Initial Interactions of Chlamydiae with the Host Cell

Hackstadt, Ted

doi:10.1128/9781555817329.ch6

Cited by 5 publications

(21 citation statements)

References 136 publications

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“…The bacteria divide by binary fission and the inclusion substantially expands. For some species, such as C. trachomatis , the infection of a single cell by several elementary bodies generates individual inclusions that fuse with each other by homotypic fusion 16,21 . At late stages (~24–72 hours post-infection for C. trachomatis ), reticulate bodies transition to elementary bodies in an asynchronous manner, which might be stimulated by their detachment from the inclusion membrane 11 .…”

Section: The Developmental Cyclementioning

confidence: 99%

“…relies on numerous host and bacterial factors 16–18 (FIGS 1,2a). The diversity in binding and internalization mechanisms between species probably contributes to differences in tropism for specific hosts and tissues.…”

Section: Binding and Invasionmentioning

confidence: 99%

“…Finally, protein disulfide isomerase (PDI), a component of the oestrogen receptor complex, is implicated in the attachment and entry of many Chlamydia spp. 16,18 . PDI may also reduce the disulfide bonds in adhesins, host receptors and/or the T3SS 13,38 .…”

Section: Binding and Invasionmentioning

confidence: 99%

“…The activation of RAC1 results in the recruitment of the actin regulators, Wiskott–Aldrich syndrome protein family member 2 (WAVE2; also known as WASF2), ABL interactor 1 (ABI1), actin-related protein 2 (ARP2) and ARP3, which are necessary for the reorganization of actin 18 . Actin polymerization is accompanied by extensive membrane remodelling 16,39,40 , which is driven by several host factors, including caveolin, clathrin and cholesterol-rich microdomains 7,41 .…”

Section: Binding and Invasionmentioning

confidence: 99%

“…2a). Translocated actin-recruiting phosphoprotein (TarP; also known as CT456) is a multidomain protein that nucleates and bundles actin through its own globular actin (G-actin) and filamentous actin (F-actin) domains and is thought to synergize with the host ARP2/3 complex 16,43 . In addition, TarP in C. caviae contains a mammalian leucine–aspartic acid (LD2)-like motif that subverts focal adhesion kinase (FAK) signalling 44 .…”

Section: Binding and Invasionmentioning

confidence: 99%

See 4 more Smart Citations

Chlamydia cell biology and pathogenesis

2016

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Chlamydia spp. are important causes of human disease for which no effective vaccine exists. These obligate intracellular pathogens replicate in a specialized membrane compartment and use a large arsenal of secreted effectors to survive in the hostile intracellular environment of the host. In this Review, we summarize the progress in decoding the interactions between Chlamydia spp. and their hosts that has been made possible by recent technological advances in chlamydial proteomics and genetics. The field is now poised to decipher the molecular mechanisms that underlie the intimate interactions between Chlamydia spp. and their hosts, which will open up many exciting avenues of research for these medically important pathogens.

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Section: The Developmental Cyclementioning

confidence: 99%

Section: Binding and Invasionmentioning

confidence: 99%

Section: Binding and Invasionmentioning

confidence: 99%

Section: Binding and Invasionmentioning

confidence: 99%

Section: Binding and Invasionmentioning

confidence: 99%

See 3 more Smart Citations

Chlamydia cell biology and pathogenesis

2016

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Chlamydia: what is on the outside does matter

Gitsels

Lent

Sanders

et al. 2020

Critical Reviews in Microbiology

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Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease

Turin

Surini

Wheelhouse

et al. 2022

Vet Res

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Environmental transmission of Chlamydia abortus as a result of enzootic disease or disease outbreaks and the threats posed by this pathogen has been previously reported, however a state-of-the-science review of these reports and the identification of future research priorities in this area is still lacking. This study provides an overview of the current knowledge of host–pathogen–environment interactions, addressing public health risks and identifying critical questions and research gaps. We performed a systematic PubMed and Web of Science search for publications related to Chlamydia abortus in the past four decades, and we reviewed and combined the evidence critically discussing and commenting the results. A total of 182 studies, 5 chapters of specific books and the “OIE terrestrial manual” were included in this review. There were substantial variations between the studies in topic addressed and experimental design. Overall, the literature largely supports the crucial role played by environmental exposure on the acquisition of zoonotic disease caused by Chlamydia abortus. We also identify the paucity of information related to interspecies transmission and pathogen adaptation in relation to environmental dissemination and zoonotic risk. This analysis further highlights the need for additional research given that environmental transmission represents a serious risk not only to susceptible patients (pregnant women and immunocompromised individuals), but also for other species including wildlife.

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Initial Interactions of Chlamydiae with the Host Cell

Cited by 5 publications

References 136 publications

Chlamydia cell biology and pathogenesis

Chlamydia cell biology and pathogenesis

Chlamydia: what is on the outside does matter

Recent advances and public health implications for environmental exposure to Chlamydia abortus: from enzootic to zoonotic disease

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