Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters

Derrick, Stefani A.; Kristo, Aleksandra S.; Reaves, Scott K.; Sikalidis, Angelos K.

doi:10.3390/ijerph18179364

Cited by 22 publications

(17 citation statements)

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“…Nevertheless, the bioavailability of natural β-carotene in plants is low [ 12 ]. Some factors impacting bioavailability include change of cell wall structure when processing foods and interaction with other dietary ingredients and phytochemicals in the gastrointestinal tract [ 13 , 14 ]. Hence, more attention has been given to β-carotene supplementation, which has become an alternative for people to meet the recommended intake of β-carotene.…”

Section: Introductionmentioning

confidence: 99%

β-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang

Zhang

et al. 2022

Nutrients

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β-carotene is widely available in plant-based foods, while the efficacy of β-carotene supplementation on cardiovascular disease (CVD) risk remains controversial. Hence, we performed a systematic review and meta-analysis on randomized controlled trials to investigate the associations between β-carotene supplementation and CVD risk as well as mortality. We conducted literature searches across eight databases and screened the publications from January 1900 to March 2022 on the topic of β-carotene treatments and cardiovascular outcomes. There were 10 trials and 16 reports included in the meta-analysis with a total of 182,788 individuals enrolled in the study. Results from the random-effects models indicated that β-carotene supplementation slightly increased overall cardiovascular incidence (RR: 1.04; 95% CI: 1.00, 1.08) and was constantly associated with increased cardiovascular mortality (RR: 1.12; 95% CI: 1.04, 1.19). Subgroup analyses suggested that, when β-carotene treatments were given singly, a higher risk of cardiovascular outcomes was observed (RR: 1.06; 95% CI: 1.01, 1.12). In addition, cigarettes smoking was shown to be a risk behavior associated with increased cardiovascular incidence and mortality in the β-carotene intervention group. In sum, the evidence of this study demonstrated that β-carotene supplementation had no beneficial effects on CVD incidence and potential harmful effects on CVD mortality. Further studies on understanding the efficacy of multivitamin supplementation in nutrient-deficient or sub-optimal populations are important for developing the tolerable upper intake level for β-carotene of different age and sex groups.

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Section: Introductionmentioning

confidence: 99%

β-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Yang

Zhang

et al. 2022

Nutrients

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“…Of all the metabolites analyzed in this study, those belonging to the carotenoid family had the most significant influence on metabolic parameters. A regular intake of raspberries has been reported to have positive effects on many metabolic parameters, including improved glucose, insulin, and lipid metabolism as well as reduced inflammation and oxidation ( 9 , 32 , 33 ). These berries contain many carotenoids ( 34 ), which have been linked to positive effects on metabolic health.…”

Section: Discussionmentioning

confidence: 99%

A discriminant analysis of plasma metabolomics for the assessment of metabolic responsiveness to red raspberry consumption

et al. 2023

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BackgroundMany studies show that the intake of raspberries is beneficial to immune-metabolic health, but the responses of individuals are heterogeneous and not fully understood.MethodsIn a two-arm parallel-group, randomized, controlled trial, immune-metabolic outcomes and plasma metabolite levels were analyzed before and after an 8-week red raspberry consumption. Based on partial least squares discriminant analysis (PLS-DA) on plasma xenobiotic levels, adherence to the intervention was first evaluated. A second PLS-DA followed by hierarchical clustering was used to classify individuals into response subgroups. Clinical immune and metabolic outcomes, including insulin resistance (HOMA-IR) and sensitivity (Matsuda, QUICKI) indices, during the intervention were assessed and compared between response subgroups.ResultsTwo subgroups of participants, type 1 responders (n = 17) and type 2 responders (n = 5), were identified based on plasma metabolite levels measured during the intervention. Type 1 responders showed neutral to negative effects on immune-metabolic clinical parameters after raspberry consumption, and type 2 responders showed positive effects on the same parameters. Changes in waist circumference, waist-to-hip ratio, fasting plasma apolipoprotein B, C-reactive protein and insulin levels as well as Matsuda, HOMA-IR and QUICKI were significantly different between the two response subgroups. A deleterious effect of two carotenoid metabolites was also observed in type 1 responders but these variables were significantly associated with beneficial changes in the QUICKI index and in fasting insulin levels in type 2 responders. Increased 3-ureidopropionate levels were associated with a decrease in the Matsuda index in type 2 responders, suggesting that this metabolite is associated with a decrease in insulin sensitivity for those subjects, whereas the opposite was observed for type 1 responders.ConclusionThe beneficial effects associated with red raspberry consumption are subject to inter-individual variability. Metabolomics-based clustering appears to be an effective way to assess adherence to a nutritional intervention and to classify individuals according to their immune-metabolic responsiveness to the intervention. This approach may be replicated in future studies to provide a better understanding of how interindividual variability impacts the effects of nutritional interventions on immune-metabolic health.

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“…The bioactive compounds of berries in particular include powerful antioxidant anthocyanins (such as cyanidin and delphinidin), flavanols and phenolic acids (such as ellagitannins/ellagic acid), which can inhibit the enzymes amylase and glucosidase, preventing glucose absorption in the intestines (controlling postprandial glycaemia) and stimulating insulin secretion [ 14 , 15 ]. Berry anthocyanins enhance glucose uptake and metabolism through pAMPK/AMPK, GLUT-4 and SGLUT-1 activation; they also inhibit weight gain and pro-inflammatory responses, downregulating lipogenesis genes and pro-inflammatory cytokine production [ 16 ].…”

Section: Discussionmentioning

confidence: 99%

Superfoods for Type 2 Diabetes: A Narrative Review and Proposal for New International Recommendations

Pires

2023

Medicina

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Background and Objectives: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease affecting an estimated 537 million individuals worldwide. ‘Superfoods’ can be integrated into the diet of T2DM patients due to their health benefits. Study Objectives: (i) To carry out a narrative review of ‘superfoods’ with the potential to reduce glycaemic levels in T2DM patients (2019 to 2022), (ii) to identify ‘superfoods’ with the potential to reduce HbA1c and (iii) to propose new guidance on the use of ‘superfoods’. Materials and Methods: A narrative review was carried out using the databases PubMed, SciELO, DOAJ and Google Scholar. The keywords were [“type 2 diabetes” and (“food” or “diet” or “nutrition”) and (“glycaemia” or “glycemia”)]. Only review studies were included. Results: Thirty reviews were selected. The ‘superfoods’ identified as having a potential impact on glycaemic control were foods with polyphenols (e.g., berries), fermented dairy products, whole cereals/grains, nuts and proteins, among others. The possibility of an extensive reduction in Hb1Ac was reported for fermented dairy products, especially yoghurts enriched with vitamin D or probiotics (HbA1c reduction of around 1%) or by increasing the fibre intake by 15 g (or up to 35 g) (HbA1c reduction of around 2%). Conclusion: It is recommended that the identified ‘superfoods’ are included in the diet of T2DM patients, although this should not substitute an appropriate diet and exercise plan. In particular, yoghurts and an increased fibre intake (by 15 g or up to 35 g) can be used as nutraceuticals. New recommendations on the introduction of ‘superfoods’ in the diet of T2DM patients have been proposed.

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Effects of Dietary Red Raspberry Consumption on Pre-Diabetes and Type 2 Diabetes Mellitus Parameters

Cited by 22 publications

References 50 publications

β-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

β-Carotene Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

A discriminant analysis of plasma metabolomics for the assessment of metabolic responsiveness to red raspberry consumption

Superfoods for Type 2 Diabetes: A Narrative Review and Proposal for New International Recommendations

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