2019
DOI: 10.1016/j.ijbiomac.2019.08.242
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Insight into the binding of a synthetic nitro-flavone derivative with human poly (ADP-ribose) polymerase 1

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Cited by 10 publications
(11 citation statements)
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“…ACPH, a potential anticancer agent with PARP1 inhibitory properties have been shown to potentiate the killing by cisplatin to make it effective at lower doses [5]. We have seen earlier that 4NCO can bind to the NAD + binding pocket of PARP1 enzyme to act as its inhibitor [7]. 4NCO exhibited limited toxicity in normal cells, but was effective in inducing killing in cancer cell lines and was most found to be most effective in A375 melanoma cells as obtained from our earlier ndings [34].…”
Section: Discussionmentioning
confidence: 99%
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“…ACPH, a potential anticancer agent with PARP1 inhibitory properties have been shown to potentiate the killing by cisplatin to make it effective at lower doses [5]. We have seen earlier that 4NCO can bind to the NAD + binding pocket of PARP1 enzyme to act as its inhibitor [7]. 4NCO exhibited limited toxicity in normal cells, but was effective in inducing killing in cancer cell lines and was most found to be most effective in A375 melanoma cells as obtained from our earlier ndings [34].…”
Section: Discussionmentioning
confidence: 99%
“…Molecular docking provides possible insight into the binding of any ligand to its receptor. The whole human PARP1 protein (PDB ID: 4DQY, resolution: 3.25 Å) was downloaded from https://www.rcsb.org/ as described earlier [7][18] [19]. The bound DNA structure was removed and the protein structure was re ned using the 'clean protein' tool in Discovery Studio (DS) 2.5 platform where the missing atom residues were added and waters were removed.…”
Section: Molecular Docking Studiesmentioning
confidence: 99%
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