Innovative Nanoporous Titania Surface with Stabilized Antimicrobial Ag-Nanoparticles via Salvadora persica L. Roots (Miswak) Extract for Dental Applications

Fadlallah, Sahar A.; El-Rab, Sanaa M. F. Gad; Halwani, Eman M.

doi:10.1007/s12668-020-00765-7

Cited by 3 publications

(2 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…AgNPs' antimicrobial activity has been reported and explained to have a synergistic effect with penicillin, boosting antibacterial efficiency by roughly 2-3 times, which is comparable with the findings of Gad El-Rab et al [39]. Furthermore, AgNPs show antibacterial effectiveness against multidrug-resistant infections, have simultaneous modes of action, and have a synergistic effect against pathogens such as S. aureus when paired with antibiotics [40]. Significant antibacterial effectiveness against tested bacteria was increased by increasing the concentration of AgNPs alone or in combination with penicillin.…”

Section: Discussionsupporting

confidence: 80%

“…[ 39 ]. Furthermore, AgNPs show antibacterial effectiveness against multidrug-resistant infections, have simultaneous modes of action, and have a synergistic effect against pathogens such as S. aureus when paired with antibiotics [ 40 ]. Significant antibacterial effectiveness against tested bacteria was increased by increasing the concentration of AgNPs alone or in combination with penicillin.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications

Abo‐Amer

El-Rab

Halawani

et al. 2022

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

Staphylococcus aureus causes diseases ranging from fairly minor skin and soft-tissue infections to dangerous sepsis [1,2]. All penicillins are ineffective against MRSA, including cephalosporins, carbapenems, semi-synthetic penicillinase-resistant congeners, and penems. Once methicillin was discovered in 1960, resistant strains were named after the showing of clinical isolates in England by 1967. MRSA was described in several countries primarily in the early 1980s. MDR-MRSA has been reported in numerous countries and is presently endemic in many hospitals worldwide, and commonly in developing countries such as Brazil [3].Because of the increased mortality related to MRSA infections, the emergence of strains resistant to methicillin and other antimicrobials has become a major concern, particularly in the hospital context [2]. Between 1999 and 2002, increases in methicillin resistance were found in S. aureus isolates in European nations, namely Belgium, Germany, Ireland, the Netherlands, and the United Kingdom. In Northern, Western, and Southern Europe, MRSA incidence ranged from 1% to 40%, respectively [4].The need to halt the spread of MRSA and decrease the incidence of MRSA infections in hospital settings now appears critical, as the multidrug-resistant organism's prevalence persists. According to a recent study, the average MRSA transporter ratio among healthcare workers is 4.6%, with 5.1% having typical MRSA infections. MRSA levels must also be controlled by healthcare staff [2].Staphylococcus aureus is a cause of high mortality in humans and therefore it is necessary to prevent its transmission and reduce infections. Our goals in this research were to investigate the frequency of methicillin-resistant S. aureus (MRSA) in Taif, Saudi Arabia, and assess the relationship between the phenotypic antimicrobial sensitivity patterns and the genes responsible for resistance. In addition, we examined the antimicrobial efficiency and application of silver nanoparticles (AgNPs) against MRSA isolates. Seventy-two nasal swabs were taken from patients; MRSA was cultivated on Mannitol Salt Agar supplemented with methicillin, and 16S rRNA sequencing was conducted in addition to morphological and biochemical identification. Specific resistance genes such as ermAC, aacA-aphD, tetKM, vatABC and mecA were PCR-amplified and resistance plasmids were also investigated. The MRSA incidence was ~49 % among the 72 S. aureus isolates and all MRSA strains were resistant to oxacillin, penicillin, and cefoxitin. However, vancomycin, linezolid, teicoplanin, mupirocin, and rifampicin were effective against 100% of MRSA strains. About 61% of MRSA strains exhibited multidrug resistance and were resistant to 3-12 antimicrobial medications (MDR). Methicillin resistance gene mecA was presented in all MDR-MRSA strains. Most MDR-MRSA contained a plasmid of > 10 kb. To overcome bacterial resistance, AgNPs were applied and displayed high antimicrobial activity and synergistic effect with penicillin. Our findings may help establish programs to control b...

show abstract

Section: Discussionsupporting

confidence: 80%

Section: Discussionmentioning

confidence: 99%

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications

Abo‐Amer

El-Rab

Halawani

et al. 2022

J. Microbiol. Biotechnol.

View full text Add to dashboard Cite

show abstract

Fabrication of Electrochemical Biosensor Based on Titanium Dioxide Nanotubes and Silver Nanoparticles for Heat Shock Protein 70 Detection

2021

View full text Add to dashboard Cite

This paper presents the fabrication methodology of an electrochemical biosensor for the detection of heat shock protein 70 (HSP70) as a potential tumor marker with high diagnostic sensitivity. The sensor substrate was a composite based on titanium dioxide nanotubes (TNTs) and silver nanoparticles (AgNPs) produced directly on TNTs by electrodeposition, to which anti-HSP70 antibodies were attached by covalent functionalization. This manuscript contains a detailed description of the production, modification, and the complete characteristics of the material used as a biosensor platform. As-formed TNTs, annealed TNTs, and the final sensor platform—AgNPs/TNTs, were tested using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and X-ray diffraction analysis (XRD). In addition, open circuit potential (OCP), electrochemical impedance spectroscopy (EIS), and cyclic voltammetry (CV) of these substrates were used to assess the influence of TNTs modification on their electrochemical characteristics. The EIS technique was used to monitor the functionalization steps of the AgNPs/TNTs electrode and the interaction between anti-HSP70 and HSP70. The produced composite was characterized by high purity, and electrical conductivity improved more than twice compared to unmodified TNTs. The linear detection range of HSP70 of the developed biosensor was in the concentration range from 0.1 to 100 ng/mL.

show abstract

Green Synthesis of Nanocomposites

Patil

Dhas

2022

Handbook of Research on Green Synthesis and Applications of Nanomaterials

View full text Add to dashboard Cite

Nanotechnology has been a dynamic research area over the past few decades because it assures the resolution to the problems that hamper progress. Currently, a new era of ‘green synthesis' is an emerging multidisciplinary field in nanotechnology which employs reliable, sustainable, low-cost, non-hazardous, and eco-friendly techniques. Green synthesis is considered a vital tool to reduce the negative impacts accompanying the traditional methods of synthesis for NPs commonly employed in industry and laboratory. This chapter unveils a comprehensive overview of the recent research on available green techniques for the synthesis of various nanocomposites in order to solve future generation challenges. This chapter also focuses on the green synthesis of various nanocomposites, synthesis parameters, potential applications, merits/demerits, and future prospects.

show abstract

Innovative Nanoporous Titania Surface with Stabilized Antimicrobial Ag-Nanoparticles via Salvadora persica L. Roots (Miswak) Extract for Dental Applications

Cited by 3 publications

References 50 publications

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications

Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcus aureus from Nasal Specimens: Overcoming MRSA with Silver Nanoparticles and Their Applications

Fabrication of Electrochemical Biosensor Based on Titanium Dioxide Nanotubes and Silver Nanoparticles for Heat Shock Protein 70 Detection

Green Synthesis of Nanocomposites

Contact Info

Product

Resources

About