Insulin resistance and endothelial function in children and adolescents

Miniello, Vito Leonardo; Faienza, Maria Felicia; Scicchitano, Pietro; Cortese, Francesca; Gesualdo, Michele; Zito, Annapaola; Basile, Teresa Maria Altomare; Recchia, Pasquale; Leogrande, Domenico; Viola, Domenico; Giordano, Paola; Ciccone, Marco Matteo

doi:10.1016/j.ijcard.2014.04.115

Cited by 38 publications

(34 citation statements)

References 35 publications

(45 reference statements)

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“…40 The present SGA subjects had statistically significantly higher HOMA-IR compared with the AGA subjects, indicating an insulin-resistant condition that is well known to induce acceleration of the systemic atherosclerotic process. 30 The present SGA subjects had reduced FMD. In our previous study such endothelial dysfunction in SGA patients was found to be related to a dysfunction in endothelial progenitor cells resulting in reduced proliferation and migration of such cells.…”

Section: Tapsesupporting

confidence: 44%

“…Measurements were performed 2 cm above and distal to the umbilicus and expressed in centimeters. 30 Intraobserver variability was good (ICC=0.97).…”

Section: Resultsmentioning

confidence: 95%

“…APAO was defined as the maximum external cross-sectional measurement. 30 It was calculated as the distance between the near and the far walls of the abdominal aorta. Measurements were performed 2 cm above and distal to the umbilicus and expressed in centimeters.…”

Section: Resultsmentioning

confidence: 99%

“…The study was performed using a highresolution ultrasonograph (Philips Sonos 5500) connected to an image analysis system, certified by the National Research Council of Pisa (MVE II), for computing the brachial artery diameter in real-time by analyzing B-mode ultrasound images. 30 All the ultrasound examinations were performed by the same physician in order to reduce observer bias. With the subject in a supine position for at least 10 min, the arm was positioned comfortably in order to identify the humeral artery.…”

Section: Editorial P 818mentioning

confidence: 99%

See 3 more Smart Citations

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Faienza¹,

Brunetti²,

Delvecchio³

et al. 2016

Circ J

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Section: Tapsesupporting

confidence: 44%

“…Measurements were performed 2 cm above and distal to the umbilicus and expressed in centimeters. 30 Intraobserver variability was good (ICC=0.97).…”

Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Section: Editorial P 818mentioning

confidence: 99%

See 2 more Smart Citations

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Faienza¹,

Brunetti²,

Delvecchio³

et al. 2016

Circ J

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“…Reducing these factors by therapeutic interventions would contribute to reduce the risk for developing later metabolic complications. [6]. Glucose intolerance and a positive family history of diabetes in obese young patients account for increased cardiovascular risks; even the characteristics of the mothers (weight, height, diabetes, smoking,…) and of birth (gestational age, length, head circumference, …) were shown to determine early alterations of the aorta in term neonates [7].…”

Section: Introductionmentioning

confidence: 99%

Randomized Study of the Effects of Statin on Inflammatory and Prothrombotic States in Obese Adolescents

Dirlewanger¹,

P²,

Roux‐Lombard³

et al. 2016

Journal of Paediatrics and Neonatal Disorders

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Background: Increased inflammatory cytokines, C-reactive protein (CRP) and prothrombotic parameters are potential markers of cardiovascular risks in childhood obesity. Objectives:We investigated whether a statin treatment can reverse these early cardiovascular risk indicators. The primary outcome was the effect of sixteen weeks of statins on the inflammatory cytokines, CRP and the pro-thrombotic state in obese adolescents. Methods:This randomized controlled double-blind study conducted at the University Hospital of Geneva included 28 obese adolescents aged 12-16 years. Subjects received either placebo (P) or atorvastatin (A) for sixteen weeks. Levels of monocyte chemoattractant protein 1 (MCP-1), interleukin-6, interferon-γ-inducible protein, interleukin-10, interleukin-1 receptor antagonist and CRP were measured at baseline, after sixteen weeks and after one year. Coagulation parameters were evaluated by prothrombin time, activated partial thromboplastin time, fibrinogen levels and endogenous thrombin potential (ETP) at each visit. Results:The MCP-1 level was stable in group A after sixteen weeks of treatment, while it tended to increase in group P (median evolution, 0.2 pg/mL in A vs 34.3 pg/mL in P). The ETP levels decreased in group A and increased in group P (median evolution, -7.0 mA in A vs 12.9 mA in P). These differences of the evolution were not statistically different (MCP-1 p= 0.09, ETP p= 0.07), but after adjustment for age and BMI the ETP evolution reached significance (ETP adjusted, p=0.01). The baseline fibrinogen levels were already high in both groups (median 3.6 g/L, norm < 3.0). No prolonged effects were detected after one year. Conclusions: Increased levels of fibrinogen are already observed in obese adolescents reflecting the procoagluant risk. ETP decreased significantly with atorvastatin treatment in comparison to the non-treated group. Atorvastatin did however not decrease inflammation parameters. Abstract Randomized Study of the Effects of Statin on Inflammatory and Prothrombotic States in Obese Adolescents

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Insulin Resistance and Cardiovascular Disease

Haley

Urbina

2019

Contemporary Endocrinology

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Insulin resistance and endothelial function in children and adolescents

Cited by 38 publications

References 35 publications

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Vascular Function and Myocardial Performance Indices in Children Born Small for Gestational Age

Randomized Study of the Effects of Statin on Inflammatory and Prothrombotic States in Obese Adolescents

Insulin Resistance and Cardiovascular Disease

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