Fabrication of Electrochemical Biosensor Based on Titanium Dioxide Nanotubes and Silver Nanoparticles for Heat Shock Protein 70 Detection

Nycz, Marta; Arkusz, Katarzyna; Pijanowska, Dorota G.

doi:10.3390/ma14133767

Cited by 25 publications

(18 citation statements)

References 93 publications

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“…Interleukin-6 (IL-6), a small inflammatory cytokine, has been a clinical trial target for MM, lymphoma, and other solid carcinomas. 105 Besides, it has been found that FR 106 and heat shock proteins 70 (HSP70) 107 are also overexpressed in MM. Aiming at these biological molecules, Lou et al 77 constructed a competitive electrochemical immunosensor for the detection of IL-6 based on ERGO-AuPdNPs-Ab 1 and AgNPs-Ab 2 probes.…”

Section: Applications Of Electrochemical Biosensors In Lymphoma and MMmentioning

confidence: 99%

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Sun

Huang

Wang

et al. 2022

Technol Cancer Res Treat

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Hematological malignancies encompass a wide variety of severe diseases that pose a serious threat to human health. Given the fact that hematological malignancies are difficult to treat due to their unpredictable and rapid deterioration and high rates of recurrence, growing attention has been paid to their early screening and diagnosis. However, developing a rapid and effective diagnostic tool featuring a noninvasive sampling technique is still extremely challenging. In recent years, novel nanomaterials-based electrochemical biosensors have attracted great interest because of such advantages as simple operation, low cost, fast response, etc. As a kind of rising nanomaterials, two-dimensional materials have excellent electronic and chemical properties, which have been proven to improve the performance of electrochemical biosensors. This review summarizes the applications of different types of electrochemical biosensors (nucleic acid sensors, immunosensors, aptamer biosensors, and cytosensors) based on two-dimensional materials in the detection of biological molecules related to hematological malignancies. Two-dimensional materials-based electrochemical biosensors designed for the diagnosis of leukemia could rapidly detect the target biomolecules at a trace level and show great merits such as wide linear range, low detection limit, high sensitivity, excellent selectivity, and cost-effectiveness. In addition, these biosensors have also achieved satisfactory results in the diagnosis of lymphoma and multiple myeloma. Thus, two-dimensional materials-based electrochemical biosensors are attractive for the early diagnosis of hematological malignancies in clinical practice. Nevertheless, more efforts are still required to further improve the performance of electrochemical biosensors. In this review, we propose the possible main concerns in the design of future two-dimensional materials-based electrochemical biosensors, involving the development of sensors for synchronous detection of diverse target biomolecules, the exploration of other superior two-dimensional materials, the simplification of the sensors fabrication process, the construction of new hybrid structures and how to avoid possible environmental issues.

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Section: Applications Of Electrochemical Biosensors In Lymphoma and MMmentioning

confidence: 99%

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Sun

Huang

Wang

et al. 2022

Technol Cancer Res Treat

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“…Similar to the AuNPs, AgNPs used in electrochemical (bio)sensors elaboration may improve the limit of detection of target molecules due to its high thermal, chemical stability, electrical conductivity, and catalytic activity [ 96 , 97 , 98 , 99 , 100 , 101 , 102 ]. Concerning other biomedical applications, AgNPs also presents a strong antimicrobial activity [ 103 , 104 ].…”

Section: Metal Nanoparticlesmentioning

confidence: 99%

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

et al. 2021

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Monitoring human health for early detection of disease conditions or health disorders is of major clinical importance for maintaining a healthy life. Sensors are small devices employed for qualitative and quantitative determination of various analytes by monitoring their properties using a certain transduction method. A “real-time” biosensor includes a biological recognition receptor (such as an antibody, enzyme, nucleic acid or whole cell) and a transducer to convert the biological binding event to a detectable signal, which is read out indicating both the presence and concentration of the analyte molecule. A wide range of specific analytes with biomedical significance at ultralow concentration can be sensitively detected. In nano(bio)sensors, nanoparticles (NPs) are incorporated into the (bio)sensor design by attachment to the suitably modified platforms. For this purpose, metal nanoparticles have many advantageous properties making them useful in the transducer component of the (bio)sensors. Gold, silver and platinum NPs have been the most popular ones, each form of these metallic NPs exhibiting special surface and interface features, which significantly improve the biocompatibility and transduction of the (bio)sensor compared to the same process in the absence of these NPs. This comprehensive review is focused on the main types of NPs used for electrochemical (bio)sensors design, especially screen-printed electrodes, with their specific medical application due to their improved analytical performances and miniaturized form. Other advantages such as supporting real-time decision and rapid manipulation are pointed out. A special attention is paid to carbon-based nanomaterials (especially carbon nanotubes and graphene), used by themselves or decorated with metal nanoparticles, with excellent features such as high surface area, excellent conductivity, effective catalytic properties and biocompatibility, which confer to these hybrid nanocomposites a wide biomedical applicability.

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“…In 2021, Nycz and coworkers prepared an electrochemical biosensor based on AgNPs and titanium urea dioxide nanotubes to determine heat shock protein 70 (HSP70) as a potential tumor marker. Titanium dioxide (TiO 2 ) exhibits outstanding properties such as biocompatibility, large surface area, high stability, and good electrical conductivity [98]. Usage of TiO 2 nanotubes with AgNPs increased the electrical conductivity of the sensor system, thereby improving its analytical performance.…”

Section: Metal Np-based Sensorsmentioning

confidence: 99%

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

Laraib

Arshad

et al. 2021

Nanomaterials

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Over various scientific fields in biochemistry, amino acids have been highlighted in research works. Protein, peptide- and amino acid-based drug delivery systems have proficiently transformed nanotechnology via immense flexibility in their features for attaching various drug molecules and biodegradable polymers. In this regard, novel nanostructures including carbon nanotubes, electrospun carbon nanofibers, gold nanoislands, and metal-based nanoparticles have been introduced as nanosensors for accurate detection of these organic compounds. These nanostructures can bind the biological receptor to the sensor surface and increase the surface area of the working electrode, significantly enhancing the biosensor performance. Interestingly, protein-based nanocarriers have also emerged as useful drug and gene delivery platforms. This is important since, despite recent advancements, there are still biological barriers and other obstacles limiting gene and drug delivery efficacy. Currently available strategies for gene therapy are not cost-effective, and they do not deliver the genetic cargo effectively to target sites. With rapid advancements in nanotechnology, novel gene delivery systems are introduced as nonviral vectors such as protein, peptide, and amino acid-based nanostructures. These nano-based delivery platforms can be tailored into functional transformation using proteins and peptides ligands based nanocarriers, usually overexpressed in the specified diseases. The purpose of this review is to shed light on traditional and nanotechnology-based methods to detect amino acids, peptides, and proteins. Furthermore, new insights into the potential of amino protein-based nanoassemblies for targeted drug delivery or gene transfer are presented.

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Fabrication of Electrochemical Biosensor Based on Titanium Dioxide Nanotubes and Silver Nanoparticles for Heat Shock Protein 70 Detection

Cited by 25 publications

References 93 publications

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Applications of electrochemical biosensors based on 2D materials and their hybrid composites in hematological malignancies diagnosis

Metal Nanoparticles and Carbon-Based Nanomaterials for Improved Performances of Electrochemical (Bio)Sensors with Biomedical Applications

Amino Acids, Peptides, and Proteins: Implications for Nanotechnological Applications in Biosensing and Drug/Gene Delivery

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