Inhibitory effects ofCymodocea nodosasulphated polysaccharide onα-amylase activity, liver-kidney toxicities and lipid profile disorders in diabetic rats

Abstract

This study aimed to evaluate for the first time the effects of Cymodocea nodosa sulphated polysaccharide (CNSP) on the α-amylase activity, hyperglycaemia, liver-kidney functions, and pancreatic architecture of alloxan-induced diabetic rats. Animals were allocated into four groups of seven rats each, the body weight and blood glucose levels were estimated periodically for 2 months of treatment by gastric gavages route. The CNSP effect was confirmed by biochemical procedures and histological study. The inhibition of α-amylase activity and protection of pancreatic β-cells induced a decrease in the blood glucose levels and regulated the lipid profile in the plasma of the treated diabetic rats, which helped to maintain the homeostasis of blood lipid. Moreover, CNSP administration induced a significant decrease in the levels of lipid peroxidation in the pancreas, liver and kidney of diabetic rats and protects their functions attested by a decrease in the levels of toxicity parameters in blood.

Phytochemical Screening and Antidiabetic, Antihyperlipidemic, and Antioxidant Properties of Anthyllis henoniana (Coss.) Flowers Extracts in an Alloxan‐Induced Rats Model of Diabetes

“…According to Kolsi et al [ 30 ], this test demonstrates the capacity to reply suitably to a glucose challenge. Oral glucose tolerance test was performed in control and treated rats groups, 24 h before their decapitation.…”

Hypoglycaemic Molecules for the Management of Diabetes Mellitus from Marine Sources

“…Sulphated polysaccharide isolated from Cymodocea nodosa (CNSP) inhibited α-amylase activity and reduced the blood glucose level by protecting pancreatic β-cells. 90 It can also increase the insulin secretion in the blood, leading to improved metabolism and body weight. 90 In addition, CNSP also prevents the conversion of starch to simple sugars by inhibiting the enzyme responsible in the conversion process.…”

A Review on Futuristic Scope of Agents Related to Amphibian’s Skin and Plants-based Sources in Type 2 Antidiabetic Therapies

“…Moreover, the extract has also shown to reduce the body weight while inhibiting the lipase activity in obese high fed rats leading to decreased triglycerides levels, low density lipoproteins (LDL), total cholesterol level and rise in high density lipoprotein cholesterol (HDL) and maintaining blood lipid homeostasis. [108][109][110]…”