Insights into the internal structures of nanogels using a versatile asymmetric-flow field-flow fractionation method

Niezabitowska, Edyta; Town, Adam R.; Sabagh, Bassem; Moctezuma, Marissa D. Morales; Kearns, Victoria; Spain, Sebastian G.; Rannard, Steve; McDonald, Tom O.

doi:10.1039/d0na00314j

Cited by 15 publications

(16 citation statements)

References 43 publications

(65 reference statements)

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“…Indeed online detection is not necessarily well suited with the measurement based on a temporal analysis of Brownian motion. Hydrodynamic size was also achieved on fractions collected after fractionation by AF4 ((B) Figure 2), in a narrow range of retention time [33]. This leads to reliable and precise measurement.…”

Section: Coupling and Detectors Associated With Field-flow Fractionationmentioning

confidence: 99%

“…The value of the ratio of the gyration diameter measured by MALS and the hydrodynamic diameter (or also the hydrodynamic and gyration radii), called shape factor, provides information on the shape, or even on the structure of the analyte. Some typical values of the shape factor for NPs are shown at the top right of Figure 2 [16,33,35,36]. This ratio is usually used for a morphological -Hydrodynamic diameters measured for MWCNT, and 11-350 nm for PLC-MWCNT complex); concentrations determined The fractal dimension structural parameter is defined as the log/log ratio between the molar mass and the gyration radius; and shape factor as the ratio between the gyration and hydrodynamic sizes (expressed either in diameters or in radii; e.g., d g /d h ).…”

Section: Coupling and Detectors Associated With Field-flow Fractionationmentioning

confidence: 99%

“…Four detectors are mainly involved: differential refractometer (dRI), ultra-violet-visible spectrometer (UV-Vis), molecular fluorescence spectrometer (MFD), and inductively coupled plasma mass spectrometer (ICP-MS) (bottom right of Figure 2 for AF4-based coupling). dRI is a detector mainly used for carbon-based NPs typically made of or coated with polymers, natural or synthetic [13,26,33,37,38,40]. However, this detector is of limited sensitivity.…”

Section: F I G U R Ementioning

confidence: 99%

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Field‐flow fractionation for nanoparticle characterization

Lespès

Pont

2021

J of Separation Science

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This review presents field-flow fractionation: The elements of theory enable the link between the retention and the characteristics of the nanometer-sized analytes to be highlighted. In particular, the nature of force and its way of being applied are discussed. Four types of forces which determine four types of techniques were considered: hydrodynamic, sedimentation, thermal, and electrical; this is to show the importance of the choice of technique in relation to the characterization objectives. Then the separation performance is presented and compared with other separation techniques: field-flow fractionation has the greatest intrinsic separation capability. The characterization strategies are presented and discussed; on the one hand with respect to the characteristics needed for the description of nanoparticles; on the other hand in connection with the choice of the nature of the force, and also of the detectors used, online or offline. The discussion is based on a selection of published study examples. Finally, current needs and challenges are addressed, and as response, trends and possible characterization solutions.

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Section: Coupling and Detectors Associated With Field-flow Fractionationmentioning

confidence: 99%

Section: Coupling and Detectors Associated With Field-flow Fractionationmentioning

confidence: 99%

Section: F I G U R Ementioning

confidence: 99%

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Field‐flow fractionation for nanoparticle characterization

Lespès

Pont

2021

J of Separation Science

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“…2-(hydroxyethylthiocarbonothioylthio)-2-methylpropanoic acid (HEMP) was synthesised as previous reported. 79 All other reagents were used as received. SnakeSkin™ dialysis tubing (ThermoFisher scientific) of 3.5 kDa molecular weight cut-off (MWCO) was used to purify the macro-CTAs and nanogel solutions.…”

Section: Synthesis and Properties Of Paa-b-pnipam Block Copolymersmentioning

confidence: 99%

The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

Morales-Moctezuma

Spain

2021

Polym. Chem.

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“…Fast development in synthesis techniques [3][4][5][6][7][8] in the last decade resulted in nano-and microgels responsive to various stimuli such as pH [9,10], temperature [9,11,12], electromagnetic radiation [13], ionic strength or electric fields [11,14]. Among typical responses are swelling/collapse transitions or particular rheological properties [15][16][17][18][19].…”

Section: Introductionmentioning

confidence: 99%

Behaviour of a magnetic nanogel in a shear flow

Novikau¹,

Novak²,

Pyanzina³

et al. 2021

Preprint

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Magnetic nanogels (MNG) -soft colloids made of polymer matrix with embedded in it magnetic nanoparticles (MNPs)are promising magneto-controllable drug carriers. In order to develop this potential, one needs to clearly understand the relationship between nanogel magnetic properties and its behaviour in a hydrodynamic flow. Considering the size of the MNG and typical time and velocity scales involved in their nanofluidics, experimental characterisation of the system is challenging. In this work, we perform molecular dynamics (MD) simulations combined with the Lattice-Boltzmann (LB) scheme aiming at describing the impact of the shear rate ( γ) on the shape, magnetic structure and motion of an MNG. We find that in a shear flow the centre of mass of a MNG tends to be in the centre of a channel and to move preserving the distance to both walls. The MNG monomers along with translation are involved in two more types of motion, they rotate around the centre of mass and oscillate with respect to the latter. It results in synchronised tumbling and wobbling of the whole MNG accompanied by its volume oscillates. The fact the a MNG is a highly compressible and permeable for the carrier liquid object makes its behaviour different from that predicted by classical Taylor-type models. We show that the frequency of volume oscillations and rotations are identical and are growing function of the shear rate. We find that the stronger magnetic interactions in the MNG are, the higher is the frequency of this complex oscillatory motion, and the lower is its amplitude. Finally, we show that the oscillations of the volume lead to the periodic changes in MNG magnetic energy.

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Insights into the internal structures of nanogels using a versatile asymmetric-flow field-flow fractionation method

Abstract: Poly(N-isopropylacrylamide) (pNIPAM) nanogels are a highly researched type of colloidal material. In this work, we establish a versatile asymmetric-flow field-flow fractionation (AF4) method that can provide high resolution particle sizing...

Cited by 15 publications

References 43 publications

Field‐flow fractionation for nanoparticle characterization

Field‐flow fractionation for nanoparticle characterization

The effects of cononsolvents on the synthesis of responsive particles via polymerisation-induced thermal self-assembly

Behaviour of a magnetic nanogel in a shear flow

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