Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression

Matheus, Maria Eline; Fernandes, Sidnei Bessa de Oliveira; Silveira, Carla Semiramis; Rodrigues, Verônica Pinto; Menezes, Fábio de Sousa; Fernandes, Patrícia Dias

doi:10.1016/j.jep.2006.03.010

Cited by 65 publications

(29 citation statements)

References 23 publications

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“…The Euterpe oleracea Mart. extracts were also able to inhibit the production of nitric oxide and iNOS expression from culture cells (Matheus et al, 2006). This effect appears to be a consequence of direct action of the extract on the biosynthesis of NO, which has several physiologic activities, such as vasodilation, tumoricid and cytotoxic activities.…”

Section: Introductionmentioning

confidence: 87%

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Favacho¹,

Oliveira²,

Santos³

et al. 2011

Rev. bras. farmacogn.

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Abstract:The oil of the fruits of Euterpe oleracea Mart., Arecaceae (OEO), was evaluated in models of inflammation and hyperalgesia in vivo to study its effects on these conditions. The experimental models contained the writhing test in mice, rat paw edema, granuloma test in rats, vascular permeability in rats, cell migration to the peritoneal cavity in rats and ear erythema induced by croton oil in mice. Doses of 500, 1000 and 1500 mg/kg of OEO were administered orally. The observed number of writhes was inhibited by 33.67, 45.88 and 55.58%, respectively. OEO produced a dose-dependent effect, with linear correlation coefficient R=0.99 (y=0.0219x+23.133), and the median effective dose found was 1226.8 mg/kg. The oral administration of 1226.8 mg/kg of OEO inhibited carrageenan-induced edema by 29.18% (p<0.05) when compared to the control group. The daily administration of OEO for six days inhibited the formation of granulomatous tissue by 36.66% (p<0.01). In ear erythema induced by croton oil, OEO presented a significant inhibition (37.9%). In the vascular permeability test, treatment with OEO decreased the response to histamine, inhibiting vascular permeability by 54.16%. In carrageenan-induced peritonitis, OEO reduced the number of neutrophils migrating compared to the control group by 80.14%. These results suggested that OEO has anti-inflammatory and antinociceptive activities, probably of peripheral origin and linked to prostaglandin biosynthesis inhibition.

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Section: Introductionmentioning

confidence: 87%

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Favacho¹,

Oliveira²,

Santos³

et al. 2011

Rev. bras. farmacogn.

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“…The extracts of this species were able to inhibit nitric oxide production and iNOS expression from cell culture (Matheus et al, 2003;Matheus et al, 2006). Among these biological evaluations, antioxidant effects have been the most frequently investigated and the key constituents have been described.…”

Section: E Oleracea Pulp: Cell Assaysmentioning

confidence: 99%

Amazon acai: Chemistry and biological activities: A review

et al. 2015

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“…The anti-inflammatory activity caused by the inhibitory effects on nitric oxide (NO) production by activated macrophage cell was reported by Matheus et al, (2006). The oral contrast agent used in magnetic resonance imaging and the vasodilator effect have been reported (Córdova-Fraga et al, 2004;Rocha et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Multiple emulsions containing amazon oil: açaí oil (Euterpe oleracea)

Ferrari¹,

Rocha‐Filho

2011

Rev. bras. farmacogn.

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Abstract:The aim of this work was to formulate O/W/O multiple emulsions containing açaí oil as a model system and to evaluate their physical stability and in vivo Sun Protection Factor (SPF). Multiple emulsions are complex dispersion systems, known also as, "emulsions of emulsions". These emulsion systems, have significant potential in the cosmetic industry. Euterpe oleracea Mart., Arecaceae, popularly known in Brazil as "açaí", is an economically important plant. Açaí oil has been used as antioxidant and as anti-inflammatory activities. The multiple emulsions were prepared using a two-step procedure. The investigated formulations were characterized and their stability over time was evaluated by preliminary and accelerated stability. O/W/O multiple emulsions containing the same concentration of sunscreens with and without açaí oil were evaluated by the International Sun Protection Factor Test Method. The samples containing 70% (w/w) of primary emulsion, 5% (w/w) PEG-30-dipolyhydroxystearate, 10% (w/w) of açaí oil and 5% (w/w) of sucrose polybehenate have been found to be stable. The rheological measurements revealed that the samples exhibited non-Newtonian pseudoplastic flow behavior and thixotropy. To conclude, no statistical difference could be observed on the in vivo SPF to both multiple systems with or without açaí oil.

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Inhibitory effects of Euterpe oleracea Mart. on nitric oxide production and iNOS expression

Cited by 65 publications

References 23 publications

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Anti-inflammatory and antinociceptive activities of Euterpe oleracea Mart., Arecaceae, oil

Amazon acai: Chemistry and biological activities: A review

Multiple emulsions containing amazon oil: açaí oil (Euterpe oleracea)

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