Insights into the effects of tensile and compressive loadings on human femur bone

Havaldar, Raviraj; Pilli, SC; Putti, B.B.

doi:10.4103/2277-9175.129375

Cited by 110 publications

(73 citation statements)

References 19 publications

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“…Scaffold (c) had the lowest dry and wet compressive moduli of 0.40 ± 0.005 and 0.34 ± 0.1 GPa, respectively. The compressive moduli of human cortical femur bone ranges from 0.338 ± 0.179 to 0.404 ± 0.314 GPa and are similar to those recorded in this study. Statistically significant differences were found for each design and for the dry/wet conditions.…”

Section: Resultssupporting

confidence: 85%

Influence of scaffold design on 3D printed cell constructs

et al. 2017

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Additive manufacturing is currently receiving significant attention in the field of tissue engineering and biomaterial science. The development of precise, affordable 3D printing technologies has provided a new platform for novel research to be undertaken in 3D scaffold design and fabrication. In the past, a number of 3D scaffold designs have been fabricated to investigate the potential of a 3D printed scaffold as a construct which could support cellular life. These studies have shown promising results; however, few studies have utilized a low-cost desktop 3D printing technology as a potential rapid manufacturing route for different scaffold designs. Here six scaffold designs were manufactured using a Fused deposition modeling, a "bottom-up" solid freeform fabrication approach, to determine optimal scaffold architecture for three-dimensional cell growth. The scaffolds, produced from PLA, are coated using pullulan and hyaluronic acid to assess the coating influence on cell proliferation and metabolic rate. Scaffolds are characterized both pre- and postprocessing using water uptake analysis, mechanical testing, and morphological evaluation to study the inter-relationships between the printing process, scaffold design, and scaffold properties. It was found that there were key differences between each scaffold design in terms of porosity, diffusivity, swellability, and compressive strength. An optimal design was chosen based on these physical measurements which were then weighted in accordance to design importance based on literature and utilizing a design matrix technique. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 533-545, 2018.

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Section: Resultssupporting

confidence: 85%

Influence of scaffold design on 3D printed cell constructs

et al. 2017

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“…In fact, the compressive strength of the HA dry -derived samples was around 60 MPa, while HA wet -derived materials achieved significantly higher values (around 300 MPa), comparable or even higher than those of human cortical bones 46,47 and suggesting a possible mechanical role in orthopedic applications. In fact, the compressive strength of the HA dry -derived samples was around 60 MPa, while HA wet -derived materials achieved significantly higher values (around 300 MPa), comparable or even higher than those of human cortical bones 46,47 and suggesting a possible mechanical role in orthopedic applications.…”

Section: Resultsmentioning

confidence: 89%

Fabrication of dense and porous biphasic calcium phosphates: Effect of dispersion on sinterability and microstructural development

Mohammadi

Tulliani

Palmero

2019

Int J Applied Ceramic Tech

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The particle size distribution of a commercial Mg‐doped hydroxyapatite powder was tailored through two different milling procedures, carried out under wet or dry conditions. Wet milling gave rise to finer particles, with a narrower size distribution. Tailoring the particles size was the key to produce homogeneous gelcast green bodies, as well as fully dense and fine microstructures. In fact, wet‐milled samples achieved full densification and compressive strength of about 300 MPa, five times higher than the values achieved by the dry milled samples. During the calcination treatments, HA progressively decomposed into β‐ and α‐TCP phases, promoted by the progressive Mg2+ substitution inside the HA and β‐TCP lattices. As a result, a biphasic (HA/β‐TCP) calcium phosphate ceramic was successfully obtained. Gelcast macroporous materials were prepared by direct foaming, starting from both milled powders. Highly porous samples (73%‐77% porosity) with a high degree of interconnectivity within pores were successfully produced. However, dry milled‐foamed materials were characterized by a significant residual porosity within the struts, whereas in wet‐milled foams struts and pore windows were highly compact, the key to provide sufficient mechanical strength to such highly porous open‐cell foams, thus suggesting a possible use as implantable scaffolds.

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“…Niu et al [13] used carbamide particles as space-holders, and the final porosity was 55%-75%. The samples were produced by loose sintering, the Young's modulus of these samples was 3-6.4 GPa, and the plateau stress varied between 10 and 35 MPa [13], which is too low for load-bearing applications, since a typical human bone exhibits a compressive strength ranging between 150 and 300 MPa [14]. In the present work, it will be demonstrated that even samples with high porosity have a high strength when they are produced by hot-pressing instead of sintering.…”

Section: Introductionmentioning

confidence: 99%

Mechanical and Corrosion Behavior of New Generation Ti-45Nb Porous Alloys Implant Devices

et al. 2016

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Strategies to improve the mechanical compatibility of Ti-based materials for hard tissue implant applications are directed towards significant stiffness reduction by means of the adjustment of suitable β-phases and porous device architectures. In the present study, the effect of different compaction routes of the gas-atomized β-Ti-45Nb powder on the sample architecture, porosity, and on resulting mechanical properties in compression was investigated. Green powder compacted and sintered at 1000 • C had a porosity varying between 8% and 12%, strength between 260 and 310 MPa, and Young's modulus ranging between 18 and 21 GPa. Hot pressing of the powder without or with subsequent sintering resulted in microporosity varying between 1% and 3%, ultimate strength varying between 635 and 735 MPa, and Young's modulus between 55 and 69 GPa. Samples produced with NaCl space-holder by hot-pressing resulted in a macroporosity of 45% and a high strength of >200 MPa, which is higher than the strength of a human cortical bone. Finally, the corrosion tests were carried out to prove that the presence of residual NaCl traces will not influence the performance of the porous implant in the human body.

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Insights into the effects of tensile and compressive loadings on human femur bone

Cited by 110 publications

References 19 publications

Influence of scaffold design on 3D printed cell constructs

Influence of scaffold design on 3D printed cell constructs

Fabrication of dense and porous biphasic calcium phosphates: Effect of dispersion on sinterability and microstructural development

Mechanical and Corrosion Behavior of New Generation Ti-45Nb Porous Alloys Implant Devices

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