Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Chen, Jinglou; Lei, Yongfang; Wu, Guanghua; Zhang, Yonghui; Fu, Wei; Xiong, Chaomei; Ruan, Jinlan

doi:10.1016/j.jep.2011.11.002

Cited by 8 publications

(8 citation statements)

References 39 publications

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“…( Thelypteridaceae ), a fern that is widespread throughout South Africa and Madagascar, tropical and subtropical Asia, Australia and New Zealand, and has also been introduced to North and South America. It is grown as a vegetable or folk medicine (Chang et al ., ; Chen et al ., ). The cytotoxic flavonoids found by Lin et al .…”

Section: Anticancer Activity Of Extracts and Compounds Isolated From mentioning

confidence: 99%

Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Tomšík

2013

Phytotherapy Research

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Many species of seedless vascular plants-ferns and lycopods-have been used as food and folk medicine since ancient times. Some of them have become the focus of intensive research concerning their anticancer properties. Studies on the anticancer effect of crude extracts are being increasingly replaced by bioactivity-guided fractionation, as well as detailed assessment of the mechanism of action. Numerous compounds-especially flavonoids such as amentoflavone and protoapigenone, and also simpler phenolic compounds, steroids, alkaloids and terpenoids-were isolated and found to be cytotoxic, particularly pro-apoptotic, or to induce cell cycle arrest in cancer cell lines in vitro. In in vivo experiments, some fern-derived compounds inhibited tumour growth with little toxicity. On the other hand, many ferns-not only the well-known Bracken (Pteridium)-may pose a significant hazard to human health due to the fact that they contain carcinogenic sesquiterpenoids and their analogues. The objective of this review is to summarise the recent state of research on the anticancer properties of ferns and lycopods, with a focus on their characteristic bioactive constituents. The carcinogenic hazard posed by ferns is also mentioned.

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Section: Anticancer Activity Of Extracts and Compounds Isolated From mentioning

confidence: 99%

Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Tomšík

2013

Phytotherapy Research

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“…The aerial parts are used for treatment of fever, pain, granulation, healing and reducing odor in chronic skin ulcer and inflammation by the tribes of Pakistan, India and China. 3 It is also used in Chinese folk medicine for the treatment of edema for patient suffering from kidney problems. 3 Only few phyto chemical and pharmacological properties have been reported on this plant, including the renoprotective potential of M. torresiana via ameli orating oxidative stress and proinflammatory activities.…”

Section: Introductionmentioning

confidence: 99%

“…3 It is also used in Chinese folk medicine for the treatment of edema for patient suffering from kidney problems. 3 Only few phyto chemical and pharmacological properties have been reported on this plant, including the renoprotective potential of M. torresiana via ameli orating oxidative stress and proinflammatory activities. 3 In vitro and in vivo antitumor activities were reported by Huang et al, 2010.…”

Section: Introductionmentioning

confidence: 99%

“…3 Only few phyto chemical and pharmacological properties have been reported on this plant, including the renoprotective potential of M. torresiana via ameli orating oxidative stress and proinflammatory activities. 3 In vitro and in vivo antitumor activities were reported by Huang et al, 2010. 4 A novel flavonoid was isolated from the root and the structure was identified as 5, 7dihydroxy2(1, 2isopropyldioxy4oxocyclohex5enyl)chromen 4one, 5 along with four known flavonoids: protoapigenin, apigenin, kaempferol and quercetin.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Effects of Ethanol Extract from a Fern Species Macrothelypteris Torresiana (Gaudich) Aerial Parts

Mondal¹,

Ghosh²,

Ganapaty³

et al. 2016

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Introduction:Macrothelypteris torresiana is a species of fern native to tropical and subtropical region and belonging to family Thelypteridaceae. The present study was conducted to evaluate antipyretic, analgesic and anti-inflammatory activities of ethanol extract from Macrothelypteris torresiana aerial parts (EEMTAP) at doses of 200 and 400 mg/kg body weight, per os. Methods: Analgesic activity was evaluated against both thermal and chemical induced stimuli, which were evidenced from tail immersion, formalin induced paw licking and acetic acid induced writhing test. Antipyretic activity was performed by using the yeast induced hyperpyrexia method. Carrageenan induced rat paw edema and the cotton pellet granuloma model were selected for evaluating anti-inflammatory activities. Results: The formalin study showed that both the aphasic and tonic pain was blocked by the extract. Similarly EEMTAP significantly increased the latency period in the tail immersion test and the assessment of peripheral analgesic effect of the test drug exhibited a significant percentage inhibition in the writhings which were induced by acetic acid in mice. EEMTAP also significantly decreased the rectal temperature of the rats. Carrageenan induced rat paw edema showed that the role of EEMTAP was significant in this acute inflammation model at the tested dose level. In the sub-chronic cotton pellet granuloma model, the tested extract also significantly inhibited granuloma formation and the biochemical parameters alanine transaminase, aspartate transaminase and alkaline phosphatase in serum. Conclusion: An ethanolic extract of Macrothelypteris torresiana possesses analgesic, anti-inflammatory and antipyretic activity which may be mediated by the central and peripheral mechanisms.

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“…The species prefers wet places in mountain valleys at an altitude of 1000 m with distribution in tropical and subtropical regions including China, America, Australia, and Pacific islands (Lin et al 2013). As a reputed folk medicinal fern, its leaves and roots are widely used for fever, pain, and granulation in Southeast Asia and for kidney problems in China (Huang et al 2010;Chen et al 2012). The species is suffering different classified process including assigning to Macrothelypteris, Phegopteris, and allied genera (Smith and Cranfill 2002;He and Zhang 2012).…”

mentioning

confidence: 99%

The complete chloroplast genome of Macrothelypteris torresiana, a reputed medicinal fern (Thelypteridaceae)

Zhou

et al. 2018

Mitochondrial DNA Part B

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Macrothelypteris torresiana is a reputed medicinal fern. Its complete chloroplast genome was determined by Illumina paired-end sequencing. The genome is 151,150 bp in length with 43.1% overall Guanine+Cytosine (GC) content, which is divided into four distinct parts such as a small single copy (SSC, 21,772 bp), a large single copy (LSC, 82,422 bp), and two inverted repeats (IRs, 23,478 bp each). It contains 132 genes, including 86 protein-coding genes, eight ribosomal RNA genes, 35 tRNA genes, and three pseudogenes. Maximum likelihood (ML) tree revealed that M. torresiana was closely grouped with Christella appendiculata with 100% bootstrap value.

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Renoprotective potential of Macrothelypteris torresiana via ameliorating oxidative stress and proinflammatory cytokines

Cited by 8 publications

References 39 publications

Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Ferns and Lycopods—A Potential Treasury of Anticancer Agents but Also a Carcinogenic Hazard

Evaluation of Analgesic, Antipyretic and Anti-Inflammatory Effects of Ethanol Extract from a Fern Species Macrothelypteris Torresiana (Gaudich) Aerial Parts

The complete chloroplast genome of Macrothelypteris torresiana, a reputed medicinal fern (Thelypteridaceae)

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