Insight into anticholinesterase and antioxidant potential of thirty-four Rosaceae samples and phenolic characterization of the active extracts by HPLC

Ekin, Hasya Nazlı; Gökbulut, Alper; Aydın, Zübeyde Uğurlu; Dönmez, Ali A.; Orhan, İlkay Erdoğan

doi:10.1016/j.indcrop.2016.06.029

Cited by 25 publications

(27 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Phenolic compounds are important secondary metabolites widely found in seeds like P . ostii , other plant organs (fruit and leaf), and processed plant products, which have multiple biological effects, such as antioxidant activity . Epidemiological studies suggested that the ingestion of phenolic compounds through either natural sources or dietary supplements was significantly associated with risk reduction of cardiovascular diseases, neurodegenerative disorders, and cancer development .…”

Section: Introductionmentioning

confidence: 99%

Variation in Phenolic Content, Profile, and Antioxidant Activity of Seeds among Different Paeonia ostii Cultivated Populations in China

Zhang

Jin

et al. 2018

Chemistry & Biodiversity

View full text Add to dashboard Cite

The purpose of this study was to analyze the phenolic profiles of seeds from fifteen Paeonia ostii cultivated populations in China and identify their relationship with antioxidant activities and associated environmental factors. Thirteen individual phenolic compounds were quantitatively determined by HPLC, and (+)-catechin was the most abundant phenolic compound in the seeds. Correlation analysis showed that phenolics were the most effective antioxidant compound class by evaluating DPPH, ABTS, and hydroxyl radical scavenging activities as well as ferric reducing antioxidant power. Latitude and annual rainfall had significant effects on the contents of many phenolic compounds, and elevation was only significantly correlated with gallic acid content. Within fifteen P. ostii cultivated populations, the seeds of Tongling population exhibited the highest phenolic contents and strongest antioxidant activities. These results suggest that Tongling population has a relatively high utilization value and a potential for sources of natural antioxidants.

show abstract

Section: Introductionmentioning

confidence: 99%

Variation in Phenolic Content, Profile, and Antioxidant Activity of Seeds among Different Paeonia ostii Cultivated Populations in China

Zhang

Jin

et al. 2018

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…As presented in Table 1 , and Figure 3 , the structurally diverse flavonoids are derivatives of flavonol ( 1–9 ), flavone ( 10–15 ), flavanone ( 16–19 ), flavanol ( 23–25 ), and isoflavone ( 20–22 ). The leaves, flowers, and fruits were found to be particularly rich in flavonols, mainly kaempferol and quercetin mono- and diglycosides, containing glucose, galactose, and rhamnose as the sugar moiety [ 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 ]. Regarding individual components, isoquercitrin ( 2 ), hyperoside ( 3 ), quercitrin ( 4 ), and rutin ( 5 ) were identified as the dominant flavonoids of the leaves, flowers, and fruits ( Table 1 ).…”

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

“…Two different groups of phenolic acids ( Figure 4 ), including trans -cinnamic and benzoic acids derivatives, were identified in the genus Cotoneaster . The typical representatives of these phenolics are caffeoylquinic acids such as chlorogenic acid ( 28 ) and its isomers, ferulic ( 29 ), caffeic ( 30 ), p -coumaric ( 31 ), cinnamic acids ( 32 ) as well as benzoic ( 33 ), protocatechuic ( 34 ), vanillic ( 35 ), gentisic ( 36 ), syringic ( 37 ), p -hydroxybenzoic ( 38 ), and salicylic acids ( 39 ) [ 5 , 7 , 13 , 15 , 20 , 21 , 23 , 26 ]. In addition, a gentisic acid 2- O -glucoside named orbicularin ( 40 ) was isolated from the leafy twigs of C. orbicularis , while caffeoylmalic acid ( 41 ) was obtained from the leaves of C. zabelii [ 15 , 17 ].…”

Section: Phytochemical Composition Of the Genus Cotoneasmentioning

confidence: 99%

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Kicel

2020

Antioxidants

View full text Add to dashboard Cite

Traditional herbal medicines have become a subject of global importance with both medical and economic implications. The regular consumption of herbal drugs has led to serious concerns regarding their quality, effectiveness, and safety. Thus, relevant scientific evidence has become an important criterion for the acceptance of traditional health claims. The genus Cotoneaster Medikus provides numerous species traditionally used in Asian medicine for the treatment of haemorrhoids, diabetes, and cardiovascular diseases. This review summarises the achievements of modern research on the Cotoneaster taxa, including ethnobotany, phytochemistry, pharmacology, and toxicology. To date, more than 90 compounds have been isolated or analytically identified in Cotoneaster leaves, fruits, flowers or twigs. These phytochemicals are categorised into flavonoids, procyanidins, phenolic acids, cotonefurans, cyanogenic glycosides, triterpenes, sterols, fatty acids, volatile compounds, and carbohydrates, and many of them are responsible for Cotoneaster pharmacological properties including antioxidant, anti-inflammatory, antimicrobial, antiparasitic, hepatoprotective, anti-diabetic or anti-dyslipidaemic activity. In order to ensure the safety of pharmaceutical applications, the potential toxicity of Cotoneaster extracts has also been investigated. In conclusion, this systematic review provides an important reference base for further study into the various medical applications of both the dry extracts and pure isolates of Cotoneaster species.

show abstract

“…They concluded that beneficial effect can be explained by the antioxidant activity of the extract connected with the presence of polyphenols. Moreover, Ekin et al (2016) used 75 % ethanolic extract to test acetylcholinesterase inhibitory activity of thirty-four Rosaceae samples among them of 7 Sorbus species collected on different localities in Turkey. Extracts of S. umbelleta collected in two different localities had high inhibition potential against AChE i.e.…”

Section: Evaluation Of Antineurodegenerative Activitiesmentioning

confidence: 99%

Biological activities of Sorbus aucuparia L. leaves extract

et al. 2018

View full text Add to dashboard Cite

Biological activities of Sorbus aucuparia L. leaves extract were tested in our study. Antineurodegenerative activity was evaluated by acetylcholinesterase (AChE) and tyrosinase (TYR) inhibitory activity assays while antioxidant activity was tested using four different assays (DPPH, ABTS, FRAP, and βcarotene test). In all antioxidant tests, concentration-dependent activity of leaves extract was noticed and the highest applied concentration (500 µg/ml) was the most active. Extract applied in a concentration of 200 µg/ml showed higher percent of DPPH inhibition compared with both concentrations of standard substances BHA and BHT (50 and 100 µg/ml). In the ABTS test, the activity of extract applied in 500 µg/ml was comparable or higher than BHA and BHT/Vitamin C, respectively. Moreover, all concentrations of tested extract were significantly more active in the β-carotene test than vitamin C. The lowest concentration of extract (100 µg/ml) was the most active in TYR assay reaching 42.57 % of the inhibition while in AChE assay there was not statistically significant differences among all applied concentrations.

show abstract

Insight into anticholinesterase and antioxidant potential of thirty-four Rosaceae samples and phenolic characterization of the active extracts by HPLC

Cited by 25 publications

References 28 publications

Variation in Phenolic Content, Profile, and Antioxidant Activity of Seeds among Different Paeonia ostii Cultivated Populations in China

Variation in Phenolic Content, Profile, and Antioxidant Activity of Seeds among Different Paeonia ostii Cultivated Populations in China

An Overview of the Genus Cotoneaster (Rosaceae): Phytochemistry, Biological Activity, and Toxicology

Biological activities of Sorbus aucuparia L. leaves extract

Contact Info

Product

Resources

About