Slowly Progressive Insulin-dependent Diabetes Mellitus Associated with Pernicious Anemia

Koyama, Jun; Hata, Shoichi; Yamazaki, Hiroyuki; Tajima, Naoko

doi:10.2169/internalmedicine.49.2837

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…We herein describe a patient with pernicious anemia that occurred 8 years after his diagnosis of acute-onset T1D. In addition, all 14 previously reported cases of Japanese patients with concomitant T1D and pernicious anemia are reviewed (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23).…”

Section: Introductionmentioning

confidence: 99%

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

et al. 2015

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We herein report the case of a 66-year-old Japanese man with acute-onset type 1 diabetes mellitus (T1D) accompanied by pernicious anemia. After 2 weeks of polyuria, the patient developed insulin-deficient hyperglycemia with diabetic ketoacidosis in the absence of verifiable islet-related autoantibodies and began insulin therapy in 2001. Eight years later, he developed gastric autoantibody-positive pernicious anemia and began methylcobalamin treatment. Previous studies have reported cases of slowly progressive autoimmune T1D concomitant with pernicious anemia. The present case suggests that potential associations with organ-specific autoimmune disorders should be considered during the long-term follow-up of T1D patients, even though verifiable islet-related autoantibodies are undetectable.

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Section: Introductionmentioning

confidence: 99%

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

et al. 2015

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“…On the other hand, Hibi et al studied 1572 Japanese type 1 diabetes mellitus, thirty-three patients had autoimmune thyroid disease (2.10%) and only one patient had pernicious anemia [7]. Kinoshita et al reported that type 1 diabetes mellitus with coexisting pernicious anemia was approximately 8 cases in Japan [8]. …”

Section: Discussionmentioning

confidence: 99%

Autoimmune Polyglandular Syndrome Type 3 with Anorexia

Kahara

Wakakuri

Takatsuji

et al. 2012

Case Reports in Endocrinology

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A 71-year-old man with diabetes mellitus visited our hospital with complaints of anorexia and weight loss (12 kg/3 months). He had megaloblastic anemia, cobalamin level was low, and autoantibody to intrinsic factor was positive. He was treated with intramuscular cyanocobalamin, and he was able to consume meals. GAD autoantibody and ICA were positive, and he was diagnosed with slowly progressive type 1 diabetes mellitus (SPIDDM). Thyroid autoantibodies were positive. According to these findings, he was diagnosed with autoimmune polyglandular syndrome type 3 with SPIDDM, pernicious anemia, and Hashimoto's thyroiditis. Extended periods of cobalamin deficiency can cause serious complications such as ataxia and dementia, and these complications may not be reversible if replacement therapy with cobalamin is delayed. Although type 1 diabetes mellitus with coexisting pernicious anemia is very rare in Japan, physicians should consider the possibility of pernicious anemia when patients with diabetes mellitus have cryptogenic anorexia with the finding of significant macrocytosis (MCV > 100 fL).

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Slowly Progressive Insulin-dependent Diabetes Mellitus Associated with Pernicious Anemia

Abstract: Abstract

Cited by 2 publications

References 9 publications

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

Type 1 Diabetes Mellitus and Pernicious Anemia in an Elderly Japanese Patient: A Case Report and Literature Review

Autoimmune Polyglandular Syndrome Type 3 with Anorexia

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