Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study

Wu, Chen‐Jung; Ho, A-Chuan; Chen, Shih-Ya; Pan, Chih-Hong; Chuang, Hsiao-Chi; Lai, Chao Hung

doi:10.3390/metabo13020158

Cited by 4 publications

(3 citation statements)

References 36 publications

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“…In a study conducted on welders in Canada, the prevalence of pre-obesity and obesity was 61% [20]. In Taiwan, welders' average body mass index was 25.2 [21]. In the United States, pre-obesity prevalence among workers was 36.1%, obesity was 22.0%, and the mean body mass index was 26.2.…”

Section: Discussionmentioning

confidence: 99%

Effects of occupational exposure on the hematologic parameters among welders

Medeni,

Çetintepe,

Aygür

et al. 2024

Acta Medica

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Introduction: The effect of prolonged exposure to welding fumes on blood levels remains an unresolved question. In our study, we aimed to determine the effects of metal fume exposure on various blood parameters in welders. Materials and Methods: The study was cross-sectional. It included all male welding workers admitted to a health institution, a reference hospital for occupational diseases, for 2021. It was conducted with 254 individuals. The variables examined included age, duration of employment, smoking habit, body mass index, hemoglobin levels, erythrocyte, leukocyte and platelet counts, aspartate aminotransferase, alanine aminotransferase, free prostate-specific antigen, creatinine and manganese levels, and erythrocyte sedimentation rates. Results: In our study, 40.6% of the welders were between 21-30 years old. 65.7% of the participants have been welding for more than five years. According to body-mass index values, 44.1% of the participants were pre-obese, and 16.9% were obese. 63.8% of the participants were smokers. In 35.8% of participants, hyperglycemia was present, and polycythemia was present in 27.2%. When blood parameters were analyzed, fasting blood glucose, aspartate transaminase, alanine transaminase, and sedimentation rate were lower in those who worked less than five years than those who worked five years or more. The difference was statistically significant. In blood test results, leukocyte, glucose, aspartate transaminase, alanine transaminase, and sedimentation rate values in welders were correlated with total working time. Conclusion: Welders in our study had a high prevalence of smoking, overweight, and obesity. Working time is correlated with liver enzyme levels and fasting blood glucose values. For healthier workers, employers should fulfill their responsibilities for occupational health and safety.

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Section: Discussionmentioning

confidence: 99%

Effects of occupational exposure on the hematologic parameters among welders

Medeni,

Çetintepe,

Aygür

et al. 2024

Acta Medica

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“…Epidemiologic studies have investigated the relationship between Pb or Cd and serum adiponectin. An occupational study of 100 welding workers in Taiwan found that those with higher urinary levels of heavy metals, including Pb and Cd, had lower levels of serum adiponectin, suggesting that Pb exposure may be the main contributor to this association [21]. However, studies on the general population have yielded mixed results.…”

Section: Discussionmentioning

confidence: 99%

“…Previous experimental studies have consistently indicated that exposure to high doses of Pb or Cd can adversely impact adiponectin levels [19,20]. Moreover, an occupational study involving welders exposed to heavy metals, including Pb and Cd, also reported lower levels of serum adiponectin [21]. However, research on the association between Pb or Cd exposure and adiponectin levels in the general population remains limited and inconclusive.…”

Section: Introductionmentioning

confidence: 99%

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

Lin,

Wang,

Sung

et al. 2023

Nutrients

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Previous studies reported that lead (Pb) and cadmium (Cd) exposure are linked to changes in serum adiponectin; an adipokine that promotes glycolysis and inhibits gluconeogenesis to regulate glucose metabolism. However, no study has ever explored the relationship between exposure to these two heavy metals and adiponectin in adolescents and young adults. Additionally, the role of adiponectin in the relationship between Pb and Cd exposure and vascular endothelial cell apoptosis has never been investigated. In this study, 724 Taiwanese participants, aged 12 to 30 years, were enrolled to investigate the association among urinary lead and cadmium, serum adiponectin, and apoptotic microparticles (CD31+/CD42a−, CD31+/CD42a+, and CD14). The results of the current study revealed a statistically significant inverse association between urine Pb and Cd levels and adiponectin levels, as well as a positive association with apoptotic microparticles (CD31+/CD42a−, CD31+/CD42a+, and CD14). Adiponectin was also inversely correlated with CD31+/CD42a− and CD31+/CD42a+. Moreover, when subjects with both Pb and Cd levels above the 50th percentile were compared to those below it, the former group exhibited the lowest average adiponectin value. Additionally, a more pronounced positive association between heavy metals and apoptotic microparticles (CD31+/CD42a− and CD31+/CD42a+) was observed when adiponectin levels were lower. Furthermore, an interaction between adiponectin and heavy metals was identified in the relationship between these metals and CD31+/CD42a−. In conclusion, these findings suggest that Pb and Cd exposure may have an adverse effect on adiponectin, and it may play a role in the link between heavy metal exposure and the dysfunction of vascular endothelial cells. Future studies are needed to establish whether a causal relationship exists.

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Lead exposure suppresses the Wnt3a/β-catenin signaling to increase the quiescence of hematopoietic stem cells via reducing the expression of CD70 on bone marrow-resident macrophages

Zhao,

Wu,

et al. 2023

Toxicological Sciences

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Lead (Pb) is a heavy metal highly toxic to human health in the environment. The aim of this study was to investigate the mechanism of Pb impact on the quiescence of hematopoietic stem cells (HSC). WT C57BL/6 (B6) mice treated with 1250 ppm Pb via drinking water for 8 wk had increased the quiescence of HSC in the bone marrow (BM), which was caused by the suppressed activation of the Wnt3a/β-catenin signaling. Mechanically, a synergistic action of Pb and IFNγ on BM-resident macrophages (BM-Mφ) reduced their surface expression of CD70, which thereby dampened the Wnt3a/β-catenin signaling to suppress the proliferation of HSC in mice. In addition, a joint action of Pb and IFNγ also suppressed the expression of CD70 on human Mφ to impair the Wnt3a/β-catenin signaling and reduce the proliferation of human HSC purified from umbilical cord blood (UCB) of healthy donors. Moreover, correlation analyses showed that the blood Pb concentration was or tended to be positively associated with the quiescence of HSC, and was or tended to be negatively associated with the activation of the Wnt3a/β-catenin signaling in HSC in human subjects occupationally exposed to Pb. Collectively, these data indicate that an occupationally relevant level of Pb exposure suppresses the Wnt3a/β-catenin signaling to increase the quiescence of HSC via reducing the expression of CD70 on BM-Mφ in both mice and humans.

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Exposure to Heavy Metals and Serum Adiponectin Levels among Workers: A 2-Year Follow-Up Study

Cited by 4 publications

References 36 publications

Effects of occupational exposure on the hematologic parameters among welders

Effects of occupational exposure on the hematologic parameters among welders

The Association among Urinary Lead and Cadmium, Serum Adiponectin, and Serum Apoptotic Microparticles in a Young Taiwanese Population

Lead exposure suppresses the Wnt3a/β-catenin signaling to increase the quiescence of hematopoietic stem cells via reducing the expression of CD70 on bone marrow-resident macrophages

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