Innervation of papilla vallata in diabetic rats

Hevér, Helén; Altdorfer, Károly; Zelles, T; Batbayar, Bayarchimeg; Fehér, Erzsébet

doi:10.1556/oh.2013.29570

Cited by 4 publications

(3 citation statements)

References 32 publications

(37 reference statements)

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“…Our findings highlighted marked alterations in the taste buds of diabetic rats (Figure 2). There was a noticeable reduction in the cellular content of taste buds in these rats, echoing outcomes from earlier studies [11,16]. Intriguingly, these alterations were more pronounced in the STZ-induced diabetic rats that did not receive 4-HR treatment compared to those that did, indicating that 4-HR plays a protective role against the taste disturbances seen in diabetes.…”

Section: Discussionsupporting

confidence: 82%

“…Although research has delved into apoptosis's role in taste biology, especially concerning age-related taste deterioration [1], the connection between apoptosis and taste dysfunctions in DM has not been extensively explored. Some initial research on diabetic rat models points to changes in the structure of vallate taste buds but stops short of probing into apoptosis [11,16].…”

Section: Introductionmentioning

confidence: 99%

“…The existing literature provides a wealth of information regarding the effects of DM on taste perception [11,16] and the medicinal attributes of 4-HR [19,20], largely derived from studies conducted on animal models. While these studies offer invaluable insights, they also highlight a notable limitation-the potential disparity between the responses observed in animal models and humans.…”

Section: Introductionmentioning

confidence: 99%

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4-Hexylresorcinol and Its Effects on Circumvallate Papillae Taste Buds in Diabetic and Healthy Rats: An Initial Investigation

Gaida,

Park,

Kim

2023

Applied Sciences

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Taste perception plays a crucial role in health and well-being but can be compromised by conditions such as diabetes mellitus (DM). This study delved into the efficacy of 4-hexylresorcinol (4-HR) in mitigating taste bud apoptosis, particularly in relation to DM-induced taste issues. Two primary rat groups were investigated: healthy rats and streptozotocin (STZ)-induced diabetic rats. Each group was further divided into control and experimental subsets, with the experimental group receiving 4-HR injections. A histological analysis of the circumvallate papillae (CVP) highlighted significant taste bud deterioration in the STZ subgroup, including loss of cellular content and a deviation from their typical morphology. Quantitatively, the control group had a mean of 39.6 ± 14.3 taste bud pores/mm2, contrasting with the 4HR, STZ, and STZ/4HR groups, which had means of 33.7 ± 14.2, 20.3 ± 6.1, and 28.0 ± 8.3, respectively. Additionally, a TUNEL assay and IHC staining for c-caspase-3 both identified increased apoptotic cells in the STZ subgroup, with the mean number of apoptotic cells per taste bud profile being notably higher in the STZ group at 3.2 ± 1.6. This study underscores the profound impact of diabetes on taste bud physiology and the potential therapeutic benefits of 4-HR. Further research is essential to delve deeper into its mechanisms and to ascertain optimal dosages, with the aim of enhancing the quality of life of diabetic patients.

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Section: Discussionsupporting

confidence: 82%