Inhibitory effects of the root extract of Dipsacus asperoides C.Y. Cheng et al T.M.Ai on collagen-induced arthritis in mice

Jung, Hyo Won; Jung, Jin Ki; Son, Kun Ho; Lee, Dong Hwa; Kang, Tae Min; Kim, Young Shik; Park, Yong‐Ki

doi:10.1016/j.jep.2011.10.020

Cited by 40 publications

(18 citation statements)

References 23 publications

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“…The effective concentrations of XD for cell behavior were determined in several previous studies [22,25,40]. XD was verified to have adverse effects on hard tissue regeneration in mice at concentrations higher than 50 mg/kg [41]. Recently, Yao et al showed 10 μg/mL of XD immobilized on bioceramic had the ability to promote new hard tissue formation [27].…”

Section: Resultsmentioning

confidence: 99%

Poly(Dopamine)-Assisted Immobilization of Xu Duan on 3D Printed Poly(Lactic Acid) Scaffolds to Up-Regulate Osteogenic and Angiogenic Markers of Bone Marrow Stem Cells

et al. 2015

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Three-dimensional printing is a versatile technique to generate large quantities of a wide variety of shapes and sizes of polymer. The aim of this study is to develop functionalized 3D printed poly(lactic acid) (PLA) scaffolds and use a mussel-inspired surface coating and Xu Duan (XD) immobilization to regulate cell adhesion, proliferation and differentiation of human bone-marrow mesenchymal stem cells (hBMSCs). We prepared PLA scaffolds and coated with polydopamine (PDA). The chemical composition and surface properties of PLA/PDA/XD were characterized by XPS. PLA/PDA/XD controlled hBMSCs’ responses in several ways. Firstly, adhesion and proliferation of hBMSCs cultured on PLA/PDA/XD were significantly enhanced relative to those on PLA. In addition, the focal adhesion kinase (FAK) expression of cells was increased and promoted cell attachment depended on the XD content. In osteogenesis assay, the osteogenesis markers of hBMSCs cultured on PLA/PDA/XD were significantly higher than seen in those cultured on a pure PLA/PDA scaffolds. Moreover, hBMSCs cultured on PLA/PDA/XD showed up-regulation of the ang-1 and vWF proteins associated with angiogenic differentiation. Our results demonstrate that the bio-inspired coating synthetic PLA polymer can be used as a simple technique to render the surfaces of synthetic scaffolds active, thus enabling them to direct the specific responses of hBMSCs.

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Section: Resultsmentioning

confidence: 99%

Poly(Dopamine)-Assisted Immobilization of Xu Duan on 3D Printed Poly(Lactic Acid) Scaffolds to Up-Regulate Osteogenic and Angiogenic Markers of Bone Marrow Stem Cells

et al. 2015

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“…Medicinal plants and their extracts have long been used as therapeutic agents for arthritis treatment in the traditional systems of medicine in many parts of the world [118–124]. In addition, medicinal plants have served as the source of several biologically active compounds that have formed the basis of development of new drugs by pharmaceutical companies.…”

Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

“…In addition, it decreased the production of lipid peroxides (LPO) but increased the production of superoxide dismutase (SOD) and glutathione (GSH) in cartilage tissue [124]. (6) A water-extract of Dipsaci radix (DR), the dried root of Dipsacus asperoides , significantly suppressed the arthritic scores and serum levels of anti-CII IgG2a antibody, PGE(2), TNF- α , IL-1 β , and IL-6 in mice with CIA [118]. (7) Similarly, Morus bombycis Koidzumi (MB) extract significantly decreased the clinical arthritis index and suppressed the expression of cytokines (TNF- α , IL-1 β , IL-6), chemokines (MIP-1 α , RANTES), and MMPs (MMP-1, MMP-3) in mice with CIA [119].…”

Section: Herbal Products Used To Treat or Prevent Arthritismentioning

confidence: 99%

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Nanjundaiah

Astry

Moudgil

2013

Evidence-Based Complementary and Alternative Medicine

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Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints leading to bone and cartilage damage. Untreated inflammatory arthritis can result in severe deformities and disability. The use of anti-inflammatory agents and biologics has been the mainstay of treatment of RA. However, the prolonged use of such agents may lead to severe adverse reactions. In addition, many of these drugs are quite expensive. These limitations have necessitated the search for newer therapeutic agents for RA. Natural plant products offer a promising resource for potential antiarthritic agents. We describe here the cellular and soluble mediators of inflammation-induced bone damage (osteoimmunology) in arthritis. We also elaborate upon various herbal products that possess antiarthritic activity, particularly mentioning the specific target molecules. As the use of natural product supplements by RA patients is increasing, this paper presents timely and useful information about the mechanism of action of promising herbal products that can inhibit the progression of inflammation and bone damage in the course of arthritis.

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“…Most previous studies of D. asperoides have focused on germplasm resources (Chen and Ai, 1997), traditional morphological classifications (Li et al, 1993;Feng et al, 2000), chemicals (Liu et al, 2011), and pharmacological applications (Jung et al, 2012). Basic studies of the genetic structure of different populations using molecular markers have not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity and population structure of wild Dipsacus asperoides in China as indicated by ISSR markers

Chen¹,

Li²,

Zhang³

et al. 2014

Genet. Mol. Res.

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ABSTRACT. In order to evaluate the genetic diversity and genetic structure of wild Dipsacus asperoides, we surveyed genetic polymorphisms in 288 individuals from 12 populations using ISSR. A total of 240 bands were amplified, among which 190 were polymorphic loci. At the species level, genetic diversity was found to be abundant: PPB = 79.17%, N E = 1.2152, H = 0.1361, and H sp = 0.2213. At the population level, genetic diversity was lower: PPB = 30.76 %, N E = 1.0786, H = 0.0897, and H pop = 0.1375. The calculated Nei genetic differentiation coefficient was 0.3406, which is consistent with the calculated Shannon population genetic differentiation coefficient of 0.3787. This is commonly taken to indicate that most of the genetic variation existed within the populations. Gene flow was calculated as N m = 0.9679, suggesting that gene exchange only occurred at a low level. Based on the Nei genetic distance, the 12 populations were divided into 4 categories. Our results suggest that D. asperoides has 6341 Genetic diversity in wild Dipsacus asperoides ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 13 (3): 6340-6349 (2014) abundant genetic diversity and provides a foundation for the protection and improvement of germplasm resources.

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Inhibitory effects of the root extract of Dipsacus asperoides C.Y. Cheng et al T.M.Ai on collagen-induced arthritis in mice

Cited by 40 publications

References 23 publications

Poly(Dopamine)-Assisted Immobilization of Xu Duan on 3D Printed Poly(Lactic Acid) Scaffolds to Up-Regulate Osteogenic and Angiogenic Markers of Bone Marrow Stem Cells

Poly(Dopamine)-Assisted Immobilization of Xu Duan on 3D Printed Poly(Lactic Acid) Scaffolds to Up-Regulate Osteogenic and Angiogenic Markers of Bone Marrow Stem Cells

Mediators of Inflammation-Induced Bone Damage in Arthritis and Their Control by Herbal Products

Genetic diversity and population structure of wild Dipsacus asperoides in China as indicated by ISSR markers

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