Insulin Intervention in Slowly Progressive Insulin-Dependent (Type 1) Diabetes Mellitus

Abstract

Insulin intervention to preserve beta-cell function is effective and safe for patients with SPIDDM or latent autoimmune diabetes in adults.

Hypoglycemic Effects of Morus alba Leaf Extract on Postprandial Glucose and Insulin Levels in Patients with Type 2 Diabetes Treated with Sulfonylurea Hypoglycemic Agents

“…SU binds to the SU-receptor (SUR) in pancreas beta-cell which consist ATP-dependent potassium channel. On the other hand, SU exhausts the beta-cell due to the oxidation stress, however, Nyback-Nakell et al do not support that SU is harmful to beta-cell function [16], and a small dose of insulin effectively prevent beta-cell failure caused by SUtreatment in type 1 diabetes [17]. The intake of carbohydrate between meals causes higher concentration of blood glucose and then vascular system is exposed oxidative stress.…”

Latent Autoimmune Diabetes in Adults With Low-Titer GAD Antibodies: Similar Disease Progression With Type 2 Diabetes

“…In contrast to type 2 diabetes, a larger proportion of LADA patients progress to insulin treatment, and current therapeutic strategies include the early use of insulin and avoidance of sulfonylurea drugs (4)(5)(6)(7). Despite insulin therapy, individuals with LADA tend to have worse glycemic control than patients with type 2 diabetes (8).…”

Slowly Progressive Insulin-dependent Diabetes Mellitus Associated with Pernicious Anemia

“…Insulin treatment is highly effective for SPIDDM patients with elevated GAD Ab titers (10 U/mL), and preserving β-cell function prevents progression from a non-insulindependent state to total diabetes associated with the complete cessation of insulin secretion (31). In the present our case, we started the patient on insulin injections because of the markedly extremely high titer (2,680 U/mL) of GAD Ab.…”