Inhibitory effect of raspberry ketone on α-glucosidase: Docking simulation integrating inhibition kinetics

Xiong, Shangling; Yue, Li-Mei; Lim, Gyu Tae; Yang, Jun‐Mo; Lee, Jinhyuk; Park, Yong‐Doo

doi:10.1016/j.ijbiomac.2018.02.124

Cited by 32 publications

(15 citation statements)

References 38 publications

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“…In silico protein ligand docking simulation revealed that several key residues (ASP68, TYR71, HIS111, PHE157, PHE158, PHE177, GLN181, ASP214, THR215, ASP349, ASP408, and ARG439) of isomaltase (PDB: 3AJ7 ) interacts with the (–OH) group of raspberry ketone. Interestingly, kinetic analysis showed that the compound binds reversibly and non-competitively with α-glucosidase ( Xiong et al, 2018 ). Phenolic compound rich ethyl acetate soluble extract of mulberry fruit ( Morus alba L.) showed re-alteration of antioxidant enzyme activity like catalase, superoxide dismutase, glutathione dismutase as well as lowering of fasting blood glucose level in streptozotocin induced diabetes rats ( Wang et al, 2013 ).…”

Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

218

121

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Recently the use of bioactive α-glucosidase inhibitors for the treatment of diabetes have been proven to be the most efficient remedy for controlling postprandial hyperglycemia and its detrimental physiological complications, especially in type 2 diabetes. The carbohydrate hydrolysing enzyme, α-glucosidase, is generally competitively inhibited by the α-glucosidase inhibitors and results in the delayed glucose absorption in small intestine, ultimately controlling the postprandial hyperglycemia. Here we have reviewed the most recent updates in the bioactive α-glucosidase inhibitors category. This review provides an overview of the α-glucosidase inhibitory potentials and efficiency of controlling postprandial hyperglycemia of various bioactive compounds such as flavonoids, phenolic compound, polysaccharide, betulinic acid, tannins, anthocyanins, steroids, polyol, polyphenols, galangin, procyanidins, hydroxyl-α-sanshool, hydroxyl-β-sanshool, erythritol, ganomycin, caffeoylquinic acid, resin glycosides, saponins, avicularin, oleanolic acids, urasolic acid, ethanolic extracts etc., from various dietary and non-dietary naturally occurring sources.

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Section: Dietary Sources and Their Bioactive α-Glucosidase Inhibitorsmentioning

confidence: 99%

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Hossain

Das

Ghosh

et al. 2020

Food and Chemical Toxicology

218

121

View full text Add to dashboard Cite

show abstract

“…Increased fasting insulin levels, glucose, and insulin AUCs and IR, all caused by a HFSD, were mitigated by supplementation with raspberry seed flour (RSF) [42]. Raspberry-derived polyphenols were shown to inhibit α-amylase in vitro thus with potential implications for T2DM [43], while the inhibitory effect of raspberry ketone on α-glucosidase was demonstrated through in silico docking analysis [44]. Thus, various functional components of RR appear to have beneficial effects on glucose handling and insulin sensitivity in several experimental settings.…”

Section: Effects Of Rr Supplementation On Glucose Handling and Insulin Signalingmentioning

confidence: 99%

Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters

Derrick

Kristo

Reaves

et al. 2021

IJERPH

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Type 2 diabetes mellitus (T2DM) is a chronic metabolic condition characterized by glucose clearance abnormalities and insufficient insulin response. Left uncontrolled, T2DM can result in serious complications and death. With no cure available currently and the prevalence of major risk factors such as pre-diabetes and the metabolic syndrome continuously increasing, there is an urgent need for effective treatments with limited or no side effects. Red raspberries (RR) contain various phytonutrients with potential for modulating insulin function, glucose, and lipid metabolism. The objective of this literature review was to investigate the potential metabolic benefits of dietary RR in individuals with T2DM and pre-diabetes. A search of major scientific databases was employed to identify peer-reviewed, in vivo, or human studies that utilized whole RR or its functional constituents as treatment. The studies examined provide evidence that RR may offer clinically beneficial effects for the prevention and management of chronic diseases through improvements in glucose handling and insulin sensitivity, adiposity, lipid profiles, ectopic lipid accumulation, inflammation, oxidative stress, and cardiac health. More human trials and in vivo studies are needed to confirm the benefits of dietary RR in T2DM and pre-diabetes and to explore the dose-dependent relationships, optimal duration, and treatment modality.

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“…This dosage is far higher than the usual dietary intake from fruits and flavorings (1.8- Considering the limited studies available, raspberry ketone cannot be recommended at this time for weight loss 3.8 mg/day). Due to the lack of clinical evidence, there is a need for further investigations to evaluate safety and side effects of such supplementation [123]. The raspberry ketone has the potential adverse effect of cardiotoxicity, as well as a teratogenic effect [123].…”

Section: Safety and Drug Interactionsmentioning

confidence: 99%

“…Due to the lack of clinical evidence, there is a need for further investigations to evaluate safety and side effects of such supplementation [123]. The raspberry ketone has the potential adverse effect of cardiotoxicity, as well as a teratogenic effect [123]. Raspberry ketone may interact with anti-diabetic drugs as well as with some blood clotting medications including warfarin [124].…”

Section: Safety and Drug Interactionsmentioning

confidence: 99%

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

Barrea¹,

Altieri²,

Polese³

et al. 2019

Int J Obes Supp

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Over the past 20 years the use of dietary supplements as adjuvant therapy for weight loss gained growing favor among consumers and dietician-nutritionists, with the subsequent astounding increase in health costs. Despite the reassuring label of natural remedy for losing weight, dietary supplements contain a wide variety of ingredients on which available information is rather scanty and scientifically incomplete. Currently, there is little evidence that weight-loss supplements offer effective aids to reduce weight and meet criteria for recommended use. Robust, randomized, placebo-controlled studies to provide clear-cut scientific evidence of their efficacy and potential side effects in clinical practice are still lacking. Understanding the evidence for the efficacy, safety, and quality of these supplements among nutritionists and physicians is critical to counsel patients appropriately, especially considering the risk of serious adverse effects and interference with concomitant therapies. Detailed information on the efficacy and safety of the most commonly used weight-loss dietary supplements has been recently published by the National Institutes of Health (NIH). However, in this report the thorny issue that may result from drug interactions with weight-loss dietary supplements has been not sufficiently addressed. The aim of this review was to provide a synthetic, evidence-based report on efficacy and safety of the most commonly used ingredients in dietary supplements marketed for weight loss, particularly focusing on their possible drug interactions.

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Inhibitory effect of raspberry ketone on α-glucosidase: Docking simulation integrating inhibition kinetics

Cited by 32 publications

References 38 publications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

An overview on the role of bioactive α-glucosidase inhibitors in ameliorating diabetic complications

Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters

Nutritionist and obesity: brief overview on efficacy, safety, and drug interactions of the main weight-loss dietary supplements

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