Characteristics of lingual papillae in diabetic rats

Mechanism underlying the anti-diabetic potential of bee venom as compared to bone marrow mesenchymal stem cells in the diabetic rat tongue

“…The effect of uncontrolled DM on rats' tongue epithelium and papillae has been previously reported. Streptozotocin-induced DM in rats has been associated with alterations in the distribution and morphology of the fungiform and filiform papillae, with areas of epithelial desquamation, [29][30][31] in addition to a significant reduction in the height and width of the filiform papillae. 32 Diabetes mellitus has also been associated with the atrophy and a decreased thickness of dorsal surface epithelium, [32][33][34] and the atrophy of ventral surface epithelium.…”

Periodontal Destruction and Regeneration in Experimental Models: Combined Research Approaches

“…It was observed, that in the diabetes group the epithelial thickness was greater, compared to the control group, and the congestion of the gingival capillaries, which showed that blood circulation was impaired in diabetes cases [2]. Characteristic morphological observations on the lingual mucosa of the streptozotocin treated rats were atrophic changes of lingual mucosa and the median rhomboid glossitis [3]. In rats with streptozotocininduced diabetes mellitus, local administration of tiludronic acid, antiresorptive and anti-inflammatory properties have not been evaluated in the periodontitis-diabetes mellitus association yet, and promoted a protective effect against tissue destruction [21].…”

“…Epidemiologic and clinical studies have indicated, that a risk factor for periodontal disease progression is diabetes mellitus as a metabolic disorder, resulting with many different complications, including soft tissue abnormalities in the oral cavity such as periodontitis and salivary and taste dysfunction [2,3]. Zheng B. et al (2017) noted that osteoporosis is associated with widespread periodontitis and impaired periodontal healing.…”

“…Material and methods. The rat models, used in the reviewed publications were: ligature-induced [5,13,[15][16][17][18][19], streptozotocin-induced [2,3,20,21] and immune complexes-induced [22] experimental periodontitis; 3-wall periodontal defect in Wistar rats [9,14],osteoporotic rats periodontal fenestration defect model [4], apical periodontitis, induced in Wistar rats by pulp exposure to oral cavity [23], altered functional loading model with use of a hard and soft diet and the posterior bite-blocks in rats [24], as well as rats stress exposures in different modes [25], experimental rat model of surgically created chronic acid reflux esophagitis [26]. The combined bilayered compartmentalized system was used to promote the regeneration of alveolar bone in Wistar rats [14].…”

“…The results obtained were the subject of histomorphomorphological/-metrical [10, 13, 14, 17, 19, 20, 21-25, 27-29, 30], immunohisto (-cyto)chemical [15,16,10,20,7,28,21,29,6,30,5,19] and histopathological [2,4,5,9,31,22] analysis, micro-computed tomography [9,15,16,18,19,21,24,28]. The laboratory methods involved were real-time quantitative reverse-transcription polymerase chain reaction [11,15,16,21] enzyme-linked immunosorbent assay [16,17], scanning [3], and transmission electron microscopy [32], polarizing light microscopy [29], confocal microscopy and spectrophotometry [15], radiographic and biomechanical analysis [18], descriptive histology and computer-assisted image analysis [12].…”