Initial experience with polytetrafluoroethylene leaflet extensions for aortic valve repair

Nosál, Matej; Poruban, Rudolf; P, Valentik; Sagát, M; Nagi, Aref Seif; Kantorova, A

doi:10.1093/ejcts/ezr214

Cited by 28 publications

(17 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hydrophilicity/hydrophobicity determines the subsequent adhesion of blood cells and cell proliferation [47]. However, there is some evidence on using of hydrophobic biomaterials in cardiovascular implants, particularly Gore-tex TM in artificial heart valve leaflets, in clinical practice [48]. Our experimental data demonstrated the superiority of SIBS over Gore-tex TM suggesting the former beneficial potential for the application in the clinical practice.…”

Section: Discussionmentioning

confidence: 72%

“…The biocompatibility of SIBS most likely is related to a thin (10 nm) layer of pure polyisobutylene covering the polymer surface contacting with biological tissues, while the polystyrene phases are buried within the material [57]. High biocompatibility of SIBS and Gore-tex TM has recently been confirmed in the experimental and clinical studies [48,58].…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

et al. 2019

View full text Add to dashboard Cite

Superior polymers represent a promising alternative to mechanical and biological materials commonly used for manufacturing artificial heart valves. The study is aimed at assessing poly(styrene-block-isobutylene-block-styrene) (SIBS) properties and comparing them with polytetrafluoroethylene (Gore-texTM, a reference sample). Surface topography of both materials was evaluated with scanning electron microscopy and atomic force microscopy. The mechanical properties were measured under uniaxial tension. The water contact angle was estimated to evaluate hydrophilicity/hydrophobicity of the study samples. Materials’ hemocompatibility was evaluated using cell lines (Ea.hy 926), donor blood, and in vivo. SIBS possess a regular surface relief. It is hydrophobic and has lower strength as compared to Gore-texTM (3.51 MPa vs. 13.2/23.8 MPa). SIBS and Gore-texTM have similar hemocompatibility (hemolysis, adhesion, and platelet aggregation). The subcutaneous rat implantation reports that SIBS has a lower tendency towards calcification (0.39 mg/g) compared with Gore-texTM (1.29 mg/g). SIBS is a highly hemocompatible material with a promising potential for manufacturing heart valve leaflets, but its mechanical properties require further improvements. The possible options include the reinforcement with nanofillers and introductions of new chains in its structure.

show abstract

Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 94%

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Patients were evaluated preoperatively with routine controls, including baseline values of haematology; SIS-ECM was used in selected patients with CHDs in whom regenerative potential was considered highly desirable so as to decrease, or at least delay, the probability for reoperation. The use of the SIS-ECM scaffold was categorized into four major groups: A, valve repair, when SIS-ECM was used as a material to reconstruct valve leaflets, according to different techniques, including aortic leaflet extension [10] and leaflet augmentation ( Fig. 1A), or pulmonary valve (PV) reconstruction (Fig.…”

Section: Methodsmentioning

confidence: 99%

Early and mid-term clinical experience with extracellular matrix scaffold for congenital cardiac and vascular reconstructive surgery: a multicentric Italian study

Padalino

Quarti

Angeli

et al. 2015

Interact CardioVasc Thorac Surg

View full text Add to dashboard Cite

show abstract

“…Autologous fresh pericardium retracts with time, while glutaraldehyde-fixed pericardium calcifies [37]. Expanded polytetrafluoroethylene has been proposed as a leaflet repair patch material [38], however mid- and long-term follow-up data is still pending and this material may be at risk of calcification [39] or late fracture [40]. Each of these materials are permanent, non-degradable and at risk of seeding and the cause of recurrent infection.…”

Section: Discussionmentioning

confidence: 99%

Biodegradable materials for surgical management of infective endocarditis: new solution or a dead end street?

2014

View full text Add to dashboard Cite

BackgroundOne third of patients with infective endocarditis will require operative intervention. Given the superiority of valve repair over valve replacement in many indications other than endocarditis, there has been increasing interest and an increasing number of reports of excellent results of valve repair in acute infective endocarditis. The theoretically ideal material for valve repair in this setting is non-permanent, “vanishing” material, not at risk of seeding or colonization. The goal of this contribution is to review currently available data on biodegradable materials for valve repair in infective endocarditis.DiscussionRigorous electronic and manual literature searches were conducted to identify reports of biodegradable materials for valve repair in infective endocarditis. Articles were identified in electronic database searches of Medline, Embase and the Cochrane Library, using a predetermined search strategy. 49 manuscripts were included in the review. Prosthetic materials needed for valve repair can be summarized into annuloplasty rings to remodel the mitral or tricuspid annulus, and patch materials to replace resected valvar tissue. The commercially available biodegradable annuloplasty ring has shown interesting clinical results in a single-center experience; however further data is required for validation and longer follow-up. Unmodified extra-cellular matrix patches, such as small intestinal submucosa, have had promising initial experimental and clinical results in non-infected valve repair, although in valve repair for endocarditis has been reported in only one patient, and concerns have been raised regarding their mechanical stability in an infected field.SummaryThese evolving biodegradable devices offer the potential for valve repair with degradable materials replaced with autologous tissue, which could further improve the results of valve repair for infective endocarditis. This is an evolving field with promising experimental or initial clinical results, however long-term outcomes are lacking and further data is necessary to validate this theoretically interesting approach to infective endocarditis.

show abstract

Initial experience with polytetrafluoroethylene leaflet extensions for aortic valve repair

Abstract: The use of PTFE leaflet extensions is an effective technique for aortic valve reconstruction in congenital valvular disease. Long-term follow-up is necessary to assess the durability of this type of repair.

Cited by 28 publications

References 19 publications

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

Polyisobutylene-Based Thermoplastic Elastomers for Manufacturing Polymeric Heart Valve Leaflets: In Vitro and In Vivo Results

Early and mid-term clinical experience with extracellular matrix scaffold for congenital cardiac and vascular reconstructive surgery: a multicentric Italian study

Biodegradable materials for surgical management of infective endocarditis: new solution or a dead end street?

Contact Info

Product

Resources

About