The role of sorbents and probiotics in prevention of structural and morphological disorders in the small intestine of animals developing in dysbiosis

Abstract

The past decade is characterized by a noticeable increase in the interest of physicians in all areas of activity in the development of new and improvement of existing approaches to the correction of dysbiotic disorders. Among them, the concept of using probiotics occupies a leading position. At the same time, some enterosorbents, the mechanism of action of which is largely due to the sanitation of the intestinal lumen and due to this improvement of conditions for the vital activity of the physiological microbiota, can be attributed to the group of means of improving the normal microflora. In the context of an increase in the level of resistance to antibacterial agents, the inclusion of enterosorbents in the complex therapy of dysbiosis is an important and pathogenetically justified approach. The aim of the work was to clarify the effectiveness of the use of sorbents and probiotics for the prevention of structural and morphological disorders in the small intestine of white mice developing against the background of antibiotic-induced dysbiosis. Electron-microscopic methods showed that in the mucous membrane of the small intestine of mice after using the probiotic “Simbiter” the extinction of manifestations of cytodestructive disorders is observed. In addition, the obtained electron microscopic data, indicating the ability of probiotic drugs with the simultaneous introduction into the body of animals with a complex of antibiotics, to stimulate the body’s immune response. As a result of ultrastructural analysis of the mucous membrane of the small intestine of mice, the formation of dysbiosis in which occurred against the background of the use of enterosorbents, a decrease in the severity of structural damage was found, compared with the group of animals that received only antibiotics. After using “Symbiogel”, activation of plasma cells was registered, which can be an indicator of the inflammatory process and the activity of the immune response in general, as evidenced by the detection of plasma cells with dilated tubules. In general, it should be noted that the use of “Symbiogel” for the prevention of dysbiotic disorders contributes to the formation of a more pronounced immune response, compared with probiotic drugs. So, on the model of antibiotic-induced dysbiosis at the ultrastructural level, the ability of multiprobiotics “Simbiter®” and sorbent “Symbiogel” to reduce cytodestructive changes in the mucous membrane of the small intestine of mice and normalize morphoimunogenesis was proved.

Enterosorbents in complex therapy of food allergies: a focus on digestive disorders and systemic toxicity in children

“…Experience with this type of treatment, mainly in post-Soviet countries, has shown the feasibility of its use in the acute period of allergic diseases and to prevent recurrence of the disease. Today, enterosorption is a component of complex therapy for various types of intoxication, including allergic, with a scientifically based and clinically proven efficacy (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(111)(112)(113)(114)(115)(116)(117)(118)(119)(120)(121)(122)(123)(124)(125).…”

“…The clinical efficacy of some enterosorbents in mild and moderate forms of intestinal infections is not inferior to antibiotics (32). Effectiveness of enterosorption is comparable to the use of probiotics (120,121).…”

“…At the same time, the daily dose of enterosorbents is evenly distributed into 3-4 doses between breakfast, lunch, and dinner. The course of treatment is 6-8 days (no more than 14 days) with a gradual dose reduction over the last 2-3 days (23-30, 113,115,119,120,123).…”