Innovative treatment using tilapia skin as a xenograft for partial thickness burns after a gunpowder explosion

Abstract

Tilapia skin has non-infectious microbiota, high amounts of type I collagen, and similar morphological structure to human skin, so it has been suggested as a potential xenograft for the management of burn wounds. A 23-year-old male patient, with no comorbidities, arrived at our burn treatment center after a thermal injury caused by contact with flames from a gunpowder explosion. Superficial partial thickness burns were present in his right upper limb and deep partial thickness burns were present in his left upper limb. Tilapia skin was applied to the lesions, leading to complete reepithelialization within 12 and 17 days of treatment, respectively. No dressing changes were needed and no side effects were observed. Tilapia skin carries the promise of an innovative, easy-to-apply and highly available product that can become the first nationally studied animal skin registered by the National Sanitary Surveillance Agency for use in the treatment of burns.

Evaluation of fish skin as a biological dressing for metacarpal wounds in donkeys

“…Nile tilapia fish skin has high collagen content more than in other skins [6,11]. Collagen is the biomaterial that is potential for wound repair [14][15][16].…”

“…Afifah et al [24] have reported that the wound healing process does not cause pain. Tilapia skin dressing has been exerted anti-nociceptive properties in other studies [10,11,17]. This may be attributed to the occlusive and adherent nature of the fish skin as a biological dressing [4,10].…”

“…Therefore, the fish skin dressed wounds had an increase in the number and size of newly formed blood vessels, indicating that the wound healing might be partially regulated through the blood vessels formation. Fish skin dressing is also rich in collagen and a number of amino acids, such as proline and alanine, which enhance the proliferation of fibroblasts, granulation tissue formation, and collagen synthesis in the wound [6,11,[38][39][40]. The fish skin dressed wounds had minimal collagen during the early stage of the wound healing because the wounds were recently inflamed and at the beginning of the proliferation.…”

Holistic Approach of Swiss Fetal Progenitor Cell Banking: Optimizing Safe and Sustainable Substrates for Regenerative Medicine and Biotechnology

“…Cell Therapies for Cutaneous Regenerative Medicine Sub-optimal pharmacotherapeutic management of severe and complex cutaneous affections and complications (e.g., chronic ulcers, burns, donor-site wounds) has prompted the development of numerous skin graft solutions (e.g., amniotic membrane, cadaver grafts, fish skin), innovative bioengineered cellular therapy solutions (e.g., cultured autografts), or autologous and allogenic cell-based products (e.g., Allox R , Apligraf R , Epicel R , Lyphoderm R , OrCel R , ReCell R , TransCyte TM ) that complement surgical care and support tissue structural integrity and functional recovery (Lukish et al, 2001;Limat and Hunziker, 2002;Kumar et al, 2004;Amani et al, 2006;Hartmann et al, 2007;Zaulyanov and Kirsner, 2007;Akita et al, 2008;Hirt-Burri et al, 2008b;Guerid et al, 2013;Zuliani et al, 2013;Malhotra and Jain, 2014;Tan et al, 2014;Debels et al, 2015;Akershoek et al, 2016;Abdel-Sayed et al, 2019b;Lima-Junior et al, 2019;Momeni et al, 2019;Climov et al, 2020). Further optimization of biological starting materials for such advanced solutions may primarily benefit FIGURE 5 | Differential overview highlighting the similarities and differences between stem cells and primary FPC types.…”

Neovaginoplasty for radiation-induced vaginal stenosis using Nile Tilapia Fish Skin as a biological graft

“…Nile Tilapia Fish Skin (NTFS) has non-infectious microbiota, morphological structure comparable to human skin, high in vivo bioresorption and wound healing activity in burns [5, 6]. When used as a biological graft for surgical management of Mayer–Rokitansky–Küster–Hauser syndrome (MRKHS), it led to good results [7].…”