Virus discharge and initial gastrointestinal involvement are inversely associated with circulating lymphocyte count in COVID-19

Chen, Wei; Zheng, Kenneth I.; Liu, Saiduo; Xu, Chongyong; Xing, Chao; Qiao, Zengpei

doi:10.7150/ijms.51672

Cited by 4 publications

(5 citation statements)

References 14 publications

(14 reference statements)

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“…It is well established that the angiotensin-converting enzyme 2 receptor was responsible for SARA-CoV-2 adhesion and invasion, which widely exists in the organs such as pulmonary and GI tract [ 18 , 19 ]. Our previous study had shown that circulating lymphocyte was inversely associated with the risk of GI involvement [ 20 ]. We further explored PC ratio on the risk of GI involvement and found that PC ratio also showed a satisfactory predictive power on the risk of GI involvement ( Figure 2(b) ).…”

Section: Discussionmentioning

confidence: 99%

A Novel Predictive Model in Recognizing Severe COVID-19 and Multiorgan Injuries: Platelet-to-CRP Ratio

Chen

Zheng

Liu

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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Aims. In view of the emerging virus variations and pandemic worldwide, it is urgent to explore effective models predicting disease severity. Methods. We aimed to investigate whether platelet-to-CRP ratio (PC ratio) could predict the severity of COVID-19 and multi-organ injuries. Patients who complained of pulmonary or gastrointestinal symptoms were enrolled after confirmation of SARS-CoV-2 infection via qRT-PCR. Those who complained of gastrointestinal symptoms were defined as having initial gastrointestinal involvement. Chest computed tomography (CT) was then performed to classify the patients into mild, moderate, and severe pneumonia groups according to the interim management guideline. qRT-PCR was also performed on stool to discern those discharging virus through the gastrointestinal tract. Logistic regression models were applied to analyze the association between PC ratio and severity of pneumonia, risk of initial gastrointestinal involvement, and multi-organ injuries. Results. When compared to the bottom tertile of PC ratio, the adjusted odds ratio was −0.51, p < 0.001 and −0.53, p < 0.001 in moderate and severe pneumonia, respectively. Furthermore, the adjusted odds ratio for initial gastrointestinal involvement was 0.18 (82% lower) when compared to the bottom tertile of PC ratio, p = 0.005 . The area under ROC on moderate-to-severe pneumonia and initial gastrointestinal involvement was 0.836 (95% CI: 0.742, 0.930, p < 0.001 ) and 0.721 (95% CI: 0.604, 0.839, p = 0.002 ), respectively. The upper tertiles of PC ratio showed lower levels of aspartate aminotransferase ( p = 0.016 ) and lactic dehydrogenase ( p < 0.001 ). Conclusions. Platelet-to-CRP ratio could act as an effective model in recognizing severe COVID-19 and multi-organ injuries.

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Section: Discussionmentioning

confidence: 99%

A Novel Predictive Model in Recognizing Severe COVID-19 and Multiorgan Injuries: Platelet-to-CRP Ratio

Chen

Zheng

Liu

et al. 2022

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…Moreover, this study found a significant difference in lymphocyte count between the two groups; COVID-19 patients with GI symptoms had a higher median lymphocyte count than those without GI symptoms. In contrast, Chen et al reported a negative relationship between circulating lymphocyte count and initial GI symptoms [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of COVID-19 Patients Presenting With Gastrointestinal Symptoms

Abro¹,

Bhatti²,

Siddiqui³

2021

Cureus

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BackgroundPatients with coronavirus disease 2019 (COVID-19) usually have fever and respiratory tract complaints; however, many report gastrointestinal (GI) symptoms. The frequency of GI symptoms ranges from 16% to 61%. Although COVID-19 morbidity and mortality are related to pulmonary disease, poor outcomes have been linked to GI symptoms. Therefore, this study aimed to determine the outcomes of COVID-19 patients who presented with GI symptoms.

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“…A low lymphocyte count at hospital admission has been associated with initial GI involvement and with a higher rate of viral shedding. [42] Similarly, a study comparing COVID-19 patients with and without diarrhoea, showed that not only a reduced lymphocyte count, but also a decrease of gamma-glutamyl transferase (GGT), prealbumin and CD4-T cells might be useful in the diagnosis of GI involvement within SARS-COV-2 infection. [43] …”

Section: Methodsmentioning

confidence: 99%

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

Pegoraro

Trapani

Indolfi

2022

Clinics and Research in Hepatology and Gastroenterology

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Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a well-established respiratory tract pathogen. Recent studies in adults and children have shown an increasing number of patients reporting gastrointestinal manifestations of SARS-CoV-2 infection such as diarrhoea, nausea, vomiting and abdominal pain. SARS-CoV-2 RNA can be detected in faeces for an extended period, even after respiratory samples have tested negative and patients are asymptomatic. However, faecal-oral transmission has not yet been proven. In this article, the latest evidence on gastrointestinal, hepato-biliary, and pancreatic manifestations in children with coronavirus disease-19 and multisystem inflammatory syndrome will be analysed.

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Virus discharge and initial gastrointestinal involvement are inversely associated with circulating lymphocyte count in COVID-19

Cited by 4 publications

References 14 publications

A Novel Predictive Model in Recognizing Severe COVID-19 and Multiorgan Injuries: Platelet-to-CRP Ratio

A Novel Predictive Model in Recognizing Severe COVID-19 and Multiorgan Injuries: Platelet-to-CRP Ratio

Clinical Outcome of COVID-19 Patients Presenting With Gastrointestinal Symptoms

Gastrointestinal, hepatic and pancreatic manifestations of COVID-19 in children

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