Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel

Cho, Jung Kyo; Hong, Ki Yun; Park, Jung Won; Yang, Han–Kwang; Song, Soo‐Chang

doi:10.3109/1061186x.2010.499461

Cited by 56 publications

(42 citation statements)

References 44 publications

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“…Clinical use of 2ME 2 is mainly limited by its poor water solubility and low bioavailability [125,126]. Indeed, a clinical trial of 2ME 2 was cancelled because its plasma concentrations after oral administration were lower than the effective dose [127].…”

Section: Clinical Use Of 2-methoxyestradiolmentioning

confidence: 99%

Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease

Parada-Bustamante¹,

Valencia²,

Reuquén³

et al. 2015

MRMC

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Estradiol (E2) is a steroid hormone whose physiological actions are mainly mediated by its interaction with intracellular estrogen receptors (ER) leading to modification on the mRNA and protein synthesis in its target cells. However, estrogens can also activate several intracellular signal transduction cascades by non-genomic mechanisms. Estrogens must be inactivated and removed from blood through its conversion to soluble compounds with an apparent low estrogenic activity and decreased affinity for ER. In this context, 2-methoxyestradiol (2ME2) is generated by a sequential hydroxylation of E2 via the enzyme cytochrome P450 isoform 1A1 to produce 2-hydroxyestradiol (2OHE2) followed by a conjugation reaction catalyzed by the enzyme Catechol-O-Methyltransferase generating 2ME2 from 2OHE2. Recent evidence indicates that physiological concentration of 2ME2 may regulate several biological processes while high concentrations of this metabolite may induce pathophysiological alterations in several tissues. In the last years, 2ME2 has also been described as a promising anticancer drug although its cellular and molecular mechanisms are still being disclosed. Herein, we will review the available literature concerning the role of 2ME2 in health and disease. We will focus on to describing the intracellular mechanisms by which 2ME2 exerts its effects on reproductive and non-reproductive tissues. The promising anticancer effects of 2ME2 and its synthetic derivatives will also be discussed. Finally, a group of 2ME2-target genes that could be used as biomarkers of 2ME2 under physiological or pathophysiological conditions will be reviewed.

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Section: Clinical Use Of 2-methoxyestradiolmentioning

confidence: 99%

Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease

Parada-Bustamante¹,

Valencia²,

Reuquén³

et al. 2015

MRMC

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“…12,[288][289][290][291][292][293][294] In addition, carboxylic acid on PPP has been used as a conjugation site for anticancer drugs such as paclitaxel, doxorubicin, and camptothecin. 291,292,295 The anticancer drug release behaviors of the conjugated in situ-forming PEG-PPP hydrogels relies on the physicochemical properties, hydrolytic degradation, and the composition of the substitution groups on PPP.…”

Section: Peg and Polyphosphazenes (Ppps)mentioning

confidence: 99%

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Kim

Kwon

et al. 2015

Polymer Reviews

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Research on injectable in situ-forming hydrogels has been conducted in diverse biomedical applications for a long period. These hydrogels exhibit sol-to-gel phase transition in accordance with the external stimuli such as temperature change. Also, unlike the traditional surgical procedures the hydrogels have the distinct properties of easy management and minimal invasiveness via simple aqueous state injections at target sites. Currently, numerous polymer materials have been reported as potential stimulusinduced in situ-forming hydrogels. In this review, a comprehensive overview of the state-of-the-art of these rapidly developing materials has been outlined. In situ-forming hydrogels formed by electrostatic and hydrophobic interactions as well as their mechanistic characteristics and biomedical applications in regenerative medicine have also been discussed. The review concludes with perspectives on the future of stimulus-induced in situ-forming hydrogels.

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“…Cho ve ark.nın araştırmalarında, anjiyogenik inhibitör olan 2-metoksiöstradiol sıcaklık duyarlı poli (organofosfazen) içine yüklenmiştir. 12…”

Section: Sicakliğa Duyarli Hidrojellerin Kontrollü Salim Sistemi Uyguunclassified

Thermosensitive Hydrogels for Controlled Drug Delivery

Arısoy¹,

Dortunç²

2020

J Lit Pharm Sci

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SICaKLIK DuYaRLI hiDROjELLERE gENEL BaKIş Hidrojeller; çapraz bağlı polimerlerden oluşan üç boyutlu, gözenekli bir yapıya sahiptir. 1 Yüksek su tutma kapasitesi ve toksik olmayan yapıları nedeniyle doku mühendisliğinde ve bölgesel ilaç hedeflendirmede yaygın olarak kullanılmaktadır. Hidrojeller, klasik ve uyarıya duyarlı olarak ikiye ayrılır. Uyarı duyarlı, diğer bir deyişle akıllı hidrojellerin şişme dengeleri pH, sıcaklık, elektriksel ortam ya da diğer çevresel uyarılar ile hızla değişebilmektedir. Akıllı hidrojeller bu niteliklerine göre sıcaklık duyarlı, pH duyarlı,

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Injectable delivery system of 2-methoxyestradiol for breast cancer therapy using biodegradable thermosensitive poly(organophosphazene) hydrogel

Cited by 56 publications

References 44 publications

Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease

Role of 2-methoxyestradiol, an Endogenous Estrogen Metabolite, in Health and Disease

Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines

Thermosensitive Hydrogels for Controlled Drug Delivery

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