Innovation Technologies for Human Microbiome Improvement

Yankovsky, D.S.; Широбоков, В. П.; Дымент, Г. С.

doi:10.15407/scine14.06.011

Cited by 4 publications

(8 citation statements)

References 5 publications

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“…За щільністю мікробного заселення організму людини ротова порожнина займає друге місце, поступаючись лише товстому кишківнику [15]. Сьогодні встановлено, що мікробіом ротової порожнини представлений більш як 500 видами мікроорганізмів, які є представниками як мінімум 16 родів, при чому значна частина яких не здатна культивуватись in vitro відомими методами [16].…”

Section: мікробіом ротової порожнини та його зміни при використанні б...unclassified

“…На думку вчених, така специфічність може використовуватись навіть для ідентифікації макроорганізму за прикладом відбитків пальців [17]. Крім мікроорганізмів бактеріальної природи, в ротовій порожнині в нормі можуть виявлятись археї, віруси (бактеріофаги), гриби та деякі найпростіші [15].…”

Section: мікробіом ротової порожнини та його зміни при використанні б...unclassified

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Мікробіом Ротової Порожнини Та Його Зміни При Використанні Брекет-Систем

Кисіль,

Шилов,

Жемера

2023

Перспективи та інновації науки

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Section: мікробіом ротової порожнини та його зміни при використанні б...unclassified

Мікробіом Ротової Порожнини Та Його Зміни При Використанні Брекет-Систем

Кисіль,

Шилов,

Жемера

2023

Перспективи та інновації науки

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“…Водночас дослідження таксономії мікробного розмаїття різних органів і систем показали, що найбільша кількість мікроорганізмів сконцентрована в травному тракті (у ротоглотці, шлунку та кишечнику міститься до 75% мікробних популяцій людини), сечостатевих шляхах чоловіків (2-3%), жінок (9-12%). Близько 13-23% мікробіоти колонізує усі інші біотопи [35,41].…”

Section: результати обговоренняunclassified

The human microbiome and modern approaches to its preservation (analytical review)

Bobyr,

Nazarchuk,

Paliy

et al. 2023

Rep. of Vinnytsia Nation. Med. Univ.

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Annotation. The article is devoted to the analysis of modern data on the diversity of the microbiome of the human body and the characteristics of the latest trends for its preservation. Scientific search engines, databases of electronic resources PubMed, IRBIS, and Google Scholar were used for information analysis using bibliosemantic, system review methods. The results of research by Ukrainian and foreign scientists indicate a huge positive influence of the microbiome of the human body on physiological and biochemical processes. Specialists in biology and medicine differentiate the microbiome as an “organ”- system that participates in the processes of digestion and metabolism, provides protective functions of mucous membranes, and supports the immune system in working order. The analytical review presents modern data on the formation of the human microbiome as a result of the joint long-term evolution of the human body with microorganisms that inhabited its biotopes. References from scientific sources on the study of the localization of the microbiome and the interaction of microorganisms of different biotopes to maintain homeostasis are discussed in the work. Modern scientific data provide examples of microbiome disturbances in the etiology of human diseases. In particular, changes in the microbiome correlate with the occurrence of gastrointestinal and systemic diseases. Discussions continue among scientists about the causes of dysbiosis and ways to correct it. An analysis of the results of research on the feasibility of using certain means of improving the microbiome with the help of probiotics and intestinal microbiota transplantation was carried out. The article presents the latest classification of probiotic preparations, requirements for modern means of dysbiosis correction, and approaches to the creation of immobilized probiotics.

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“…Particularly dangerous in this regard is the use of antibiotics for prophylactic purposes. However, some other groups of drugs can contribute to the formation of dysbiosis by affecting the kinetics of the epithelium of mucous membranes and, accordingly, the composition of mucin (nonsteroidal anti-inflammatory drugs, laxatives, cholagogues, enveloping agents with sorbent properties and some others) [23,25].…”

Section: Introductionmentioning

confidence: 99%

The role of sorbents and probiotics in prevention of structural and morphological disorders in the small intestine of animals developing in dysbiosis

et al. 2020

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The past decade is characterized by a noticeable increase in the interest of physicians in all areas of activity in the development of new and improvement of existing approaches to the correction of dysbiotic disorders. Among them, the concept of using probiotics occupies a leading position. At the same time, some enterosorbents, the mechanism of action of which is largely due to the sanitation of the intestinal lumen and due to this improvement of conditions for the vital activity of the physiological microbiota, can be attributed to the group of means of improving the normal microflora. In the context of an increase in the level of resistance to antibacterial agents, the inclusion of enterosorbents in the complex therapy of dysbiosis is an important and pathogenetically justified approach. The aim of the work was to clarify the effectiveness of the use of sorbents and probiotics for the prevention of structural and morphological disorders in the small intestine of white mice developing against the background of antibiotic-induced dysbiosis. Electron-microscopic methods showed that in the mucous membrane of the small intestine of mice after using the probiotic “Simbiter” the extinction of manifestations of cytodestructive disorders is observed. In addition, the obtained electron microscopic data, indicating the ability of probiotic drugs with the simultaneous introduction into the body of animals with a complex of antibiotics, to stimulate the body’s immune response. As a result of ultrastructural analysis of the mucous membrane of the small intestine of mice, the formation of dysbiosis in which occurred against the background of the use of enterosorbents, a decrease in the severity of structural damage was found, compared with the group of animals that received only antibiotics. After using “Symbiogel”, activation of plasma cells was registered, which can be an indicator of the inflammatory process and the activity of the immune response in general, as evidenced by the detection of plasma cells with dilated tubules. In general, it should be noted that the use of “Symbiogel” for the prevention of dysbiotic disorders contributes to the formation of a more pronounced immune response, compared with probiotic drugs. So, on the model of antibiotic-induced dysbiosis at the ultrastructural level, the ability of multiprobiotics “Simbiter®” and sorbent “Symbiogel” to reduce cytodestructive changes in the mucous membrane of the small intestine of mice and normalize morphoimunogenesis was proved.

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Innovation Technologies for Human Microbiome Improvement

Cited by 4 publications

References 5 publications

Мікробіом Ротової Порожнини Та Його Зміни При Використанні Брекет-Систем

Мікробіом Ротової Порожнини Та Його Зміни При Використанні Брекет-Систем

The human microbiome and modern approaches to its preservation (analytical review)

The role of sorbents and probiotics in prevention of structural and morphological disorders in the small intestine of animals developing in dysbiosis

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