Inocoterone and acne. The effect of a topical antiandrogen: results of a multicenter clinical trial

Topical Cyproterone Acetate Treatment in Women With Acne

“…17 Finally, the new topical nonsteroidal antiandrogen inocoterone acetate has produced only modest clinical effects in the treatment of acne. 18 Evidence suggests that not all patients with acne exhibit elevated serum androgen levels. 19 Rather, several studies have indicated an increased local formation of androgens, disturbances of the androgen metabolism, 20 or an increased sensitivity of the androgen receptor to normal levels of androgens.…”

The role of androgen and androgen receptor in skin-related disorders

“…The effects of flutamide on acne were observed mainly in patients with hirsutism and satisfactory results were observed for both conditions [95]. Although topical inocoterone treatment can reduce the size of sebaceous glands in the experimental animals [66], the clinical studies did not show significant effect to improve acne [66]. However, inocoterone indeed reduces the inflammatory acne lesions [66], likely due to suppression of AR function to dampen the inflammatory response [36,61].…”

“…Although topical inocoterone treatment can reduce the size of sebaceous glands in the experimental animals [66], the clinical studies did not show significant effect to improve acne [66]. However, inocoterone indeed reduces the inflammatory acne lesions [66], likely due to suppression of AR function to dampen the inflammatory response [36,61]. Although in vitro studies with human SZ95 sebocytes and HaCaT keratinocytes, cyproterone acetate did not show significant effect on the testosterone-induced proliferation [97], but both topical and oral cyproterone acetate treatments improve acne lesions.…”

Update and Future of Hormonal Therapy in Acne

“…It has also been hypothesized that androgens may play a role in follicular hyperkeratinization in acne in addition to their effects on stimulating sebum secretion [1, 2]. Indirect evidence in support of this hypothesis includes the finding of androgen receptors in the outer root sheath of sebaceous follicles, the clinical observation that antiandrogens may reduce follicular casts and the finding of activity of androgen-metabolizing enzymes such as 3β-HSD, 17β-HSD and 5α-reductase in follicles.…”

“…Hormones are best known for their effects on sebum excretion. It has also been suggested that hormones may play a role in the follicular hyperkeratinization seen in follicles affected by acne [1, 2, 3]. From a therapeutic standpoint, the importance of the role of hormones in acne is supported by the clinical efficacy of hormonal therapy in women with acne.…”