Investigator Global Evaluations of Efficacy of Injectable Poly-L-Lactic Acid Versus Human Collagen in the Correction of Nasolabial Fold Wrinkles

Abstract

IGE of improvement were significantly greater with injectable PLLA treatment than with human collagen treatment at all time points following the last treatment. Injectable PLLA treatment continued to show a beneficial effect for up to 25 months.

Injectable Poly-l-Lactic Acid for Human Immunodeficiency Virus–Associated Facial Lipoatrophy: Cumulative Year 2 Interim Analysis of an Open-Label Study (FACES)

“…In addition to injectable PLLA, other treatments and devices have been investigated for facial lipoatrophy, and studies using autologous fat transfer, collagen, hyaluronic acid, injectable silicone, injectable polyacrylamide hydrogel, calcium hydroxylapatite, and polymethylmethacrylate have shown varying results. Still, safety data for subjects with darker skin, data from long‐term studies of current treatments for HIV‐associated facial lipoatrophy, and data comparing results in men and women are generally lacking …”

Effects of Sculptra® (Injectable Poly-L-Lactic Acid): A Systematic Review for Facial Rejuvenation

“…All of them were written in English, with the exception of Masveyraud (2011), written in French (Masveyraud, 2011). Regarding the study type, three were randomized clinical trials (Brandt, 2011;Brown, 2011;Narins, 2010), two prospective cohorts (Bravo and Carvalho, 2021;Chen, 2015), and three retrospective cohorts (Masveyraud, 2011;Fabi and Goldman, 2021;Palm, 2010). All studies aimed to evaluate the effi cacy and/or safety of Sculptra® injectable PLLA in facial rejuvenation (Brandt, 2011;Bravo and Carvalho, 2021;Brown, 2011;Chen, 2015;Fabi and Goldman, 2021;Masveyraud, 2011;Narins, 2010;Palm, 2010).…”

Dermal Fillers: An Update

“…The safety and efficacy of PLLA for soft-tissue augmentation are well established, with over 20 studies in more than 4000 patients [17][18][19][20]. However, several treatment sessions are required for optimal facial volume restoration, and the main concern about PLLA injection is the delayed effect of nonvisible palpable nodules and visible papules.…”

“…According to a blinded evaluator, 77 % of subjects at week 8 and 59 % of subjects at week 24 following upper and lower lip injections were considered to have a one-grade or greater change on the 5-point Medicis Lip Fullness Scale. For subjects receiving additional injections for correction of perioral rhytides, there was a statistically significant and clinically meaningful improvement in perioral rhytides as assessed by the blinded evaluator at weeks [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. No serious adverse events occurred.…”