on intracellular insulin signaling are described. Subsequently, the consequences of IR/T2DM for disease progression and management are summarized.

show abstract

“…Indeed, consistent correlations between serum Trx and homeostasis model assessment–insulin resistance (HOMA–IR) index have been described [157]. While data on a potential correlation between oxidative stress markers and steatosis, at least in patients with non-3 HCV genotypes [168,169] remain non-conclusive, a clear interrelation between oxidative stress and insulin resistance is highlighted [168]. Currently it is thought that HCV induces steatosis not only via oxidative stress but also by alternative mechanisms, provoked by the same viral proteins.…”

Section: Oxidative Stress and Hcv-associated Diseasesmentioning

confidence: 99%

HCV and Oxidative Stress in the Liver

Ivanov

Bartosch

Smirnova

et al. 2013

Viruses

177

145

View full text Add to dashboard Cite

Hepatitis C virus (HCV) is the etiological agent accounting for chronic liver disease in approximately 2–3% of the population worldwide. HCV infection often leads to liver fibrosis and cirrhosis, various metabolic alterations including steatosis, insulin and interferon resistance or iron overload, and development of hepatocellular carcinoma or non-Hodgkin lymphoma. Multiple molecular mechanisms that trigger the emergence and development of each of these pathogenic processes have been identified so far. One of these involves marked induction of a reactive oxygen species (ROS) in infected cells leading to oxidative stress. To date, markers of oxidative stress were observed both in chronic hepatitis C patients and in various in vitro systems, including replicons or stable cell lines expressing viral proteins. The search for ROS sources in HCV-infected cells revealed several mechanisms of ROS production and thus a number of cellular proteins have become targets for future studies. Furthermore, during last several years it has been shown that HCV modifies antioxidant defense mechanisms. The aim of this review is to summarize the present state of art in the field and to try to predict directions for future studies.

show abstract

Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

Abstract: In non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress.

Cited by 15 publications

References 50 publications

Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women

Blood Glutathione Peroxidase Activity in Relation with the Risk of Cardiovascular Diseases in Obese Women

Review article Insulin resistance and its consequences in chronic hepatitis C

HCV and Oxidative Stress in the Liver

Contact Info

Product

Resources

About