Inorganic elements in occupational settings: A review on the effects on telomere length and biology

Kahl, Vivian Francília Silva; Silva, Juliana da

doi:10.1016/j.mrgentox.2021.503418

Cited by 5 publications

(3 citation statements)

References 142 publications

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“…These results are in accordance with a previous article which highlighted that some inorganic contaminant (e.g. As, Pb, Cr) seem to cause telomere shortening and others telomere elongation (Kahl & da Silva, 2021;H. Li et al, 2012).…”

Section: Liver Proteome Responsesupporting

confidence: 93%

Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

Beauvieux,

Fromentin,

Romero

et al. 2024

Environmental Pollution

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Section: Liver Proteome Responsesupporting

confidence: 93%

Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

Beauvieux,

Fromentin,

Romero

et al. 2024

Environmental Pollution

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“…In our study, although there were not any differences in TL between men and women in the same age group, we found that TL was better maintained in females than males with the age increase. TL was dynamically attritted with age and affected by a variety of environmental factors, such as occupational exposures [37], household income [35], and lifestyle (dietary patterns, drinking, smoking, and physical activity) [38][39][40]. Generally, males have higher risk to occupational exposures, higher rate of drinking and smoking, accounting for their accelerated telomere attrition in relative to females.…”

Section: Discussionmentioning

confidence: 99%

Telomere length is maternally inherited and associated with lipid metabolism in Chinese population

Guo

Chen

et al. 2022

Aging

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Telomere is a unique DNA-protein complex which covers the ends of chromosomes to avoid end fusion and maintain the stability and integrity of chromosomes. Telomere length (TL) shortening has been linked to aging and various age-related diseases in humans. Here we recruited a total of 1031 Chinese individuals aged between 12 and 111 years, including 108 families with parents and their offspring. DNA was extracted from peripheral white blood cells and TL was measured by quantitative PCR (qPCR). We explored the associations of TL with age, gender and clinical variables, and tested the parental effects on TL variation. First, we found that TL was shortened with age, however, TL was better maintained in females than males. Second, there was a robust association of TL between mother and offspring, but not between father and their offspring. In addition, TL was inversely associated with visceral fat index in females, and positively associated with apolipoprotein A levels. Knockdown of the key genes for lipid metabolism ( PNPLA2 and CPT1 ) shortened the TL in HepG2 cells. These findings indicate that TL is maternally inherited, and impairment of lipid metabolism may contribute to the TL shortening in the Chinese population.

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“…Welding fumes are a byproduct of the process, and the rate of generation and the composition of welding fumes are characteristic of the different materials being welded and the soldering components used [ 2 ]. Ultrafine and fine welding particles often consist of numerous metals, including iron (Fe), lead (Pb), zinc (Zn), nickel (Ni), copper (Cu), manganese (Mn), cobalt (Co), cadmium (Cd), and chromium (Cr) [ 3 ]. The size of the welding particles generated differs based on the industrial processes undertaken.…”

Section: Introductionmentioning

confidence: 99%

Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study

Chen

et al. 2023

Metabolites

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The workers exposed to metal fumes had an increased risk of metabolic syndrome, which was correlated with decreased serum adiponectin. Thus, we aimed to explore whether heavy metal exposure affects the adiponectin level. There were 96 male workers recruited from a shipyard at baseline. Apart from 82 participants completed the follow-up assessments, new participants were recruited in next year. Finally, there were 100 welding workers in the exposure group and 31 office workers in the control group. Inferential statistics on repeated measures were performed using generalized estimating equations. A weighted quantile sum (WQS) regression model was conducted to examine the joint effect of the multimetal exposure with serum adiponectin. Significantly negative associations of metals with adiponectin were detected in the welding workers, including Cr (β = −0.088; 95% CI: −0.148, −0.027), Mn (β = −0.174; 95% CI: −0.267, −0.081), Co (β = −0.094; 95% CI: −0.158, −0.029), Ni (β = −0.108; 95% CI: −0.208, −0.008), Cd (β = −0.067; 95% CI: −0.115, −0.018), and Pb (β = −0.089; 95% CI: −0.163, −0.015). The WQS regression suggested that Pb was the greatest contributor. In conclusion, our findings highlighted that welding workers exposed to heavy metals would reduce serum adiponectin.

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Inorganic elements in occupational settings: A review on the effects on telomere length and biology

Cited by 5 publications

References 142 publications

Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

Molecular fingerprint of gilthead seabream physiology in response to pollutant mixtures in the wild

Telomere length is maternally inherited and associated with lipid metabolism in Chinese population

Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study

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