Topical Cyproterone Acetate Treatment in Women With Acne

Gruber, Doris; Sator, Michael; Joura, Elmar A.; Kokoschka, E. M.; Heinze, Georg; Huber, Johannes

doi:10.1001/archderm.134.4.459

Cited by 54 publications

(16 citation statements)

References 22 publications

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“…These data were also confirmed by a photo documentation. The maximum clinical effect was seen between the third and sixth months of treatment, a finding that is in conformity with the literature [11]. …”

Section: Discussionsupporting

confidence: 91%

“…A number of OCs contain a 19-nortestosterone derivative as the progesterone, which has certain androgenic properties. There are two substances which are effective in controlling acne: first, cyproterone acetate, a potent steroidal antiandrogen with progestational activity [11]; second, so-called progestins such as desogestrel and norgestimate. Desogestrel has a low androgenic activity and a low affinity for the androgenic receptor.…”

Section: Introductionmentioning

confidence: 99%

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Clinical Evidence of the Endocrinological Influence of a Triphasic Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol in Treating Women with Acne vulgaris

2003

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Background and Objective: The aim of this study was to evaluate the efficacy of a triphasic combination oral contraceptive (OC) containing norgestimate and ethinyl estradiol in the treatment of women with acne vulgaris. Methods: 12 female patients were included and 10 completed the trial. Over a period of 6 months, efficacy was assessed by means of facial acne lesion counts, by an investigator’s global assessment, by patients’ self-assessments and by measuring epidermal moisture and skin surface lipids. In addition, a photo documentation was compiled and hormone levels were measured. Results: After 6 months of therapy, the number of acne counts improved. The success of treatment was rated positively both by the investigator and by all patients but one who did not report any changes. Skin surface lipids were significantly reduced while skin hydration showed no significant change. Testosterone and progesterone decreased, and sex-hormone-binding globulin increased, significantly. Conclusion: Our data show that an OC containing norgestimate and ethinyl estradiol is a good therapeutic option for women of fertile age suffering from mild to moderate acne vulgaris.

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Clinical Evidence of the Endocrinological Influence of a Triphasic Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol in Treating Women with Acne vulgaris

2003

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“…This also seems to be a reasonable range of impact given that prescription acne therapies typically improve Leeds acne scores by 1.0 to 1.2. 25,26 Not surprisingly, students perceived significantly more stress during examinations when compared with the beginning of the academic quarter, when there were no examinations (PϽ.01). Only 2 students reported lower stress levels during the examination period.…”

Section: Resultsmentioning

confidence: 98%

The Response of Skin Disease to Stress

Chon²,

2003

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Background: Although emotional stress has long been suspected to exacerbate acne vulgaris, previous reports addressing its influence on acne severity have been mainly anecdotal.Objectives: To elucidate the possible relationship between stress and acne exacerbation by evaluating changes in acne severity during nonexamination and examination periods and to assess the possible relationship of these changes in severity with perceived examination stress by using previously validated scales measuring acne severity and perceived stress.

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“…Recently, Gruber et al [50] have undertaken an open, placebo-controlled clinical trial (n = 40) in order to compare the effectiveness of a topical liposomal CPA formulation with an oral formulation containing 0.035 mg of ethynyl estradiol and 2 mg of CPA, and a placebo preparation in women with moderate to severe acne. Mean facial acne grades of the participants were quantitated for determining the effi cacy of oral and topical CPA formulations.…”

Section: Overview Of Various Novel Drug Delivery Strategiesmentioning

confidence: 99%

Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents

Date

Naik²,

Nagarsenker³

2005

Skin Pharmacol Physiol

106

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Acne is the most common cutaneous disorder of multifactorial origin with a prevalence of 70–85% in adolescents. The majority of the acne sufferers exhibit mild to moderate acne initially, which progresses to the severe form in certain cases. Topical therapy is employed as first-line treatment in mild acne, whereas for moderate and severe acne, systemic therapy is required in addition to topical therapy. Currently, several topical agents are available that affect at least one of the main pathogenetic factors responsible for the development of acne. Although topical therapy has an important position in acne treatment, side effects associated with various topical antiacne agents and the undesirable physicochemical characteristics of certain important agents like tretinoin and benzoyl peroxide affect their utility and patient compliance. Novel drug delivery strategies can play a pivotal role in improving the topical delivery of antiacne agents by enhancing their dermal localization with a concomitant reduction in their side effects. The current review emphasizes the potential of various novel drug delivery strategies like liposomes, niosomes, aspasomes, microsponges, microemulsions, hydrogels and solid lipid nanoparticles in optimizing and enhancing the topical delivery of antiacne agents.

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Topical Cyproterone Acetate Treatment in Women With Acne

Cited by 54 publications

References 22 publications

Clinical Evidence of the Endocrinological Influence of a Triphasic Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol in Treating Women with Acne vulgaris

Clinical Evidence of the Endocrinological Influence of a Triphasic Oral Contraceptive Containing Norgestimate and Ethinyl Estradiol in Treating Women with Acne vulgaris

The Response of Skin Disease to Stress

Novel Drug Delivery Systems: Potential in Improving Topical Delivery of Antiacne Agents

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