Inkjet‐Printed Planar Biochips for Interfacial Detection of Biomoleculars

Diao, Jianglin; Ding, Ailing; Liu, Yuqing; Razal, Joselito M.; Lu, Zhisong; Wang, Bin

doi:10.1002/admi.201700588

Cited by 4 publications

(4 citation statements)

References 22 publications

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“…Protein microarrays have become a powerful tool in biorelated fields such as precision diagnostics, biomarker screening, drug screening, and proteomics due to the advantages of high throughput, miniaturization, fast quantification, convenient handling, and reduced amount of analyte. − Inorganic materials such as glass and silicon wafer have been widely used as a substrate for the fabrication of biochips because of their excellent bulk properties and surface reactiveness for further modification. , Compared with inorganic support, polymer substrates show good processability and are lightweight and impact resistant; thus, they are conducive to large-scale industrial production of low-cost disposable biochips. Recently, many polymer substrate such as poly(methyl methacrylate) (PMMA), , polystyrene (PS), , polycarbonate (PC), , poly(ethylene terephthalate) (PET), polydimethylsiloxane (PDMS), , and cyclic olefin copolymer (COC) , have been investigated as substrates for biochip preparation.…”

Section: Introductionmentioning

confidence: 99%

Facile Surface Functionalization of Cyclic Olefin Copolymer Film with Anhydride Groups for Protein Microarray Fabrication

Yuan

Wang

Chen

et al. 2020

ACS Appl. Bio Mater.

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Immobilization of protein at high efficiency is a challenge for fabricating polymer-based protein chips. Here, a simple but effective approach was developed to fabricate a cyclic olefin copolymer (COC)-based protein microarray with a high immobilization density. In this strategy, poly(maleic anhydride-co-vinyl acetate) (poly(MAH-co-VAc)) brushes were facilely attached on the COC surface via UV-induced graft copolymerization. The introduction of poly(MAH-co-VAc) brushes resulted in an obvious increase in the surface roughness of COC. The functionalized COC showed little reduction in transparency compared with pristine COC, indicating that the photografting treatment did not alter its optical property. The graft density of the anhydride groups on the modified COC could be tuned from 0.46 to 3.2 μmol/cm2. The immobilization efficiency of immunoglobulin G (IgG) on functionalized COC reached 88% due to the high reactivity between anhydride groups and amine groups of IgGs. An immunoassay experiment demonstrated that the microarray showed high sensitivity to the target analyte.

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Section: Introductionmentioning

confidence: 99%

Facile Surface Functionalization of Cyclic Olefin Copolymer Film with Anhydride Groups for Protein Microarray Fabrication

Yuan

Wang

Chen

et al. 2020

ACS Appl. Bio Mater.

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“…As a consequence, there are several strategies to enhance the obtained signal for the selective detection of DNA, including the use of nanomaterial assemblies [31], the addition of nanotags, such as silver nanoparticles, to the DNA duplex [32], nuclease-assisted target recycling [33], polymerase-based target recycling amplification [34], and isothermal solid-phase amplification [35]. Gold and silver [37] Amperometry n/a H 2 O 2 Paper Graphene [38] Square-wave voltammetry…”

Section: Biosensormentioning

confidence: 99%

Inkjet Printing for Biosensors and Bioelectronics

Adly

Rinklin

2019

Organic Bioelectronics for Life Science and Healthcare

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This chapter examines the role of inkjet printing for the fabrication of biosensors and bioelectronic devices. Inkjet printing is a promising technique that can be employed to directly fabricate sensors and electronics on a variety of substrates including flexible plastics and soft silicones. In contrast to state-of-the-art mask-based microfabrication it is capable of testing new materials and designs in a rapid prototyping approach. As such, it has the potential to play a powerful role in the development of customized devices. Here, we present an overview of recent research describing the application of inkjet technologies to print functional biosensors and bioelectronic devices. We discuss advantages and limitations of this approach and address possible routes to overcome current challenges for future developments in this field.

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“…Inkjet printing technique is a facile, noncontact approach, which has been used to deposit picoliter volumes of materials in a drop‐on‐demand manner. This method could greatly reduce the consumption of materials and print on a wide‐variety of substrates including papers, glasses, polymers, and fabrics . More importantly, inkjet printing technique allows the end users to precisely deposit inks on substrates according to their designs.…”

Section: Introductionmentioning

confidence: 99%

Flexible Supercapacitor Based on Inkjet‐Printed Graphene@Polyaniline Nanocomposites with Ultrahigh Capacitance

Diao

Jia

Ding

et al. 2018

Macro Materials & Eng

Self Cite

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This work describes the fabrication of high‐performance all‐solid‐state supercapacitors based on covalently‐anchored reduced graphene oxide (RGO)@polyaniline (PANI) composites via an inkjet printing method. Morphological and chemical characterization data show that PANI nanoparticles are immobilized on graphene oxide (GO) nanosheets via covalent bonds. Sandwich‐structured and interdigitated supercapacitors are fabricated by printing the as‐prepared GO@PANI composites on flexible substrates, followed by a chemical reduction. The devices display high volumetric capacitances (258.5 F cm−3 at 1 mV s−1 for sandwich‐structured ones and 554 F cm−3 at 1 mV s−1 for interdigitated ones) and excellent cycling retention (2000 cycles >90%). Moreover, at the bending state, there are no significant changes on the device capacitances, indicating their great flexibility. The high‐performance devices can be further designed to produce special geometries and patterns. The work may provide a novel strategy to fabricate RGO@PANI composite‐based supercapacitors, which allows the end users to precisely deposit active materials according to their designs, for miniature and wearable electronics.

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Inkjet‐Printed Planar Biochips for Interfacial Detection of Biomoleculars

Cited by 4 publications

References 22 publications

Facile Surface Functionalization of Cyclic Olefin Copolymer Film with Anhydride Groups for Protein Microarray Fabrication

Facile Surface Functionalization of Cyclic Olefin Copolymer Film with Anhydride Groups for Protein Microarray Fabrication

Inkjet Printing for Biosensors and Bioelectronics

Flexible Supercapacitor Based on Inkjet‐Printed Graphene@Polyaniline Nanocomposites with Ultrahigh Capacitance

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