Injectable microfluidic hydrogel microspheres based on chitosan and poly(ethylene glycol) diacrylate (PEGDA) as chondrocyte carriers

Lin, Lin; Wang, Yanfang; Pan, Jinhe; Xu, Yichao; Li, Shiyu; Huang, Da; Chen, Jiali; Liang, Zilu; Yin, Panjing; Li, Yanbin; Zhang, Hongwu; Wu, Yaobin; Zeng, Chun; Huang, Wenhua

doi:10.1039/d0ra07318k

Cited by 24 publications

(20 citation statements)

References 63 publications

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“…Subsequently, a novel kind of porous PLGA/chitosan polyelectrolyte complex MC was developed by electrostatic interaction using the emulsion-solidification technique combined with freeze-drying for its simple operation and easy scalability [ 144 ]. Another study that attempted to address the poor mechanical properties of chitosan, involved preparation of size-controllable chitosan/PEGDA hydrogel MCs using a water-in-oil approach after photo-crosslinking and physical-crosslinking, results showed that these cell-laden MCs were self-assembled into a 3D cartilage-like scaffold [ 145 ]. Furthermore, many studies have indicated that the physical properties of chitosan were mainly affected by the molecular weight, the sequence of the acetamido/amino groups, and the purity of the product [ 146 , 147 ].…”

Section: Appropriate Materials For Microcarriers In Cartilage Tementioning

confidence: 99%

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Ding

Liu

Zhao

et al. 2022

Bioactive Materials

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Section: Appropriate Materials For Microcarriers In Cartilage Tementioning

confidence: 99%

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Ding

Liu

Zhao

et al. 2022

Bioactive Materials

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“…Lin et al. used microfluidic technology to prepare chitosan/PEGDA hydrogel microspheres (CP-MSSs) with controllable size via the oil-in-water method after photo-crosslinking and physical crosslinking [ 121 ]. The results showed that cp-MSSs loaded with chondrocytes could be used for injection, and the cell viability was still high after injection.…”

Section: Microsphere Processing Materialsmentioning

confidence: 99%

Progress in the application of sustained-release drug microspheres in tissue engineering

Ruan¹,

Su²,

Qin³

et al. 2022

Materials Today Bio

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“…Therefore, it is difficult to synthesize nanodrugs with the same qualities quickly, accurately and repeatedly. Microfluidic technology might help solve the problem of inconsistent effects from laboratory research to clinical experiments given its high-speed self-assembly, narrow size distribution, and good repeatability [ 229 ].…”

Section: Clinical Application and Translationmentioning

confidence: 99%

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

et al. 2021

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Ginsenosides, the main components isolated from Panax ginseng, can play a therapeutic role by inducing tumor cell apoptosis and reducing proliferation, invasion, metastasis; by enhancing immune regulation; and by reversing tumor cell multidrug resistance. However, clinical applications have been limited because of ginsenosides’ physical and chemical properties such as low solubility and poor stability, as well as their short half-life, easy elimination, degradation, and other pharmacokinetic properties in vivo. In recent years, developing a ginsenoside delivery system for bifunctional drugs or carriers has attracted much attention from researchers. To create a precise treatment strategy for cancer, a variety of nano delivery systems and preparation technologies based on ginsenosides have been conducted (e.g., polymer nanoparticles [NPs], liposomes, micelles, microemulsions, protein NPs, metals and inorganic NPs, biomimetic NPs). It is desirable to design a targeted delivery system to achieve antitumor efficacy that can not only cross various barriers but also can enhance immune regulation, eventually converting to a clinical application. Therefore, this review focused on the latest research about delivery systems encapsulated or modified with ginsenosides, and unification of medicines and excipients based on ginsenosides for improving drug bioavailability and targeting ability. In addition, challenges and new treatment methods were discussed to support the development of these new tumor therapeutic agents for use in clinical treatment.

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Injectable microfluidic hydrogel microspheres based on chitosan and poly(ethylene glycol) diacrylate (PEGDA) as chondrocyte carriers

Abstract: Chitosan/PEGDA double-network hydrogel microspheres prepared by microfluidic method as chondrocyte carriers for bottom-up cartilage tissue engineering.

Cited by 24 publications

References 63 publications

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Microcarriers in application for cartilage tissue engineering: Recent progress and challenges

Progress in the application of sustained-release drug microspheres in tissue engineering

Ginsenosides emerging as both bifunctional drugs and nanocarriers for enhanced antitumor therapies

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