Injectable wireless microdevices: challenges and opportunities

Khalifa, Adam; Lee, Sunwoo; Molnar, Alyosha; Cash, Sydney S.

doi:10.1186/s42234-021-00080-w

Cited by 17 publications

(17 citation statements)

References 46 publications

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“…Advances in complementary metal-oxide-semiconductor (CMOS) technology have in fact permitted over the past few years the design and fabrication of low-area, low-power, and highly integrated solutions optimized for untethered sensing of biological parameters. Notably, a number of fully injectable wireless micro-devices have already been successfully validated in animal models for monitoring biological parameters such as temperature, glucose, and even the spiking activity from a mouse brain (see Khalifa et al, 2021 ), thus supporting the feasibility of the model proposed in this work. Table 1 reports a comparison of the most relevant systems proposed in the literature.…”

Section: Introductionsupporting

confidence: 55%

Integrated Micro-Devices for a Lab-in-Organoid Technology Platform: Current Status and Future Perspectives

et al. 2022

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Advancements in stem cell technology together with an improved understanding of in vitro organogenesis have enabled new routes that exploit cell-autonomous self-organization responses of adult stem cells (ASCs) and homogenous pluripotent stem cells (PSCs) to grow complex, three-dimensional (3D), mini-organ like structures on demand, the so-called organoids. Conventional optical and electrical neurophysiological techniques to acquire functional data from brain organoids, however, are not adequate for chronic recordings of neural activity from these model systems, and are not ideal approaches for throughput screenings applied to drug discovery. To overcome these issues, new emerging approaches aim at fusing sensing mechanisms and/or actuating artificial devices within organoids. Here we introduce and develop the concept of the Lab-in-Organoid (LIO) technology for in-tissue sensing and actuation within 3D cell aggregates. This challenging technology grounds on the self-aggregation of brain cells and on integrated bioelectronic micro-scale devices to provide an advanced tool for generating 3D biological brain models with in-tissue artificial functionalities adapted for routine, label-free functional measurements and for assay’s development. We complete previously reported results on the implementation of the integrated self-standing wireless silicon micro-devices with experiments aiming at investigating the impact on neuronal spheroids of sinusoidal electro-magnetic fields as those required for wireless power and data transmission. Finally, we discuss the technology headway and future perspectives.

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Section: Introductionsupporting

confidence: 55%

Integrated Micro-Devices for a Lab-in-Organoid Technology Platform: Current Status and Future Perspectives

et al. 2022

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“…Since TPC is capable of guaranteeing EV charging requirements, it can greatly reduce the converter volume as well as the weight of required copper and insulation material for the EV plug. In addition to charging applications, near/mid-field TPC can be also used for powering medical implants, in particular using magnetic resonant coupling [82], [83]. Battery-free wearable sensors have been enabled by this technology where data and power can be exchanged between sensors easily in near-field [84].…”

Section: B Prospective Applications Of Tpcmentioning

confidence: 99%

Overview of Talkative Power Conversion Technologies

Liserre

Beiranvand

Leng

et al. 2023

IEEE Open J. Power Electron.

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Power Line Communication (PLC) and Simultaneous Wireless Information and Power Transfer (SWIPT) are popular examples of applications, where power and information are transmitted simultaneously. In most cases, different devices have been used to generate the power and communication signals independently. Usually, the information is superimposed onto the power signal using an external modulator. Recently, power converters have been used to generate pulses not just for power conversion but also for information transfer simultaneously. This approach represents a fundamental difference because it exploits the signal processing potential of Pulse Width Modulation (PWM), where for power conversion only the average pulse width is used, while the information is represented by the harmonics instead of being filtered out, as typically done in power electronics. The concept of embedding information into the switching ripple generated by a switched-mode power converter has recently been dubbed Talkative Power (TP), in this paper referred as Talkative Power Conversion (TPC). TPC technologies are reviewed in non-isolated and isolated converters in this paper. Potential applications include visible light communications, battery management systems, switching reluctance generators/motors, microgrids, and wireless electric vehicle charging stations. Finally, trending topics are identified.INDEX TERMS Talkative power conversion, pulse width modulation converters, power line communication, switching ripple communication, simultaneous wireless information and power transfer.

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“…3 Miniaturization allows for manufacture of portable, 4 implantable, 5 and even injectable devices. 6 Current top-down nanofabrication techniques have been effective in meeting the global demands of increased capacity per unit area and lowered costs for improved devices. New technologies, such as 3-D integration 7 and new materials for interconnects, 8 will help to continue these advances.…”

Section: Introductionmentioning

confidence: 99%