Initial human experience of endoscopic ultrasound-guided photodynamic therapy with a novel photosensitizer and a flexible laser-light catheter

Abstract

These preliminary data suggest that EUS-guided PDT with a second-generation photosensitizer and a flexible laser probe is feasible and safe.

Outcomes after endoscopic ultrasound‐guided ethanol‐lipiodol ablation of small pancreatic neuroendocrine tumors

“…Currently, no data exist with respect to a positive effect of surgery on overall survival in small (<2 cm) non‐functioning pancreatic neuroendocrine tumors (PNET) . Given the considerable risks related to pancreatic surgery, a minimally invasive endoscopic ultrasonography (EUS)‐guided ablative technique might therefore have a role in this setting …”

“…1,2 Given the considerable risks related to pancreatic surgery, a minimally invasive endoscopic ultrasonography (EUS)-guided ablative technique might therefore have a role in this setting. [3][4][5][6] A pilot study using ethanol ablation to treat PNET showed that the complete ablation rate was 61%; however, pancreatitis occurred in 27% of cases. 7 Different methods of improving ablative efficacy, as well as avoiding the risk of pancreatitis, should be explored.…”

Endolysosomal targeting of a clinical chlorin photosensitiser for light-triggered delivery of nano-sized medicines

“…Many clinical PDT photosensitisers such as chlorin e 6 or mTHPC are administered using a delivery system to improve water solubility consisting of an emulsion or liposomes (eg Verteporfin, which is formulated in liposomes as Visudyne) 9, 10 . The clinical formulation of chlorin e 6 (Photolon) contains polyvinylprrrolidone (PVP) which is a synthetic neutral polymer used to aid drug dissolution and disaggregation 33, 34 . There are several recent studies investigating new routes to improve chlorin e 6 delivery using other solubilising agents 35–37 and nanoparticles 38, 39 which underscore the interest in improving the pharmacokinetic properties of this photosensitiser.…”

Endoscopic Ultrasound-Guided Direct Intervention for Solid Pancreatic Tumors

“…The first clinical experience with EUS-PDT in pancreatic cancer has been published in 2015 [53]. Four patients with locally advanced pancreaticobiliary cancers were included.…”