Initial Gastrointestinal Manifestations in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 112 Patients From Veracruz in Southeastern Mexico

Remes-Troche, José María; Ramos-de-la-Medina, Antonio; Manríquez-Reyes, Marisol; Martínez-Pérez-Maldonado, Laura; Lara, Elizabeth Lagunes; Solís-González, María Antonieta

doi:10.1053/j.gastro.2020.05.055

Cited by 34 publications

(36 citation statements)

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“…Among the included studies, 26 studies were conducted in China [ 10 – 13 , 26 – 47 ], 8 in USA [ 48 – 55 ], 7 in Italy [ 16 , 56 – 61 ], 4 in Spain [ 14 , 62 – 64 ], 2 in South Korea [ 65 , 66 ], 2 in Mexico [ 67 , 68 ], 1 in Bangladesh [ 69 ], 1 in Brazil [ 70 ], 1 in England [ 71 ], I in Greece [ 72 ], 1 in Iran [ 73 ], 1 in Kuwait [ 74 ], 1 in Switzerland [ 75 ], 1 in Turkey [ 76 ] and 1 in few European countries [ 77 ]. The sample size of the included studies varied from 16 to 51,633 patients and the mean age of the included patients varied from 41 years to 85.5 years.…”

Section: Resultsmentioning

confidence: 99%

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis

2020

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Objectives The main aim of this study was to find the prevalence of mortality among hospitalized COVID-19 infected patients and associated risk factors for death. Methods Three electronic databases including PubMed, Science Direct and Google Scholar were searched to identify relevant cohort studies of COVID-19 disease from January 1, 2020, to August 11, 2020. A random-effects model was used to calculate pooled prevalence rate (PR), risk ratio (RR) and 95% confidence interval (CI) for both effect measures. Cochrane chi-square test statistic Q, I 2 , and 2 tests were used to measure the presence of heterogeneity. Publication bias and sensitivity of the included studies were also tested. Results In this meta-analysis, a total of 58 studies with 122,191 patients were analyzed. The pooled prevalence rate of mortality among the hospitalized COVID-19 patients was 18.88%, 95% CI (16.46-21.30), p < 0.001. Highest mortality was found in Europe [PR 26.85%, 95% CI (19.41-34.29), p < 0.001] followed by North America [PR 21.47%, 95% CI (16.27-26.68), p < 0.001] and Asia [PR 14.83%, 95% CI (12.46-17.21), p < 0.001]. An significant association were found between mortality among COVID-19 infected patients and older age (> 65 years vs. < 65 years) [RR 3.59, 95% CI (1.87-6.90), p < 0.001], gender (male vs. female) [RR 1.63, 95% CI (1.43-1.87), p < 0.001], ICU admitted patients [RR 3.72, 95% CI (2.70-5.13), p < 0.001], obesity [RR 2.18, 95% CI (1.10-4.34), p < 0.05], hypertension [RR 2.08,95% CI (1.79-2.43) p < 0.001], diabetes [RR 1.87, 95% CI (1.23-2.84), p < 0.001], cardiovascular disease [RR 2.51, 95% CI (1.20-5.26), p < 0.05], and cancer [RR 2.31, 95% CI (1.80-2.97), p < 0.001]. In addition, significant association for high risk of mortality were also found for cerebrovascular disease, COPD, coronary heart disease, chronic renal disease, chronic liver disease, chronic lung disease and chronic kidney disease. Conclusion This meta-analysis revealed that the mortality rate among COVID-19 patients was highest in the European region and older age, gender, ICU patients, patients with comorbidity had a high risk for case fatality. Those findings would help the health care providers to reduce the mortality rate and combat this pandemic to save lives using limited resources.

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Section: Resultsmentioning

confidence: 99%

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis

2020

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“…Our result was further supported by the findings in existing investigations. Jiang 11 et al found that T subset of lymphocyte count in peripheral blood is down regulated in the cases of severe COVID-19 and Troche 12 et al reported that SARS-CoV-19 has shown likelihood to invade the mucosal of GI system, leading to water retention in the GI lumen and viral discharge. Furthermore, we found that lower CLC levels are significantly associated with positive PCR results in stool (Fig.…”

Section: Discussionmentioning

confidence: 99%

Virus discharge and initial gastrointestinal involvement are inversely associated with circulating lymphocyte count in COVID-19

Chen¹,

Zheng²,

Liu³

et al. 2021

Int. J. Med. Sci.

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“…SARS-CoV-2, a novel virus causing COVID-19 in addition to respiratory symptoms (1,2), may present with gastrointestinal symptoms, including diarrhea (3)(4)(5), even without respiratory complaints (6).…”

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confidence: 99%

Inflammatory Bowel Disease and COVID-19

et al. 2020

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Initial Gastrointestinal Manifestations in Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 112 Patients From Veracruz in Southeastern Mexico

Cited by 34 publications

References 8 publications

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis

Prevalence and Associated Risk Factors of Mortality Among COVID-19 Patients: A Meta-Analysis

Virus discharge and initial gastrointestinal involvement are inversely associated with circulating lymphocyte count in COVID-19

Inflammatory Bowel Disease and COVID-19

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