Inhibitory effect of Ruta graveolens L. on oxidative damage, inflammation and aortic pathology in hypercholesteromic rats

Ratheesh, M.; Shyni, G. L.; Sindhu, Ganapathy; Helen, A.

doi:10.1016/j.etp.2010.01.007

Cited by 32 publications

(21 citation statements)

References 41 publications

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“…These evidences demonstrate that hypercholesterolemia contributes to atherogenesis development in this rat model. These findings are in agreement with previous reports (12,18,19), which showed that elevated total cholesterol and LDLcholesterol levels promote oxidative damage and inflammation and impair endothelial function. The treatment with LASSBio-788 promoted a significant decrease in the lipid parameters evaluated and promoted an increase of HDL-cholesterol (Table 1).…”

Section: Discussionsupporting

confidence: 83%

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

et al. 2013

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Abstract. The compound LASSBio-788 (N-Allyl (2-thienylidene) 3,4-methylenedioxybenzoylhydrazine) is a thienylacylhydrazone derivative shown to have antiplatelet, vasodilatory, and antiinflammatory properties in vitro. We hypothesize that LASSBio-788 may exert beneficial effects on atherosclerosis. Male wistar rats were divided into 4 groups: Control group received standard rat chow, hypercholesterolemic group (HC) and HC+788 (compound LASSBio-788 group) received hypercholesterolemic diet for 45 days. HC+788 group received compound LASSBio-788 (100 mmol/kg) once daily in the last 15 days. LASSBio-788 reduced the levels of total cholesterol (109.1 ± 4.3 vs. 361.0 ± 12.8 mg/dl), triglycerides (66.1 ± 1.1 vs. 186.9 ± 17.7 mg/dl), LDLc (63.2 ± 6.1 vs. 330.9 ± 9.7 mg/dl), VLDLc (9.8 ± 1.1 vs. 45.0 ± 4.6 mg/dl) and malondialdehyde (4.8 ± 0.3 vs. 9.4 ± 0.5 nmol/ml) compared to the HC group. LASSBio-788 presented antiplatelet properties and decreased inflammatory markers levels. LASSBio-788 promoted a decrease in contractile response to phenylephrine and an improvement in endothelium-dependent vasorelaxant response by increasing two-fold the expression of nitric oxide synthase (eNOS). Our results suggest that the compound LASSBio-788 represents a new multi-targeted drug candidate for the treatment of atherosclerosis.

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Section: Discussionsupporting

confidence: 83%

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

et al. 2013

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“…As a result, enhancing the activities of the antioxidant enzymes is useful to prevent the renal injury induced by ROS (PedrazaChaverrí et al, 2004). Some polyphenols and flavonoids (such as naringenin and quercetin) are reported to have the potential effect of enhancing the activities of antioxidant enzymes such as superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) (Vitor et al, 2004;Ratheesh et al, 2011), and finally attenuating the nephrotoxicity in streptozotocin-induced diabetic rats (Sato et al, 2005). Puromycin aminonucleoside (PAN) is usually used to induce the experimental chronic NS which involves the imbalance of the generation and elimination of ROS (Pedraza-Chaverrí et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Chen

Lei

et al. 2012

Journal of Ethnopharmacology

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“…(Conway & Slocumb, 1979). Ruta graveolens showed an anti-inflammatory effect against adjuvant-induced arthritis (Ratheesh et al, 2009(Ratheesh et al, , 2011. The plant contains more than 120 compounds of different classes of natural products such as acridone alkaloids, coumarins, essential oils, flavonoids and furoquinolines (Kuzovkina et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Oral administration of alkaloid fraction fromRuta graveolensinhibits oxidative stress and inflammation in hypercholesterolemic rabbits

Ratheesh

Helen

2013

Pharmaceutical Biology

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Context: The anti-atherogenic effect of alkaloid fraction from Ruta graveolens Linn (Rutaceae) extract is suspected to be related to its activities of antioxidation and antiinflammation.Objective: This study investigated the efficacy of alkaloid fraction isolated from Ruta graveolens (AFR) in reducing oxidative damage and inflammation in hypercholesteremic rabbits. Materials and methods: The New Zealand white rabbits were randomly divided into three groups: Group I rabbits were fed with normal chow diet for 90 d. Group II rabbits were fed with 1% cholesterol-enriched diet. Group III rabbits were fed with 1% cholesterol-enriched diet together with AFR (10 mg/kg/daily for 90 d).Results and discussion: The results showed that on treatment with AFR significantly lowered the level of total cholesterol and LDL-C and showed an increment in the level of HDL-C. LD 50 of the AFR in rats is greater than 525 mg/kg. Activities of antioxidant enzymes such as superoxide dismutase, catalase and glutathione peroxidase and GSH level were decreased in cholesterol-fed rabbit and supplementation of AFR significantly enhanced the activities of these antioxidant enzymes and GSH level. Increased activities of enzymes such as cyclooxygenase-2, 15-lipoxygenase and myeloperoxidase were significantly suppressed by AFR administration. The acute phase proteins, total WBC count and TBARS concentrations were significantly increased by hypercholesteromic diet, which were significantly decreased by AFR treatment. Histopathological studies of aorta in cholesterol-fed rabbit showed plaque formation and significant changes in aortic wall. Administration of AFR showed no changes in aortic wall. Conclusion: AFR reduces oxidative stress and inflammation and reduces the aortic pathology in hypercholesteromic rabbits.

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Inhibitory effect of Ruta graveolens L. on oxidative damage, inflammation and aortic pathology in hypercholesteromic rats

Cited by 32 publications

References 41 publications

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

Anti-atherogenic Effects of a New Thienylacylhydrazone Derivative, LASSBio-788, in Rats Fed a Hypercholesterolemic Diet

Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Oral administration of alkaloid fraction fromRuta graveolensinhibits oxidative stress and inflammation in hypercholesterolemic rabbits

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