Insights into media supplementation in solid-state fermentation of soybean hulls by Yarrowia lipolytica: Impact on lipase production in tray and insulated packed-bed bioreactors

Nascimento, Felipe; Castro, Aline Machado de; Secchi, Argimiro Resende; Coelho, Maria Alice Zarur

doi:10.1016/j.bej.2020.107866

Cited by 13 publications

(6 citation statements)

References 45 publications

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“… Network visualization map for the co-occurrence of works that bring information about the scale-up process using lipases applied to bioprocesses [ 41 , 99 , 100 , 101 , 102 , 103 , 104 , 105 , 106 , 107 , 108 , 109 , 110 , 111 , 112 , 113 , 114 ]. Publications in the period from 2018 to 2022 were considered.…”

Section: Figurementioning

confidence: 99%

Trends in the Use of Lipases: A Systematic Review and Bibliometric Analysis

Santos

Vieira

Almeida

et al. 2023

Foods

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Scientific mapping using bibliometric data network analysis was applied to analyze research works related to lipases and their industrial applications, evaluating the current state of research, challenges, and opportunities in the use of these biocatalysts, based on the evaluation of a large number of publications on the topic, allowing a comprehensive systematic data analysis, which had not yet been conducted in relation to studies specifically covering lipases and their industrial applications. Thus, studies involving lipase enzymes published from 2018 to 2022 were accessed from the Web of Science database. The extracted records result in the analysis of terms of bibliographic compatibility among the articles, co-occurrence of keywords, and co-citation of journals using the VOSviewer algorithm in the construction of bibliometric maps. This systematic review analysis of 357 documents, including original and review articles, revealed studies inspired by lipase enzymes in the research period, showing that the development of research, together with different areas of knowledge, presents good results related to the applications of lipases, due to information synchronization. Furthermore, this review showed the main challenges in lipase applications regarding increased production and operational stability; establishing well-defined evaluation criteria, such as cultivation conditions, activity, biocatalyst stability, type of support and reactor; thermodynamic studies; reuse cycles; and it can assist in defining goals for the development of successful large-scale applications, showing several points for improvement of future studies on lipase enzymes.

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Section: Figurementioning

confidence: 99%

Trends in the Use of Lipases: A Systematic Review and Bibliometric Analysis

Santos

Vieira

Almeida

et al. 2023

Foods

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“…The temperature often reaches values which severely limit growth or even kill the microorganims [8,19,65,70,71]. High temperatures might affect spore germination and growth, and product formation.…”

Section: Heat Evolution As a Mechanism To Describe Fungal Growthmentioning

confidence: 99%

“…The growth rate was expressed solely as a function of the current temperature according to the experimental results. The increment of temperature during SSF in the tray and the insulated packed-bed bioreactors was responsible for changes in the use of the soybean oil and in protease secretion by Yarrowia lipolytica [8]. A strategy that uses intermittent trickling of water in the bed bioreactor, results in good temperature control, avoiding the bed from drying, preventing substrate compaction, as well as increased Aspergillus ficuum mycelium growth and phytase production [13].…”

Section: Heat Evolution As a Mechanism To Describe Fungal Growthmentioning

confidence: 99%

“…A number of SSB designs exist for SSF, such as semi-continuous plug-flow [2], packed-bed [3][4][5][6][7], tray [8][9][10][11][12], trickle bed [13], multipurpose fixed-bed [14], rotating drum [9,15], horizontal drum [16], column-tray [17], novel deep-bed cubical [18], multi-layer packed-bed [19], column [20], fluidised-bed [21], hexahedral modular [22], SSF reactor (SSFR) [23], horizontal rotary drum [24], continuous counter-current [25], scrapped-drum [26], zymotis packed-bed [27], gas-solid spouted-bed [28], horizontal stirred tank [29], vertical cylindrical shaped (fed-batch SSF) [30] and cylindrical [31] bioreactors. Progress has been made in improving processes at the laboratory level, but research on bioreactor designs and process scale-ups that allow the usage of microorganisms needs further focus [32].…”

Section: Introductionmentioning

confidence: 99%

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Performance of Fungal Growth Through Integrated Gompertz Model and Respiratory Quotient by Solid State Fermentation in Multi-Layer Squared Tray Solid State Bioreactor with Aeration Strategies

Manan

Webb

2021

Preprint

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A newly designed, laboratory-scaled and multi-layer squared tray solid state bioreactor (SSB), was developed and successfully operated in solid state fermentation (SSF) conditions. The bioreactor was divided into eight layers of squared perforated trays. Wheat bran was used as a solid substrate for the growth of Aspergillus awamori and Aspergillus oryzae. The SSB was equipped with an oxygen (O2)/carbon dioxide (CO2) gas analyser and a thermocouple. Continuous on-line monitoring of fungal growth could be performed by indirect methods that measure O2 consumed, production of CO2 and metabolic heat. The advantage of using this method is that there are no tedious and time-consuming sampling processes. The evolution of CO2, which represents an accumulation term, was integrated with time and fitted to the Gompertz model in a log-like equation. The Gompertz model generated values that may be used to stimulate and verify the experimental data. Results strongly suggest that the evolved and accumulated CO2, excellently described fungal growth. Simulated results agreed with experimental results. The respiratory quotient (RQ), which is the ratio of CO2 evolution rate (CER) to O2 uptake rate (OUR), was determined by the gas balance method. CER and OUR confirmed that measurements correlated to fungal activity. Each RQ values can explain the differences of each SFF process carried out. Yet, heat evolved by fungal activity also described fungal growth. The current findings is an excellent pre-liminary experimental work, evidencing that multi-layer squared tray SSB with forced moistened aeration present a promising alternative of instrumented bioreactors for SSF processes.

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“…Residues from soybean (Glycine max), olive (Olea europaea), and other systems could be employed [14]. When the residues lack any component for microbial development, medium supplementation can also be used to fulfill these requirements [15].…”

Section: Introductionmentioning

confidence: 99%

A Temporal Evolution Perspective of Lipase Production by Yarrowia lipolytica in Solid-State Fermentation

et al. 2022

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Lipases are enzymes that, in aqueous or non-aqueous media, act on water-insoluble substrates, mainly catalyzing reactions on carboxyl ester bonds, such as hydrolysis, aminolysis, and (trans)esterification. Yarrowia lipolytica is a non-conventional yeast known for secreting lipases and other bioproducts; therefore, it is of great interest in various industrial fields. The production of lipases can be carried on solid-state fermentation (SSF) that utilizes solid substrates in the absence, or near absence, of free water and presents minimal problems with microbial contamination due to the low water contents in the medium. Moreover, SSF offers high volumetric productivity, targets concentrated compounds, high substrate concentration tolerance, and has less wastewater generation. In this sense, the present work provides a temporal evolution perspective regarding the main aspects of lipase production in SSF by Y. lipolytica, focusing on the most relevant aspects and presenting the potential of such an approach.

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Insights into media supplementation in solid-state fermentation of soybean hulls by Yarrowia lipolytica: Impact on lipase production in tray and insulated packed-bed bioreactors

Cited by 13 publications

References 45 publications

Trends in the Use of Lipases: A Systematic Review and Bibliometric Analysis

Trends in the Use of Lipases: A Systematic Review and Bibliometric Analysis

Performance of Fungal Growth Through Integrated Gompertz Model and Respiratory Quotient by Solid State Fermentation in Multi-Layer Squared Tray Solid State Bioreactor with Aeration Strategies

A Temporal Evolution Perspective of Lipase Production by Yarrowia lipolytica in Solid-State Fermentation

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