Injectable zein gel with in situ self-assembly as hemostatic material

Raza, Ali; Zhang, Yubei; Hayat, Uzma; Liu, Chang; Song, Jie-Liang; Shen, Naian; Yin, Chao; Wang, Huajie; Wang, Jin‐Ye

doi:10.1016/j.bioadv.2022.213225

Cited by 8 publications

(8 citation statements)

References 52 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3 Particularly, a zein-based hemostatic gel has recently been developed for hemostasis under coagulopathy conditions, owing to the high adhesion of released zein with platelets. 31 Considering such favorable affinity with RBCs/platelets regardless of plasma proteins, P 65 would be of great potential for achieving effective hemostasis under coagulopathy conditions. Preparation and Characterization of the Janus Sponge.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

“…Owing to the key role of plasma proteins on the blood coagulation system, there exists a series of coagulopathy conditions arisen by the coagulation factor deficiency (e.g., FXIII) and coagulation factor-related medications (e.g., heparin and clopidogrel) . Particularly, a zein-based hemostatic gel has recently been developed for hemostasis under coagulopathy conditions, owing to the high adhesion of released zein with platelets . Considering such favorable affinity with RBCs/platelets regardless of plasma proteins, P 65 would be of great potential for achieving effective hemostasis under coagulopathy conditions.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis

Wang,

Lin,

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Apart from the wide and safe application of natural polymerbased hemostatic materials/devices, it is still desirable to develop new types of hemostatic materials that can achieve both potent coagulopathic hemostasis and a facile preparation process. In this work, one Janus gelatin sponge (J-ZGS) is readily constructed for both coagulation-dependent and coagulopathic hemostasis by embedding zein nanoparticles on the surface of a self-prepared gelatin sponge (S-GS): zein nanoparticles were facilely prepared by an antisolvent method to achieve procoagulant blood−material interactions, while S-GS was prepared by freeze-drying a foaming gelatin solution. Due to the distinct secondary structure, the optimal zein nanoparticles possessed a higher in vitro hemostatic property than the pristine zein powder and other nanoparticles, the underlying mechanism of which was revealed as the superior RBC/platelet adhesion property in the presence/absence of plasma proteins. Compared with S-GS and a commercial gelatin sponge, J-ZGS achieved a significantly higher in vitro hemostatic property and similarly good blood compatibility/cytocompatibility. Moreover, in vivo artery-injury models confirmed the outstanding hemostatic performance of J-ZGS under both coagulation-dependent and coagulopathic conditions. Our work offers an appealing approach for developing potent hemostatic sponges from natural polymer-based nanoparticles that could be further extended to versatile hemostatic materials for coagulopathic hemostasis.

show abstract

Section: ■ Results and Discussionmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis

Wang,

Lin,

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

show abstract

“…18,19 Injectable hemostatic materials (IHMs), as a new type of hemostatic material, have the advantages of good hemostatic effect, antimicrobial properties, and biodegradability, which have attracted widespread attention and interest. [20][21][22][23][24][25][26][27][28][29] The research and development of IHMs have become a current hotspot and challenge. 30 Currently, the research related to IHMs provides good inspiration for the treatment of uncontrollable traumatic bleeding.…”

Section: Introductionmentioning

confidence: 99%

State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding

Feng,

Yang

2024

International Wound Journal

View full text Add to dashboard Cite

Traumatic haemorrhage is a prevalent clinical condition, and effective and timely haemostasis is crucial for the preservation of patients' lives. In recent years, injectable hemostatic materials have gained significant attention due to their excellent hemostatic efficacy, biocompatibility, and biodegradability, making them widely applied in the treatment of incompressible traumatic haemorrhage. Systematic analysis of injectable hemostatic materials is crucial for research in this area. This article provides a comprehensive review of the development and research trends of injectable hemostatic materials over the past 20 years using visualization techniques. Analysis of collaboration and co‐citation networks revealed localized research collaboration networks, highlighting the need for enhanced international collaboration in the field of injectable hemostatic materials. Current research focuses primarily on hemostatic materials, hemostatic processes, and hemostatic mechanisms. Injectable hemostatic materials with excellent performance offer promising strategies for wound healing. This review provides a comprehensive and systematic summary of injectable hemostatic materials, offering valuable guidance for the development and clinical application of novel injectable hemostatic materials. Additionally, visualized methodology and mapping analysis are effective data mining methods that provide approaches and strategies for clear knowledge network analysis. These methods facilitate better understanding and interpretation of research dynamics in the field of injectable hemostatic materials, thereby guiding and inspiring future research.

show abstract

“…Gel-based adhesives are widely used in biomedicine because they are shape-invariant fluids and have the ability to mimic the natural extracellular matrix, and their own wet and soft properties can be applied to deep irregularities and wounds that are not easily sutured . The existing hemostatic materials are mainly composed of the following categories, gauze, bandage, sponge, particle powder, and gel binder. , Among the above hemostatic materials, only particle powder and gel adhesive have no limitations in the use of wound types and have a wide range of applications. , Gauze, bandages, or sponges can only be applied to surface wounds or temporary hemostasis of wounds due to the shape of the hemostatic material, but they are ineffective for deep or incompressible wounds that are difficult to suture. , …”

Section: Introductionmentioning

confidence: 99%

“…4,5 Among the above hemostatic materials, only particle powder and gel adhesive have no limitations in the use of wound types and have a wide range of applications. 6,7 Gauze, bandages, or sponges can only be applied to surface wounds or temporary hemostasis of wounds due to the shape of the hemostatic material, but they are ineffective for deep or incompressible wounds that are difficult to suture. 8,9 In the treatment of massive bleeding wounds, by only using powder hemostatic materials, the materials are easy to be washed away and cannot play a better role in hemostasis.…”

Section: Introductionmentioning

confidence: 99%

Preparation and Hemostatic Effect of Micro-Nanograded Porous Particles Doped with Dopamine-Based Water-Triggered Intelligent Composite Adhesives

Zheng

Gao

Quan

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

The wet environment of water or tissue in bleeding wounds poses significant challenges to the adhesion performance of existing hemostatic adhesives. An intelligent composite adhesive prepared by doping starch-based silicate micro-nanograded porous particles (MBC@CMS) with dopamine-hyperbranched polymers (HPD, 7800 M w ) synthesized by the Michael addition reaction could be triggered by water to form a glue (MBC@CMS-HPD). The results indicated that MBC@CMS-HPD could still have adhesion properties under running water washing and water immersion and could effectively seal the water outlet. The results of the glue-forming mechanism showed that MBC@CMS-HPD had better wettability than water, which could eliminate water molecules at the wet adhesive surface. When contacted with water, the agglomeration of the HPD hydrophobic chain increases the exposure of the catechol group, and the relative atomic mass of the N element on the surface increases from 2.8 to 4.8%. The adhesion of MBC@CMS-HPD was enhanced and stable. MBC@ CMS-HPD showed significant hemostasis effects in five injury bleeding models of Sprague−Dawley (SD) rats and New Zealand rabbits. Especially in the fatal femoral artery bleeding model of New Zealand rabbits, MBC@CMS-HPD reduced the amount of bleeding by 75% and shortened the bleeding time by 78% compared with the a-cyanoacrylate adhesives. The results of the coagulation mechanism showed that compared with HPD, MBC@CMS-HPD could activate both endogenous and exogenous coagulation pathways. Among them, after contact with blood, HPD formed a gel to close the blood outlet, and MBC@CMS entered the wound to activate the internal and external coagulation pathways. In addition, HPD and MBC@CMS had good histocompatibility and degradability, which has the potential to be applied to different wounds.

show abstract

Injectable zein gel with in situ self-assembly as hemostatic material

Cited by 8 publications

References 52 publications

A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis

A Janus Gelatin Sponge with a Procoagulant Nanoparticle-Embedded Surface for Coagulopathic Hemostasis

State of the art, trends, hotspots, and prospects of injection materials for controlling bleeding

Preparation and Hemostatic Effect of Micro-Nanograded Porous Particles Doped with Dopamine-Based Water-Triggered Intelligent Composite Adhesives

Contact Info

Product

Resources

About