Injectable poly-L-lactic acid for cosmetic enhancement: Learning from the European experience

Investigator Global Evaluations of Efficacy of Injectable Poly-L-Lactic Acid Versus Human Collagen in the Correction of Nasolabial Fold Wrinkles

“…11,12,16 Most AE resolved spontaneously; no serious AE were reported. 14,26 A limitation of the current study was that the IGE scores of improvement were not blinded. However, this is consistent with normal clinical practice, in which the clinician will examine the degree of volume replacement and, after discussion with the patient, determine the next steps.…”

Adverse reactions to injectable soft tissue fillers

“…[104][105][106][107][108][109][110][111][112][113] Injectable poly-L-lactic acid is a biocompatible, biodegradable, synthetic filler that must be injected into the reticular dermis or subcutaneous fat. In animal models, this synthetic polymer seems to be able to stimulate the activity and proliferation of dermal fibroblasts with subsequent endogenous production of collagen.…”

“…A significant reduction of the frequency of the nonvisible but palpable nodules has been achieved with higher reconstitution volume of the injected filler (5 mL of sterile water for injection rather than 3 mL), a longer time between reconstitution and injection (36-48 hours rather than 2-12 hours), injections into the subcutaneous tissue rather into the reticular dermis, and postinjection massage. 108,111 Like with other fillers, local shortterm, injection-related adverse events are frequent, including erythema, bruising, swelling, pain, inflammation, and pruritus, but they resolve spontaneously in a few days. Late-onset infections and histopathologically confirmed foreign body granulomas at the sites of injection have also been described [121][122][123][124][125][126][127] (Fig 7).…”

Estudio clínico de eficacia, duración y efectos adversos del implante de ácido hialurónico en área buco-maxilo-facial

“…Although the literature suggests numerous materials (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17) for increasing the volume of soft tissues, HA (1-6,10-17,20-52) , silicone (1,5,(53)(54) , polylactic acid (5,12,(55)(56)(57)(58)(59)(60)(61) , autologous fat (1,5,12,(62)(63)(64) , collagen (1,5,12,(65)(66)(67)(68)(69)(70) , Ca hydroxyapatite (1,5,12,(71)(72)(73)…”