Inhibitory Effects of Curcumin on the Expression of NorA Efflux Pump and Reduce Antibiotic Resistance in Staphylococcus aureus

Antibacterial activity of curcumin and its essential nanoformulations against some clinically important bacterial pathogens: A comprehensive review

“…In connection to this, Joshi et al 95 . showed that curcumin (25 μM) and osthol had high potential to block the Nor A efflux pump of S. aureus , thereby retarding S. aureus multidrug resistance and increasing susceptibility to antimicrobial molecule 96 . Bacterial efflux pump being an important target, extensive and rigorous research may be carried out with various other important and potential phytocompounds that can bind and inhibit the known bacterial efflux pumps.…”

“…In a nutshell and precisely, it can be inferred that nanocurcumin/nanocomposites and curcumin exhibit efficient anti‐ P. aeruginosa and antibiofilm activity by inhibiting the QS system, retarding release of components for biofilm formation, biofilm disruption, ROS‐mediated bacterial membrane, and ultrastructure damage 51–66,71–78 . Similarly, MRSA and MDR‐ S. aureus growth and biofilm can be effectively inhibited with nanocurcumin/nanocomposites and curcumin along with antibiotics, blue light‐mediated PDI, cell penetrating peptide, and so on, that generate singlet oxygen and other ROS, thereby causing bacterial membrane damage and cytoplasmic leakage 79–102 . Curcumin nanocomplex aerosols and crude curcumin (along with blue LED light‐activated EDTA) have the potential to inhibit B. cepacia growth by mechanism that includes bacterial DNA and protein damage and intracellular content leakage 103–109 .…”