Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo

Chathuranga, Kiramage; Weerawardhana, Asela; Dodantenna, Niranjan; Ranathunga, Lakmal; Cho, Won‐Kyung; Yeul, Jin; Lee, Jong-Soo

doi:10.3390/v13040548

Cited by 15 publications

(6 citation statements)

References 51 publications

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“…Plain-NE was also examined, showing IC 50 values of 45.24 μg/mL against HAV and 42.11 μg/mL against HSV-1. Several constituents in the chemical composition of both EOs were reported to have antiviral activity, such as linalool [ 41 ], nerolidol [ 42 ], and straight chain hydrocarbon compounds (acyclic alkanes) e.g., tetracosane [ 43 ], and nonacosane [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

Nanoemulsions of Jasminum humile L. and Jasminum grandiflorum L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects

et al. 2022

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Unprecedented nanoemulsion formulations (NE) of Jasminum humile and Jasminum grandiflorum essential oils (EO) were prepared, and examined for their cytotoxic and antiviral activities. NE characterization and stability examination tests were performed to ensure formula stability. The antiviral activity was determined against hepatitis A (HAV) and herpes simplex type-1 (HSV-1) viruses using MTT assay, while the cytotoxic potential was determined against liver (HepG-2), breast (MCF-7), leukemia (THP-1) cancer cell lines and normal Vero cells. Statistical significance was determined in comparison with doxorubicin as cytotoxic and acyclovir as antiviral standard drugs. GC-MS analysis indicated twenty four compounds in the EO of J. humile and seventeen compounds in the EO of J. grandiflorum. Biological investigations of pure EOs revealed weak cytotoxic and antiviral effects. Nevertheless, their NE formulations exhibited high biological value as cytotoxic and antiviral agents. NE formulations also showed feasible selectivity index for the viral-infected and cancer cells (especially HepG-2) than normal Vero cells. Both nanoemulsions showed lower IC50 than standard doxorubicin against HepG-2 (26.65 and 22.58 vs. 33.96 μg/mL) and MCF-7 (36.09 and 36.19 vs. 52.73 μg/mL), respectively. The study results showed the dramatic effect of nanoemulsion preparation on the biological activity of EOs and other liposoluble phytopharmaceuticals.

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Section: Resultsmentioning

confidence: 99%

Nanoemulsions of Jasminum humile L. and Jasminum grandiflorum L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects

et al. 2022

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“…Moreover, it has also exhibited antiviral activity (Sun et al, 2021). A previous study demonstrated that treatment of HEp2 cells with S. fusiforme extracts in non-cytotoxic concentrations could led to an obvious decrease of respiratory syncytial virus (RSV) replication, RSV gene transcription, RSV protein synthesis, RSV-induced cell death, and syncytium formation (Chathuranga et al, 2021). Sun et al also reported that, upon treatment with S. fusiforme extracts, the gene and protein expressions of the avian leukosis virus subgroup J (ALV-J) were clearly reduced (Sun et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

Study on the Anti-Adenovirus Mechanism of Sargassum fusiforme

Feng

Zhang

Peng

et al. 2022

Front. Cell. Infect. Microbiol.

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Human adenovirus (HAdV) has a worldwide distribution and remains a major pathogen that leads to infections of the respiratory tract. No specific treatments or vaccines are yet available for HAdV infection. Sargassum fusiforme, an edible seaweed, has attracted a lot of attention for its various bioactivities. S. fusiforme has been reported to exhibit antiviral activity. However, research studies about its anti-HAdV activity are few. In this research, we found that S. fusiforme had low cytotoxicity and possessed anti-human adenovirus type 7 (HAdV7) activity in vitro, and the most effective ingredient was alginate. The time of addition assay demonstrated inhibitory effects that were observed in all life stages of the virus. In addition, we observed that the antiviral activity of alginate against HAdV7 infection might be closely related to the endoplasmic reticulum stress (ERS) pathway. Taken together, these results suggest that S. fusiforme extracts have potential application in the prevention and treatment of HAdV infection.

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“…In some research studies, chemical components in S. fusiforme also showed antiviral and antibacterial effects. ,,− Ahmed et al obtained crude extracts of different solvents ( n -hexane, ethyl acetate, and ethanol) from S. fusiforme , and extracted flavonoids and alkaloids. They used a well diffusion assay to detect the effects of the obtained substances on bacterial pathogens inflicting gross lesions in corals (such as Vibrio owensii , Emperobacter brevis , Provincia vermica , and Brevibacterium linens ) .…”

Section: Bioactivities Of S Fusiformementioning

confidence: 99%

Bioactivities of the Popular Edible Brown Seaweed Sargassum fusiforme: A Review

Wang,

Huang,

et al. 2023

J. Agric. Food Chem.

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Sargassum fusiforme has a wide range of active constituents (such as polysaccharides, sterols, polyphenols, terpenes, amino acids, trace elements, etc.) and is an economically important brown algae with a long history. In recent years, S. fusiforme has been intensively studied and has attracted wide attention in the fields of agriculture, environment, medicine, and functional food. In this review, we reviewed the current research status of S. fusiforme at home and abroad over the past decade by searching Web of science, Google Scholar, and other databases, and structurally analyzed the active components of S. fusiforme, and on this basis, we focused on summarizing the cutting-edge research and scientific issues on the role of various active substances in S. fusiforme in exerting antioxidant, anti-inflammatory, antitumor, antidiabetic, immunomodulatory, antiviral antibacterial, and anticoagulant effects. The mechanisms by which different substances exert active effects were further summarized by exploring different experimental models and are shown visually. It provides a reference to promote further development and comprehensive utilization of S. fusiforme resources.

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Inhibitory Effect of Sargassum fusiforme and Its Components on Replication of Respiratory Syncytial Virus In Vitro and In Vivo

Cited by 15 publications

References 51 publications

Nanoemulsions of Jasminum humile L. and Jasminum grandiflorum L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects

Nanoemulsions of Jasminum humile L. and Jasminum grandiflorum L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects

Study on the Anti-Adenovirus Mechanism of Sargassum fusiforme

Bioactivities of the Popular Edible Brown Seaweed Sargassum fusiforme: A Review

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