Injectable and self-healing polysaccharide-based hydrogel for pH-responsive drug release

Qian, Chao Nan; Zhang, Tingbin; Gravesande, Joel; Baysah, Charles; Song, Xiaoyan; Xing, Jinfeng

doi:10.1016/j.ijbiomac.2018.11.048

Cited by 115 publications

(79 citation statements)

References 47 publications

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“…In order to confirm the formation of covalent crosslinks between the CMCh and HAox components of the printing mixture, the CMCh2/HAox4-HA0.4 formulation was characterized by FTIR spectroscopy (see Figure S2 ). The characteristic peaks corresponding to the functional groups of the CMCh and HAox/HA precursors were observed in the mixture [ 56 , 57 , 62 ], together with a band at 1653 cm −1 , which can be attributed to the stretching vibration of the C=N bond of the Schiff base formed by a reaction of amine and aldehyde groups. This indicates that covalent crosslinking was successfully achieved [ 63 , 64 , 74 ].…”

Section: Resultsmentioning

confidence: 99%

“…This degradation rate is slightly faster than previously reported for CMCh/HAox injectable hydrogels (10–14 days) [ 63 , 74 , 75 ], which can be assigned to the higher surface area and open structure of the grid scaffold that makes them more sensitive for degradation. Schiff’s base crosslinked hydrogels have low stability due to the dynamic nature of the bond [ 57 , 78 , 79 ]. Thus, to increase the long-term stability of the scaffolds, a new crosslinking approach was proposed since stability is directly related to the crosslinking degree of the hydrogel [ 76 , 80 , 81 ].…”

Section: Resultsmentioning

confidence: 99%

“…Chitosan is a great candidate for tissue engineering applications since it exhibits notable biological features such as great cytocompatibility and biodegradability, antibacterial, hemostatic, or muco-adhesive properties [ 54 , 55 ]. Specifically, a carboxymethyl chitosan derivative (CMCh) was selected because of its good solubility at physiological pH, which allows straightforward encapsulation of cells in the bio-ink [ 56 , 57 ] and avoids any neutralization or washing steps, commonly used for pure chitosan-based printing [ 28 , 49 , 58 , 59 ]. Hyaluronic acid (HA) is an important component of the extracellular matrix (ECM), which favors cell affinity and proliferation [ 60 , 61 ].…”

Section: Introductionmentioning

confidence: 99%

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3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool

et al. 2020

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Hydrogel-based bio-inks have recently attracted more attention for 3D printing applications in tissue engineering due to their remarkable intrinsic properties, such as a cell supporting environment. However, their usually weak mechanical properties lead to poor printability and low stability of the obtained structures. To obtain good shape fidelity, current approaches based on extrusion printing use high viscosity solutions, which can compromise cell viability. This paper presents a novel bio-printing methodology based on a dual-syringe system with a static mixing tool that allows in situ crosslinking of a two-component hydrogel-based ink in the presence of living cells. The reactive hydrogel system consists of carboxymethyl chitosan (CMCh) and partially oxidized hyaluronic acid (HAox) that undergo fast self-covalent crosslinking via Schiff base formation. This new approach allows us to use low viscosity solutions since in situ gelation provides the appropriate structural integrity to maintain the printed shape. The proposed bio-ink formulation was optimized to match crosslinking kinetics with the printing process and multi-layered 3D bio-printed scaffolds were successfully obtained. Printed scaffolds showed moderate swelling, good biocompatibility with embedded cells, and were mechanically stable after 14 days of the cell culture. We envision that this straightforward, powerful, and generalizable printing approach can be used for a wide range of materials, growth factors, or cell types, to be employed for soft tissue regeneration.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool

et al. 2020

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“…Artificial tissue Deng Z. et al, 2018;Ghanian et al, 2018;Lee et al, 2018;Chen et al, 2019b;Guo Z. et al, 2019;Shao et al, 2019;Sun C. et al, 2019 Drug/cell delivery Qu et al, 2017;Yang et al, 2017;Deng Z. et al, 2018;Khan et al, 2018;Sharma et al, 2018;Wei and Gerecht, 2018;Zhi et al, 2018;Balakrishnan et al, 2019;Chen et al, 2019e;Guo B. et al, 2019;Jiang F. et al, 2019;Li Q. et al, 2019;Liu P. et al, 2019;Qian et al, 2019;Shen et al, 2019;Sun C. et al, 2019;Xu H. et al, 2019 Electrical devices Liao et al, 2017;Ding et al, 2018;Jing et al, 2018;Li R. et al, 2019;Pan et al, 2018;Shao et al, 2018;Wang S. et al, 2018;Becher et al, 2019;Chen et al, 2019c;Deng et al, 2019;Han et al, 2019;Hu et al, 2019;Lin et al, 2019;Peng et al, 2019;Qiao et al, 2019;Qin et al, 2019;Rao et al, 2019;Shin et al, 2019;…”

Section: Potential Application Referencesunclassified

“…Those networks can be mainly divided into two cross-linking types: (1) dynamic chemical covalent bonds and (2) physical non-covalent interactions. Dynamic covalent bonds include imine bond ( Qu et al, 2017 ; Yan et al, 2017 ; Chen H. et al, 2018 ; Chen et al, 2019e ; Khan et al, 2018 ; Wei and Gerecht, 2018 ; Zhang et al, 2018 ; Guo B. et al, 2019 ; Jiang F. et al, 2019 ; Li Q. et al, 2019 ; Qian et al, 2019 ; Wang et al, 2019b ; Wang W. et al, 2019 ; Zhou et al, 2019 ), Diels–Alder (DA) reaction ( Oehlenschlaeger et al, 2014 ), boronate-diol complexation ( Hong et al, 2018 ; Pan et al, 2018 ; Smithmyer et al, 2018 ; Zhi et al, 2018 ; Han et al, 2019 ), acylhydrazone bond ( Yang et al, 2017 ; Shen et al, 2019 ; Sun C. et al, 2019 ), dynamic disulfide bond ( Song L. et al, 2019 ), and dynamic metal oordination ( Shao et al, 2018 ; Chen et al, 2019a ; Qin et al, 2019 ). Physical non-covalent interactions include hydrogen bonding ( Fan et al, 2018 ; Uzumcu et al, 2018 ; Cao et al, 2019 ; Chen et al, 2019c ; Hu et al, 2019 ; Huang et al, 2019 ; Kuddushi et al, 2019 ; Li R. et al, 2019 ; Liao et al, 2019 ; Su et al, 2019 ; Wang L. et al, 2019 ), hydrophobic interaction ( Liu P. et al, 2019 ), host-guest interaction ( Deng Z. et al, 2018 ; Li Q. et al, 2018 ; Liu L. et al, 2019 ; Wang W. et al, 2019 ), and ionic interaction ( Ma et al, 2018 ; Wang Y. et al, 2018 ; Becher et al, 2019 ).…”

Section: Introductionmentioning

confidence: 99%

Advances in Synthesis and Applications of Self-Healing Hydrogels

Fan

Qian

et al. 2020

Front. Bioeng. Biotechnol.

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Background: Hydrogels, a type of three-dimensional (3-D) crosslinked network of polymers containing a high water concentration, have been receiving increasing attention in recent years. Self-healing hydrogels, which can return to their original structure and function after physical damage, are especially attractive. Some selfhealable hydrogels have several kinds of properties such as injectability, adhesiveness, and conductivity, which enable them to be used in the manufacturing of drug/cell delivery vehicles, glues, electronic devices, and so on. Main Body: This review will focus on the synthesis and applications of self-healing hydrogels. Their repair mechanisms and potential applications in pharmaceutical, biomedical, and other areas will be introduced. Conclusion: Self-healing hydrogels are used in various fields because of their ability to recover. The prospect of self-healing hydrogels is promising, and they may be further developed for various applications.

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Degradable Self‐healable Networks for Use in Biomedical Applications

Grosjean

Gangolphe

Nottelet

2023

Adv Funct Materials

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Among biomaterials, 3D networks with capacities to absorb and retain large quantities of water (hydrogels) or withstand significant deformation and stress while recovering their initial structures at rest (elastomers) are largely used in biomedical applications. However, when damaged, they cannot recover their initial structures and properties. To overcome this limitation and satisfy the requirements of the biomedical field, self-healable hydrogels and elastomers designed using (bio)degradable or bioeliminable polymer chains have been developed and are becoming increasingly popular. This review presents the latest advances in the field of self-healing degradable/bioeliminable networks designed for use in health applications. The strategies used to develop such networks based on reversible covalent or physical cross-linking or their combination via dual/multi-cross-linking approaches are analyzed in detail. The key parameters of these hydrogels and elastomers, such as mechanical properties, repair and degradation times, and healing efficiencies, are critically considered in terms of their suitabilities in biomedical applications. Finally, their current and prospective uses as biomaterials in the fields of tissue engineering, drug/cell delivery, and medical devices are presented, followed by the remaining challenges faced to ensure the further success of degradable self-healable networks.

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Injectable and self-healing polysaccharide-based hydrogel for pH-responsive drug release

Cited by 115 publications

References 47 publications

3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool

3D Printing of a Reactive Hydrogel Bio-Ink Using a Static Mixing Tool

Advances in Synthesis and Applications of Self-Healing Hydrogels

Degradable Self‐healable Networks for Use in Biomedical Applications

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