Injectable and pH-responsive self-assembled peptide hydrogel for promoted tumor cell uptake and enhanced cancer chemotherapy

Zhang, Jiamin; Lin, Wenjing; Yang, Lijun; Zhang, Aijie; Liu, Jinjian; Liu, Jianfeng

doi:10.1039/d1bm01788h

Cited by 36 publications

(27 citation statements)

References 52 publications

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“…From a chemical point of view, drugs are incorporated within hydrogels by two general modalities, through either chemical or physical interactions. In a recent work, Zhang et al developed a pH-responsive and injectable peptide hydrogel–MTX delivery system for local and specific tumor chemotherapy, which afforded low side effects [ 76 ]. A hydrophilic drug, methotrexate (MTX) was conjugated to the peptide chain (KKFKFEFEF) using a pH-responsive linker, 2,3-dimethylmaleic anhydride, via the formation of amidic bonds.…”

Section: Biomedical Applications Of Peptide-based Hydrogelsmentioning

confidence: 99%

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

et al. 2022

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Peptide-based hydrogels have attracted increasing attention for biological applications and diagnostic research due to their impressive features including biocompatibility and biodegradability, injectability, mechanical stability, high water absorption capacity, and tissue-like elasticity. The aim of this review will be to present an updated report on the advancement of peptide-based hydrogels research activity in recent years in the field of anticancer drug delivery, antimicrobial and wound healing materials, 3D bioprinting and tissue engineering, and vaccines. Additionally, the biosensing applications of this key group of hydrogels will be discussed mainly focusing the attention on cancer detection.

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Section: Biomedical Applications Of Peptide-based Hydrogelsmentioning

confidence: 99%

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

et al. 2022

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“…This approach has been recently widely applied in the field of pH-responsive self-assembling peptide-based biomaterials, as the nonfunctional molecule becomes functional when the pH changes, providing a specific and “smart” target treatment. Various pH-labile linkages such as hydrazones, cis -aconityls, dimethylmaleic amides, and acetals (Figure B) are commonly used in pH-responsive systems. For example, Balci and Top designed a pH-responsive drug delivery system by conjugating mPEG-peptide with Dox via an acid cleavable hydrazone bond to evaluate drug release under normal and acidic conditions .…”

Section: Design and Self-assembling Behavior Of Ph-responsive Peptide...mentioning

confidence: 99%

pH-Responsive Self-Assembling Peptide-Based Biomaterials: Designs and Applications

Zhao

Zhu

Matson

2022

ACS Appl. Bio Mater.

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Stimuli-responsive peptide-based biomaterials are increasingly gaining interest for various specific and targeted treatments, including drug delivery and tissue engineering. Among all stimuli, pH can be especially useful because endogenous pH changes are often associated with abnormal microenvironments. pH-Responsive amino acids and organic linkers can be easily incorporated into peptides that self-assemble into various nanostructures. Thus, these largely biocompatible and easily tunable platforms are ideal candidates for drug release and as fibrous materials capable of mimicking the native extracellular matrix. In this review, we highlight common design motifs and mechanisms of pH-responsiveness in self-assembling peptide-based biomaterials, focusing on recent advances of these biomaterials applied in drug delivery and tissue engineering. Finally, we suggest future challenges and areas for potential development in pH-responsive self-assembling peptide-based biomaterials.

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“…Zhang et al developed an injectable pH-responsive drug–peptide hydrogel for local chemotherapy [ 52 ]. Firstly, methotrexate (MTX), a small-molecule drug with carboxyl groups and 2,3-dimethylmaleic anhydride (DA), a pH-responsive linker, were directly conjugated onto the KKFKFEFEF peptide chain via the amidation reaction, achieving a drug-loaded pH-responsive peptide composite (MTX-KKFKFEFEF(DA)).…”

Section: Classification Of Smart In Situ Hydrogelsmentioning

confidence: 99%

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

et al. 2022

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Cancer seriously threatens human health. Surgery, radiotherapy and chemotherapy are the three pillars of traditional cancer treatment, with targeted therapy and immunotherapy emerging over recent decades. Standard drug regimens are mostly executed via intravenous injection (IV), especially for chemotherapy agents. However, these treatments pose severe risks, including off-target toxic side effects, low drug accumulation and penetration at the tumor site, repeated administration, etc., leading to inadequate treatment and failure to meet patients’ needs. Arising from these challenges, a local regional anticancer strategy has been proposed to enhance therapeutic efficacy and concomitantly reduce systemic toxicity. With the advances in biomaterials and our understanding of the tumor microenvironment, in situ stimulus-responsive hydrogels, also called smart hydrogels, have been extensively investigated for local anticancer therapy due to their injectability, compatibility and responsiveness to various stimuli (pH, enzyme, heat, light, magnetic fields, electric fields etc.). Herein, we focus on the latest progress regarding various stimuli that cause phase transition and drug release from smart hydrogels in local regional anticancer therapy. Additionally, the challenges and future trends of the reviewed in situ smart hydrogels for local drug delivery are summarized and proposed.

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Injectable and pH-responsive self-assembled peptide hydrogel for promoted tumor cell uptake and enhanced cancer chemotherapy

Abstract: An injectable, pH-responsive, in situ self-assembled drug-peptide hydrogel (MTX-KKFKFEFEF(DA)) for highly efficient local tumor chemotherapy.

Cited by 36 publications

References 52 publications

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

Peptide-Based Hydrogels: New Materials for Biosensing and Biomedical Applications

pH-Responsive Self-Assembling Peptide-Based Biomaterials: Designs and Applications

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

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