Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities

Zheng, Yin; Bae, Soo Hyeon; Kwon, Min Jo; Park, Jung Bae; Choi, Hye Duck; Shin, Wonjae; Bae, Soo Kyung

doi:10.1016/j.fct.2013.04.053

Cited by 46 publications

(25 citation statements)

References 28 publications

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“…2 and 3. The IC 50 s for the positive controls used in the reversible inhibition studies were in good agreement with published values to an acceptable degree of accuracy (19,30,31).…”

Section: Resultssupporting

confidence: 84%

Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro

Bae

Kwon

Park

et al. 2014

Antimicrob Agents Chemother

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“…2 and 3. The IC 50 s for the positive controls used in the reversible inhibition studies were in good agreement with published values to an acceptable degree of accuracy (19,30,31).…”

Section: Resultssupporting

confidence: 84%

Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro

Bae

Kwon

Park

et al. 2014

Antimicrob Agents Chemother

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“…SP contains c-linolenic acid, [37][38][39][40] tocopherols, 41 and carotenoids such as b-carotene 40 and lutein. 42 It has also been shown that C-phycocyanin (C-PC), a bioactive pigment in SP that has potent antioxidant and antiinflammatory properties, protects liver from inflammation by inhibiting oxidation-induced NF-jB activation in Kupffer cells. 43 These compounds in SP may be responsible for the atheroprotective effect by exerting antioxidant and antiinflammatory effects, as mounting evidence supports that inhibition of inflammation and oxidative stress can prevent atherosclerosis.…”

Section: Discussionmentioning

confidence: 99%

Blue-Green Algae Inhibit the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

Kim

Pham

et al. 2015

Journal of Medicinal Food

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Hyperlipidemia and inflammation contribute to the development of atherosclerotic lesions. Our objective was to determine antiatherogenic effect of edible blue-green algae (BGA) species, that is, Nostoc commune var. sphaeroides Kützing (NO) and Spirulina platensis (SP), in apolipoprotein E knockout (ApoE(-/-)) mice, a well-established mouse model of atherosclerosis. Male ApoE(-/-) mice were fed a high-fat/high-cholesterol (HF/HC, 15% fat and 0.2% cholesterol by wt) control diet or a HF/HC diet supplemented with 5% (w/w) of NO or SP powder for 12 weeks. Plasma total cholesterol (TC) and triglycerides (TG) were measured, and livers were analyzed for histology and gene expression. Morphometric analysis for lesions and immunohistochemical analysis for CD68 were conducted in the aorta and the aortic root. NO supplementation significantly decreased plasma TC and TG, and liver TC, compared to control and SP groups. In the livers of NO-fed mice, less lipid droplets were present with a concomitant decrease in fatty acid synthase protein levels than the other groups. There was a significant increase in hepatic low-density lipoprotein receptor protein levels in SP-supplemented mice than in control and NO groups. Quantification of aortic lesions by en face analysis demonstrated that both NO and SP decreased aortic lesion development to a similar degree compared with control. While lesions in the aortic root were not significantly different between groups, the CD68-stained area in the aortic root was significantly lowered in BGA-fed mice than controls. In conclusion, both NO and SP supplementation decreased the development of atherosclerotic lesions, suggesting that they may be used as a natural product for atheroprotection.

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“…There are few reports about interactions between drugmetabolising enzymes and astaxanthin, b-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin. 5 the aim of the present study was to find the effect of lutein isolated from Tagetes erecta L on cytochrome P450 isoform CYP3A4.…”

Section: Introductionmentioning

confidence: 99%

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

Meenapriya¹,

Anitha²,

Lakshmi³

2018

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Background: Lutein is a carotenoids vitamin rich in many fruits and vegetables and also available in multivitamin products. It is consumed for its effect on eye disease, cancer, diabetes and other health conditions. Recently, herbal preparations are increasingly used in healthcare systems and concomitant administration of synthetic medications may cause pharmacokinetic or pharmacodynamic interactions leading to very serious medical problems. Understanding the ability of herbal extracts and preparations to modulate the metabolizing enzymes can help the health system for proper treatment of patients and thereby can avoid many adverse effects associated with it. The aim of the study was to find the effect of lutein isolated from Tagetes erecta L on cytochrome P450 isoform CYP3A4. Materials and Methods: The different concentrations of lutein (5-100µg/ml), potassium phosphate buffer, CYP450 reagent and substrate 7-Benzyloxy-4-trifluoromethylcoumarin (BFC) were added to a 96-well plate. The fluorescent intensities of the products were measured by Perkin Elmer Enspire fluorescence reader using an excitation and emission wavelength of 405 nm and 460 nm, respectively to examine the effect of lutein on Cytochrome P 450 isoform CYP3A4 and the IC 50 was calculated by plotting concentrations of lutein against the corresponding percent inhibition. Results: All the tested concentrations of lutein showed potent inhibition against CYP3A4 in a dose-dependent manner. The IC 50 value was found to be 35.27µg/ml. Conclusion: The inhibitory effect of lutein indicates the possibilities of herb-drug interaction if it is co-administered with prescribed drugs that are normally metabolised by CYP3A4 enzyme.

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Inhibitory effects of astaxanthin, β-cryptoxanthin, canthaxanthin, lutein, and zeaxanthin on cytochrome P450 enzyme activities

Cited by 46 publications

References 28 publications

Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro

Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro

Blue-Green Algae Inhibit the Development of Atherosclerotic Lesions in Apolipoprotein E Knockout Mice

Effect of Lutein on Cytochrome P450 (Isoform CYP3A4) - An in vitro Study

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